Human Genetics
Decreased levels of soluble receptor for advanced glycation end-products in aortic valve calcification patients
Authors: H. Zheng,Y. Li,N. Xie,J.L. Huang,H.F. Xu and M. Luo
The soluble receptor for advanced glycation end-products (sRAGE) shows a close relationship with atherosclerosis. The goal of this study was to compare the levels of sRAGE in patients with and without aortic valve calcification and to investigate the relationship between them. After transthoracic echocardiographic examination, 120 male patients with aorti.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.22.6
- DOI:
- http://dx.doi.org/10.4238/2015.April.22.6
Diallelic analysis to obtain cowpea (Vigna unguiculata L. Walp.) populations tolerant to water deficit
Authors: E.V. Rodrigues, K.J. Damasceno-Silva, M.M. Rocha and E.A. Bastos
The purpose of this study was to identify parents and obtain segregating populations of cowpea (Vigna unguiculata L. Walp.) with the potential for tolerance to water deficit. A full diallel was performed with six cowpea genotypes, and two experiments were conducted in Teresina, PI, Brazil in 2011 to evaluate 30 F2 populations .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027996
- DOI:
- 10.4238/gmr.15027996
Analysis of tacrolimus blood concentrations in renal transplant patients
Authors: C.Y. Wang,X. Xu,M.C. Li,Q. Li and S.G. Ji
This study aimed to 1) analyze the results of tacrolimus blood concentration monitored in patients after renal transplantation, 2) observe and establish an optimal therapeutic window for patients, and 3) provide evidence for the clinical and rational use of drugs. Tacrolimus blood concentration was determined by enzyme-linked immunosorbent assay. A total .. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.22.8
- DOI:
- http://dx.doi.org/10.4238/2015.April.22.8
Association of NT-proBNP and interleukin-17 levels with heart failure in elderly patients
Authors: X.F. Li, D. Pan, W.L. Zhang, J. Zhou and J.J. Liang
Pro-B-type natriuretic peptide (NT-proBNP) and interleukin-17 (IL-17) are involved in the pathophysiological processes of heart failure; however, the exact role of IL-17 is not clear. We explored the relationship between IL-17 and NT-proBNP, as a clinical parameter, in heart failure. The whole blood IL-17 and NT-proBNP levels .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028014
- DOI:
- 10.4238/gmr.15028014
Screening for fragile X syndrome in males from specialized institutions in the northeast region of Brazil
Authors: M.T.M. Viveiros, M.D.C. Santos, J.M. Dos Santos, D.M. Viveiros, M.R.M. Cavalcante, A.J.M. Caldas and M.M.G. Pimentel
The objective of this study was to perform a study of fragile X syndrome (FXS) in São Luís, Maranhão, in males residing in five specialized institutions. Two hundred thirty-eight males with intellectual disability of unknown etiology participated in this study. Blood samples were processed and stored until DNA extraction. Screening fo.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.18.32
- DOI:
- 10.4238/2015.June.18.32
Molecular characterization of a Han Chinese family with essential hypertension
Authors: J.F. Zhu, X. Zhang and L. Ling
Mutations in the mitochondrial genome have been found to be associated with essential hypertension. Here, we report the clinical and molecular characterization of a three-generation Han Chinese family with maternally inherited hypertension. Most strikingly, this pedigree exhibited a high penetrance of hypertension. Sequence an.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028084
- DOI:
- 10.4238/gmr.15028084
Antimicrobial and antitumor activity and diversity of endophytic fungi from traditional Chinese medicinal plant Cephalotaxus hainanensis Li
Authors: Y.-H. Liu, X.-P. Hu, W. Li, X.-Y. Cao, H.-R. Yang, S.-T. Lin, C.-B. Xu, S.-X. Liu and C.-F. Li
Endophytes from Cephalotaxus hainanensis Li, an important source of anti-leukemia drugs, have not been widely explored. In this study, 265 endophytic fungal isolates from C. hainanensis Li were screened for antimicrobial activities against tilapia, banana, rice, and rape and for antitumor activities against human leukemia cell.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028633
- DOI:
- 10.4238/gmr.15028633
Detection of Piwi-interacting RNAs based on sequence features
Authors: Y.J. Liu, J.Y. Zhang, A.M. Li, Z.W. Liu, Y.Y. Zhang and X.H. Sun
Piwi-interacting RNAs (piRNAs) are a class of small non-coding RNAs. Distinguishing piRNAs from other non-coding RNAs is important because of their important role in the physiological regulation of spermatogenesis, genome protection from transposons, and regulation of mRNAs and long non-coding RNAs. Few computational studies h.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028638
- DOI:
- 10.4238/gmr.15028638
Genetic polymorphisms and haplotype of hormone-related genes are associated with the risk of breast cancer in Chinese women
Authors: Z. Pan, Z. Fu, Q. Song, W. Cao, W. Cheng and X. Xu
Sex hormones play important roles in breast cancer (BC) development. This study investigated associations between BC risk and hormone-related gene variants in Chinese women. In a cohort of 336 patients with histopathologically confirmed BC and 390 age-matched controls, we genotyped seven single nucleotide polymorphisms (SNPs) .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028640
- DOI:
- 10.4238/gmr.15028640
Decreased microRNA-143 expression and its tumor suppressive function in human oral squamous cell carcinoma
Authors: Z.Y. Ni, F.O. Lin, D.F. Liu and J. Xiao
MicroRNA-143 serves as a tumor suppressor in many human malignancies. However, its involvement in oral squamous cell carcinoma (OSCC) is still unclear. In this study, we investigated the effects of miR-143 in OSCC tumorigenesis and development. Using real-time quantitative reverse transcription-polymerase chain reaction, we detected miR-143 expression in .. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.26.2
- DOI:
- 10.4238/2015.June.26.2