Human Genetics
Association between matrix metalloproteinase-9 rs3918242 polymorphism and development of coronary artery disease in a Chinese population
Authors: L.M. Qin, G.M. Qin, X.H. Shi, A.L. Wang and H. Zuo
We conducted a case-control study to investigate the role of one single nucleotide polymorphism of MMP-9 rs3918242 in the development of coronary artery disease. The rs3918242 was amplified with 435-bp DNA fragments using polymerase chain reaction coupled with restriction fragment length polymorphism. When compared with contro.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027632
- DOI:
- 10.4238/gmr.15027632
A single nucleotide polymorphism in the promoter region (rs10877887) of let-7 is associated with hepatocellular carcinoma in a Chinese population
Authors: Z.Y. Sui, J. Li, G.L. Cheng and S.F. Wang
Hepatocellular carcinoma (HCC) is a complex polygenic disease whose development is dependent on many genetic factors. The let-7 family, an important and widely studied microRNA family, has been shown to play an important role in the initiation and progression of HCC. In this study, we examined the possible associations between.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027661
- DOI:
- 10.4238/gmr.15027661
Identification of altered pathways in hypertrophic cardiomyopathy based on combined data of protein-protein interactions and molecular pathways
Authors: S.W. Zhang, J. Wang and J. Pan
The purpose of our study was to identify molecular pathways altered during the pathogenesis of hypertrophic cardiomyopathy (HCM) based on data from the STRING protein-protein interaction (PPI) database and the REACTOME pathway database. Identification of differentially expressed genes (DEGs) was carried out, followed by constr.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027754
- DOI:
- 10.4238/gmr.15027754
Investigating the role of polymorphisms in miR-146a, -149, and -196a2 in the development of gastric cancer
Authors: J.Y. Gu and L. Tu
Here, we performed a case-control study to investigate the role of miR-146a, miR-149, and miR-196a2 polymorphisms in the development of gastric cancer using a hospital-based case-control design. A total of 186 gastric cancer patients and 186 control subjects were enrolled from Ren Ji Hospital between January 2012 and October 2.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027839
- DOI:
- 10.4238/gmr.15027839
Adeno-associated virus-mediated BMP-7 and SOX9 in vitro co-transfection of human degenerative intervertebral disc cells
Authors: X.F. Ren, Z.Z. Diao,Y.M. Xi,Z.H. Qi,S. Ren,Y.J. Liu,D.L. Yang,X. Zhang and S.L. Yuan
Bone morphogenetic protein-7 (BMP-7) and SOX9 are important transcription factors in chondrogenesis. In this study, we examined the biological function of the adeno-associated virus (AAV)-mediated BMP-7 and SOX9 double gene in vitro co-transfection of nucleus pulposus cells of human degenerative intervertebral disc. Human intervertebral disc nucleus pulpo.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.22.1
- DOI:
- http://dx.doi.org/10.4238/2015.April.22.1
Role and diagnostic value of gene variants in assessing the risk of chronic obstructive pulmonary disease
Authors: Z.P. Yan, X. Tong, S.T. Liu, Y. Ma, S.F. Peng, X. Yang and H. Fan
Meta-analyses have revealed many positive associations between gene variants and susceptibility to chronic obstructive pulmonary disease (COPD). However, some of those positive results may be false positives. Therefore, we investigated the genetic polymorphisms associated with COPD risk and determined their diagnostic value. W.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027854
- DOI:
- 10.4238/gmr.15027854
Effects of siRNA-mediated silencing of Sal-like 4 expression on proliferation and apoptosis of prostate cancer C4-2 cells
Authors: K.F. Liu and Y.X. Shan
The aim of this study was to evaluate the effects of small interfering RNA (siRNA)-inhibited expression of the Sal-like 4 (SALL4) gene on the proliferation, colony formation, and apoptosis of prostate cancer C4-2 cells. C4-2 cells were cultured and divided into a si-SALL4 group, a negative control siRNA group, and a blank cont.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027885
- DOI:
- 10.4238/gmr.15027885
Relationship between genetic polymorphisms in MCP-1, CCR-2, and non-small-cell lung cancer in the Han nationality of Northern China
Authors: L. Yang,J. Wang,F.-G. Li,M. Han,X.-J. Chang and Z.-T. Wang
Lung cancer is a common malignant tumor worldwide and is now the leading cause of cancer-related deaths. Monocyte chemoattractant protein 1 (MCP-1) and its receptor chemokine receptor 2 (CCR-2) are important chemokines. We examined the polymorphisms of 338 unrelated patients with non-small cell lung carcinoma (NSCLC) and 200 unrelated healthy controls of .. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.22.2
- DOI:
- http://dx.doi.org/10.4238/2015.April.22.2
MicroRNA-32 functions as a tumor suppressor and directly targets EZH2 in uveal melanoma
Authors: Y.B. Ma, D.W. Song, R.H. Nie and G.Y. Mu
MicroRNA-32 (miR-32) has been shown to be dysregulated in some human malignancies and this has been found to be correlated with tumor progression. However, its role in uveal melanoma formation and progression remains largely unknown. Thus, the aim of this study was to explore the expression and function of miR-32 in human uvea.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027935
- DOI:
- 10.4238/gmr.15027935
Development and characterization of microsatellite markers for Ulmus chenmoui (Ulmaceae), an endangered tree endemic to eastern China
Authors: Q.F. Geng, J. He, J. Yang, E. Shi, D.B. Wang, W.X. Xu,N. Jeelani Z.S. Wang and H. Liu
Ulmus chenmoui (Ulmaceae) is an endangered tree found on Langya Mountain, eastern China. To better understand the population genetics of U. chenmoui and conserve the species, we developed microsatellite markers. Using a suppression-polymerase chain reaction technique, 74 compound microsatellite primer pairs were designed. Twel.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027985
- DOI:
- 10.4238/gmr.15027985