Human Genetics
Role of IL-10 gene polymorphisms in the development of acute pancreatitis
Authors: B.Z. Jiang, L. Tang, H. Xue and D.P. Liu
Recent studies have suggested that chemokines contribute to the initiation and development of acute pancreatitis. We evaluated the relationship between IL-10 gene polymorphisms (-1082A/G and -819T/C) and development of acute pancreatitis in the Chinese population, in order to provide data for screening high-risk Chinese indivi.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027743
- DOI:
- 10.4238/gmr.15027743
Molecular docking of the anticancer bioactive compound proceraside with macromolecules involved in the cell cycle and DNA replication
Authors: A.B. Gurung, M.A. Ali, A. Bhattacharjee, M. AbulFarah, F. Al-Hemaid, F.M. Abou-Tarboush, K.M. Al-Anazi, F.S.M. Al-Anazi and J. Lee
The bioactive compounds proceraside A, frugoside and calotropin, which were extracted from the root bark of Calotropis procera (Aiton) W.T. Aiton (family Asclepiadaceae), were recently reported to inhibit the growth of inhibition against various human cancer cell lines in vitro. However, their modes of action have not been cle.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027829
- DOI:
- 10.4238/gmr.15027829
Drosha, DGCR8, and Dicer mRNAs are down-regulated in human cells infected with dengue virus 4, and play a role in viral pathogenesis
Authors: S.M.M. Casseb, D.B. Simith, K.F.L. Melo, M.H. Mendon�§a, A.C.M. Santos, V.L. Carvalho, A.C.R. Cruz and P.F.C. Vasconcelos
Dengue virus (DENV) and its four serotypes (DENV1-4) belong to the Flavivirus genus of the Flaviviridae family. DENV infection is a life-threatening disease, which results in up to 20,000 deaths each year. Viruses have been shown to encode trans-regulatory small RNAs, or microRNAs (miRNAs), which bind to messenger RNA and nega.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027891
- DOI:
- 10.4238/gmr.15027891
Expression profile of rice Hsp genes under anoxic stress
Authors: L.M. Mertz-Henning, C. Pegoraro, L.C. Maia, E. Venske, C.V. Rombaldi and A. Costa de Oliveira
Although flooding is one of the most important environmental stresses worldwide, not all plant species are intolerant to its effects. Species from semi-aquatic environments, such as rice, have the capacity to cope with flooding stress. Heat-shock proteins (Hsps) are thought to contribute to cellular homeostasis under both opti.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027954
- DOI:
- 10.4238/gmr.15027954
Role of PPAR�± in down-regulating AGE-induced TGF-�² and MMP-9 expressions in chondrocytes
Authors: J. Wang, G. Wang and G.W. Sun
Peroxisome proliferator-activated receptor is closely associated with the pathogenesis of osteoarthritis. The level of exogenous advanced glycation end-products (AGEs) in articular cartilage is highly associated with the severity of osteoarthritic lesions. However, their interactions and role in promoting osteoarthritisprogres.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027963
- DOI:
- 10.4238/gmr.15027963
Functional polymorphisms of the cyclooxygenase-2 gene and prognosis of hepatocellular carcinoma - a cohort study in Chinese people
Authors: R. Liang, X.X. Yan, Y. Lin, Q. Li, C.L. Yuan, Z.H. Liu and Y.Q. Li
Cyclooxygenase-2 (COX-2) influences carcinogenesis through regulation of angiogenesis, apoptosis, cytokine expression, and immune response suppression. It has been well established that COX-2 is overexpressed in a variety of human cancers, such as hepatocellular carcinoma (HCC). In this study, we aimed to evaluate the associat.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028093
- DOI:
- 10.4238/gmr.15028093
Association between the expression of HIF-1�± and VEGF and prognostic implications in primary liver cancer
Authors: L.Y. Guo, P. Zhu and X.P. Jin
The goal of this study was to investigate the expression of hypoxia-inducible factor-1α (HIF-1α) and vascular endothelial growth factor (VEGF) in primary liver cancer (PLC) and their association with prognosis. Tumor tissue, non-tumor tissue, and blood samples of 75 PLC patients were collected. Blood samples of 20 .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028107
- DOI:
- 10.4238/gmr.15028107
Analysis of FOS, BTG2, and NR4A in the function of renal medullary hypertension
Authors: Y.B. Wu, W.D. Zang, W.Z. Yao, Y. Luo, B. Hu, L. Wang and Y.L. Liang
The aim of this study was to identify differentially expressed genes (DEGs) in renal medullary hypertension and reveal their pathogenic mechanisms. We downloaded the gene expression profile of GSE28360 from the Gene Expression Omnibus database. The profile included 14 samples (5 normal and 9 hypertension). The DEGs in normal and disease samples were disti.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.19.4
- DOI:
- 10.4238/2013.September.19.4
Common variant rs7579169 is associated with preeclampsia in Han Chinese women
Authors: L.F. Guo, Z.H. Wang and Y.F. Wang
As a heterogeneous group of disorders in pregnancy, many genetic factors are involved in the development of preeclampsia. The single nucleotide polymorphism (SNP) rs7579169, located on chromosome 2q14.2, has been shown to be associated with pregnancy-induced hypertension in Europeans. In this study, we examined whether the SNP.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028114
- DOI:
- 10.4238/gmr.15028114
Effect of overexpression of PTEN on apoptosis of liver cancer cells
Authors: M.F. Li, H. Guan and D.D. Zhang
Liver cancer is a common malignant tumor associated with a short-survival period and high-mortality rate, and its prevalence in China is particularly high. This study aimed to investigate the effect of overexpressing the phosphatase and tensin homolog deleted on chromosome 10 (PTEN) gene on liver cancer cell apoptosis and prov.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028120
- DOI:
- 10.4238/gmr.15028120