Human Genetics
Significantly association of diabetes mellitus with CTLA-4 gene polymorphisms based on a meta-analysis of epidemiological evidence in Asians and non-Asians
Authors: J. Liu, H.X. Zhang, G.Y. Feng and L. He
We evaluated association of polymorphisms in the CTLA-4 gene with the risk of type 1 diabetes mellitus. Comprehensive meta-analysis was applied to case-control studies of the association between CTLA-4 and type 1 diabetes mellitus to assess the joint evidence for the association, the influence of individual studies, and evidence for publication bias. We s.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.23.11
- DOI:
- 10.4238/2013.September.23.11
Correlation between the 677C>T polymorphism in the methylene tetrahydrofolate reductase gene and serum homocysteine levels in coronary heart disease
Authors: Y.Y. Chen, B.N. Wang and X.P. Yu
The aim of the current study was to explore the correlation between serum homocysteine (HCY) levels and the methylene tetrahydrofolate reductase (MTHFR) gene 677C/T polymorphism and coronary heart disease (CHD). We consecutively enrolled 208 patients with CHD confirmed by CTA or coronary angiography from our hospital. An addit.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017238
- DOI:
- 10.4238/gmr.15017238
Prediction of health risk due to polycyclic aromatic hydrocarbons present in urban air in Rio de Janeiro, Brazil
Authors: C.R. Rainho, A.M.A. Velho, S.M. Corr�ªa, J.L. Mazzei, C.A.F. Aiub and I. Felzenszwalb
Risk assessment can provide a comprehensive estimate of potential effects of contaminants under specific, well-defined, and well-described circumstances, providing quantitative relationships between exposure and effects to identify and to define areas of concern. We investigated the mutagenic activity of particulate matter in air samples collected from th.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.February.28.6
- DOI:
- 10.4238/2013.February.28.6
Karyotype structure of Hypostomus cf. plecostomus (Linnaeus, 1758) from Tapaj�³s River basin, Southern Amazon: occurrence of sex chromosomes (ZZ/ZW) and their evolutionary implications
Authors: L.C. Oliveira, M.O. Ribeiro, E.S. Dutra, C.H. Zawadzki, A.L.B. Portela-Castro5 and I.C. Martins-Santos
Hypostomus is a group of fish with numerical and structural karyotypic variability. Among them, only six species, three of which belong to the Amazon basin, show a sex chromosome. In this study, we present the karyotype structure of Hypostomus cf. plecostomus from the Teles Pires river basin in the municipality of Alta Floresta, MT. The species has 2n = 6.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.18.5
- DOI:
- 10.4238/2015.June.18.5
Identification of a locus characteristic of male individuals of buffalo grass [Buchloe dactyloides (Nutt.) Engelm.] by using an RAPD marker
Authors: Y.X. Li, X.G. Wang, C.H. Yang, L.L. Cong, F.F. Wu, J.G. Xue and Y.H. Han
Buffalo grass [Buchloe dactyuloides (Nutt.) Engelm.] plants can be either male, female, or hermaphrodite (monoecious). As there is no morphological difference in the early vegetative growth of these three classes of plants, it is worthwhile to use molecular biological methods to attempt to identify the sex of a plant at this early growth period. In this s.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.27.8
- DOI:
- 10.4238/2013.September.27.8
Relationship between zinc finger protein 36 (ZFP36) gene polymorphisms and obstructive sleep apnea
Authors: Y. Zhang, N.-F. Li, S. Abulikemu, D.-L. Zhang, Y.-C. Wang, J.-Q. Kong, G.-L. Nuer, Z.-T. Yan, H.-J. Li, J.-H. Zhang and X.-Y. Zhang
Recent data have indicated that inflammation may have an important correlation with obstructive sleep apnea (OSA). Studies have indicated a relationship between OSA and TNF-α gene polymorphisms. Zinc finger protein 36 (ZFP36) regulates TNF-α mRNAs. However, ZFP36 gene polymorphisms have not been investigated in OSA. Therefore, we conducted the.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.18.17
- DOI:
- 10.4238/2015.June.18.17
Evaluation of the efficiency of artificial neural networks for genetic value prediction
Authors: G.N. Silva, R.S. Tomaz, I.C. Sant�Anna, V.Q. Carneiro, C.D. Cruz and M. Nascimento
Artificial neural networks have shown great potential when applied to breeding programs. In this study, we propose the use of artificial neural networks as a viable alternative to conventional prediction methods. We conduct a thorough evaluation of the efficiency of these networks with respect to the prediction of breeding values. Therefore, we considered.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017676
- DOI:
- 10.4238/gmr.15017676
Artificial neural networks reveal efficiency in genetic value prediction
Authors: L.A. Peixoto, L.L. Bhering and C.D. Cruz
The objective of this study was to evaluate the efficiency of artificial neural networks (ANNs) for predicting genetic value in experiments carried out in randomized blocks. Sixteen scenarios were simulated with different values of heritability (10, 20, 30, and 40%), coefficient of variation (5 and 10%), and the number of genotypes per block (150 and 200 .. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.18.22
- DOI:
- 10.4238/2015.June.18.22
Novel splice variants of the bovine PCK1 gene
Authors: Z.B. Zhang, W. Zhang, R.L. Li, J.B. Li, J.F. Zhong, Z.S. Zhao and J.M. Huang
Phosphoenolpyruvate carboxykinase 1 (PCK1), also named PEPCK-C, is a multiple-function gene that is involved in gluconeogenesis, glyceroneogenesis, reproduction, female fertility, and development of obesity and diabetes. How its many functions are regulated was largely unknown. Therefore, we investigated mRNA expression and possible splice variants of PCK.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.27.4
- DOI:
- 10.4238/2013.September.27.4
STAT1 inhibitor alleviates spinal cord injury by decreasing apoptosis
Authors: Y.X. Wu, C.Z. Gao, K.L. Fan, L.M. Yang and X.F. Mei
Spinal cord injury (SCI) is typically caused by trauma or disease, and it severely affects patients’ motor function. The relationship between signal transducers and activators of transcription-1 (STAT1) and neuronal death after cerebral focal ischemia has been comprehensively studied, but its role in SCI remains largely .. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017271
- DOI:
- 10.4238/gmr.15017271