Human Genetics
Genetic diversity and population structure of Castanopsis eyrei based on simple sequence repeat markers
Authors: L.H. Mao, X.L. Zhou and Y.M. Fang
Castanopsis eyrei (Fagaceae) is one of the dominant tree species in mid-subtropical, evergreen, broad-leaved forests. We obtained 14 pairs of simple sequence repeat (SSR) primers from previous studies, which were used to analyze 90 C. eyrei individuals from three populations at different altitudes. Low heterozygosity was detec.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028256
- DOI:
- 10.4238/gmr.15028256
Clinical features of allergic rhinitis in children of Shanghai, China
Authors: S. He, Y.J. Li and J. Chen
The aims of the current study were to assess the clinical features of allergic rhinitis (AR) in children in Shanghai. Serum-specific IgE (sIgE) tests were performed on samples from patients with AR symptoms from January 2011 to December 2014. A disease-related questionnaire was completed after AR diagnosis. The allergen profil.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028118
- DOI:
- 10.4238/gmr.15028118
A rare case of trisomy 11q23.3-11q25 and trisomy 22q11.1-22q11.21
Authors: P.-S. Zou, H.-F. Li, L.-S. Chen, M. Ma1, X.-H. Chen, D. Xue and D.-H. Cao
Partial duplication of the long arm of chromosome 11 and the partial trisomy of 22q are uncommon karyotypic abnormalities. Here, we report the case of a 6-year-old girl who showed partial trisomy of 11q and 22q, as a result of a maternal balanced reciprocal translocation (11;22), and exhibited dysmorphic features, severe intel.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028140
- DOI:
- 10.4238/gmr.15028140
Nucleotide variation in the Toxoplasma gondii micronemal protein 8 gene
Authors: Z.Y. Li, H.Q. Song, C.R. Wang and X.Q. Zhu
Toxoplasma gondii is a successful opportunistic protozoan distributed worldwide, which can infect all vertebrates, leading to serious infection, blindness, and abortion. Micronemal (MIC) proteins are critically important for T. gondii infection, as they participate in various stages of the Toxoplasma life cycle, including inva.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028578
- DOI:
- 10.4238/gmr.15028578
MicroRNA-154 functions as a tumor suppressor and directly targets HMGA2 in human non-small cell lung cancer
Authors: H.C. Zhuo, Y.F. Song, J. Ye, G.X. Lai and D.L. Liu
MicroRNA-154 (miR-154) is dysregulated in some human malignancies and is correlated with tumor progression. However, its expression and function in non-small cell lung cancer (NSCLC) remain unclear. Therefore, we explored the effects of miR-154 on NSCLC tumorigenesis and development. Using quantitative reverse transcription-po.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028173
- DOI:
- 10.4238/gmr.15028173
Milk fatty acid profile is modulated by DGAT1 and SCD1 genotypes in dairy cattle on pasture and strategic supplementation
Authors: A.M. Carvajal, P. Huircan, J.M. Dezamour, I. Subiabre1, B. Kerr, R. Morales and E.M. Ungerfeld
Milk fat composition is important to consumer health. During the last decade, some fatty acids (FA) have received attention because of their functional and beneficial effects on human health. The milk FA profile is affected by both diet and genetics. Differences in milk fat composition are based on biochemical pathways, and ca.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027057
- DOI:
- 10.4238/gmr.15027057
Biological correlation between glucose transporters, Ki-67 and 2-deoxy-2-[18F]-fluoro-D-glucose uptake in diffuse large B-cell lymphoma and natural killer/T-cell lymphoma
Authors: Y.M. Liu, X.M. Zhai and Y.W. Wu
The purpose of this study was to investigate the association between cellular 2-deoxy-2-[18F]-fluoro-D-glucose (18F-FDG) uptake and the expression of several subtypes of glucose transporters (GLUT) and Ki-67 in diffuse large B-cell lymphoma (DLBCL) and natural killer (NK)/T-cell lymphoma (NKTCL). Cell lines were histologically.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027242
- DOI:
- 10.4238/gmr.15027242
Effect of siRNA-induced silencing of cellular prion protein on tyrosine hydroxylase expression in the substantia nigra of a rat model of Parkinson�s disease
Authors: X. Wang, H.A. Yang, X.N. Wang and Y.F. Du
The most significant pathological feature of Parkinson’s disease (PD) is the progressive degeneration of dopaminergic (DA) neurons in the substantia nigra. Currently, available treatments for PD cannot prevent the loss of DA neurons. Tyrosine hydroxylase (TH) expressed in substantia nigra neurons catalyzes the conversion.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027406
- DOI:
- 10.4238/gmr.15027406
Association between interleukin-10 gene polymorphisms and susceptibility to diabetic nephropathy in a Chinese population
Authors: D.H. Ma, Q.Y. Xu, Y. Liu, Q.Q. Zhai and M.H. Guo
In this study, we investigated the association between the interleukin (IL)-10 -592C/A, -819C/T, and -1082G/A genetic variations and susceptibility to diabetic nephropathy in a Chinese population. The IL-10 -592C/A, -819C/T, and -1082G/A polymorphisms were genotyped in diabetic nephropathy patient and control samples by polyme.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027570
- DOI:
- 10.4238/gmr.15027570
Identification of trends in scientific publications related to genetic polymorphisms in gestational diabetes mellitus
Authors: J.S. Gomes, L.B. Minasi, A.D. da Cruz and F.M. Rodrigues
Gestational diabetes is a genetic multifactorial systemic disease that has been extensively studied. Consequently, there is a large volume of scientific literature pertaining to genes associated with gestational diabetes. The aim of this study was to characterize the main trends in scientific publications focusing on the assoc.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027672
- DOI:
- 10.4238/gmr.15027672