Human Genetics
Genomic DNA isolation of Acrocomia aculeata (Arecaceae) from leaf and stipe tissue samples for PCR analysis
Authors: E.C.M. Lanes, C. Nick, K.N. Kuki, R.D. Freitas and S.Y. Motoike
Macaw palm, Acrocomia aculeata is an oleaginous species of the Arecaceae family; it has been identified as one of the most promising plants for sustainable production of renewable energy, especially biodiesel. We developed an efficient protocol of genomic DNA extraction for A. aculeata using leaf and stipe tissues, based on the cationic hexadecyltrimethyl.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.23.9
- DOI:
- 10.4238/2013.September.23.9
Altered expression of CG5961, a putative Drosophila melanogaster homologue of FBXO9, provides a new model of Parkinson disease
Authors: E.M. Merzetti and B.E. Staveley
F-box proteins act as the protein recognition component of the Skp-Cul-F-box class of ubiquitin ligases. Two members of a gene sub-family encoding these proteins, FBXO7 and FBXO32, have been implicated in the onset and progression of degenerative disease. FBXO7 is responsible for rare genetic forms of Parkinson disease, while .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028579
- DOI:
- 10.4238/gmr.15028579
Bean (Phaseolus vulgaris L.) lines: chemical composition and protein digestibility
Authors: F.R. Mesquita, M.I.A. Silva and A.D. Corr�?ªa
The bean represents the main source of proteins for the low income populations, although the digestibility of those proteins is relatively low. Consequently, the programs of plant genetic breeding have been working on the search for new lines with higher protein levels. Thus, with the purpose of supplying information to the re.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028587
- DOI:
- 10.4238/gmr.15028587
Time-series microarray data simulation modeled with a case-control label
Authors: Y.J. Liu and J.Y. Zhang
With advances in molecular biology, microarray data have become an important resource in the exploration of complex human diseases. Although gene chip technology continues to grow, there are still many barriers to overcome, such as high costs, small sample sizes, complex procedures, poor repeatability, and the dependence on da.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027287
- DOI:
- 10.4238/gmr.15027287
Expression and clinical significance of Kelch-like epichlorohydrin-associated protein 1 in breast cancer
Authors: L. Zhang, W.P. Yang, L.Y. Wu, X. Zhu and C.Y. Wei
Our objective was to explore the expression and clinical significance of Kelch-like epichlorohydrin-associated protein 1 (Keap1) in breast cancer tissue. Eighty-one breast cancer patients having undergone surgical treatment in our hospital between March 2002 and December 2008 were enrolled in this study. Normal tissue adjacent.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027294
- DOI:
- 10.4238/gmr.15027294
A microRNA-152 that targets the phosphatase and tensin homolog to inhibit low oxygen induced-apoptosis in human brain microvascular endothelial cells
Authors: Y.H. Cao, D.G. Li, B. Xu1 M.Q. Wang, N. Zhen, L.X. Man,Y.Y. Zhang1 and M. Chi
Brain damage caused by perinatal asphyxia is dangerous for neonatal infants, but the mechanism by which it occurs remains elusive. In this study, microRNA-152 (miR-152) expression was induced by low oxygen levels in rat models of hypoxia brain damage, as well as in human brain microvascular endothelial cells (HBMECs) cultured .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027371
- DOI:
- 10.4238/gmr.15027371
Increased expression of the lncRNA BANCR and its prognostic significance in human osteosarcoma
Authors: Z.Q. Peng, R.B. Lu, D.M. Xiao and Z.M. Xiao
Long noncoding RNAs (lncRNAs) play important roles in the formation and progression of many types of human malignancies. The aim of our study was to investigate the expression and biological functions of the lncRNA BRAF-activated noncoding RNA (BANCR) in human osteosarcoma. BANCR expression was quantified by real-time PCR in h.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017480
- DOI:
- 10.4238/gmr.15017480
Relationship between the polymorphisms in KCNQ1 and type 2 diabetes in Chinese Kazakh population
Authors: L.J. Cui, X.Y. Chang, L.Y. Zhu, G. Feng, T. Zhou, C.X. Zhang, K.Y. Chong and K. Sun
Recently genome-wide association studies on East Asian populations reported an association between diabetes and several single nucleotide polymorphisms (SNPs) in a 40-kb linkage disequilibrium block in intron 15 of KCNQ1. However, the association between KCNQ1 variants and type 2 diabetes mellitus (T2DM) in Chinese Kazakh popu.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027503
- DOI:
- 10.4238/gmr.15027503
Effect of ozone on vascular endothelial growth factor (VEGF) and related inflammatory cytokines in rats with diabetic retinopathy
Authors: T.Y. Xie, W. Yan, J. Lou and X.Y. Chen
The aim of this study was to investigate the effect of ozone on inflammatory cytokines in diabetic retinopathy (DR) rats. Male rats (40) weighing 300-360 g were included in this study. Thirty rats were randomly divided into the model and ozone groups after DR was induced by streptozotocin. Ten rats served as the blank group. A.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027558
- DOI:
- 10.4238/gmr.15027558
Protective effect of the polarity of macrophages regulated by IL-37 on atherosclerosis
Authors: J. Huang, F.L. Hou, A.Y. Zhang and Z.L. Li
As an anti-inflammatory cytokine, interleukin-37 (IL-37) provides certain protective effects against inflammatory and autoimmune diseases. Recent reports indicate that IL-37 is expressed in foam cells of atherosclerotic plaques in both the coronary and carotid arteries of humans, suggesting the possible involvement of IL-37 in.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027616
- DOI:
- 10.4238/gmr.15027616