Human Genetics
Evolution of mustard (Brassica juncea Coss) subspecies in China: evidence from the chalcone synthase gene
Authors: F.B. Chen, H.F. Liu, Q.L. Yao and P. Fang
To explore the phylogenetic relationship, genome donor, and evolutionary history of the polyploid mustard (Brassica juncea) from China, eighty-one sequences of the chalcone synthase gene (Chs) were analyzed in 43 individuals, including 34 B. juncea, 2 B. rapa, 1 B. nigra, 2 B. oleracea, 1 B. napus, 1 B. carinata, and 2 Raphanu.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028045
- DOI:
- 10.4238/gmr.15028045
Network spatio-temporal analysis predicts disease stage-related genes and pathways in renal cell carcinoma
Authors: X.H. Li, C.Z. Yang and J. Wang
The purpose of this study was to screen the key genes and pathways of renal cell carcinoma (RCC) and lay the foundation for its diagnosis and therapy. Microarray data of normal subjects and RCC patients at different stages of disease were used to screen differentially expressed genes (DEGs). Based on the DEGs in the four disea.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028061
- DOI:
- 10.4238/gmr.15028061
Expression of transforming growth factor-�²1 in neonatal rats with hyperoxia-induced bronchopulmonary dysplasia and its relationship with lung development
Authors: B. Yan, W. Zhong, Q.M. He, S.Y. Zhang, J.K. Yu and Y.L. Pan
The aim of this study was to detect the expression of transforming growth factor-ß1 (TGF-ß1) in neonatal rats with hyperoxia-induced bronchopulmonary dysplasia (BPD) and to explore its relationship with lung development. Forty-eight rats (2-3 days old) were randomly divided into a hyperoxia group and a control grou.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028064
- DOI:
- 10.4238/gmr.15028064
Comparison of the expression of human equilibrative nucleotide transporter 1 (hENT1) and ribonucleotide reductase subunit M1 (RRM1) genes in seven non-Hodgkin lymphoma cell lines
Authors: H.B. Zhao, X.F. Zhang, F. Shi, M.Z. Zhang and W.L. Xue
We investigated the variability in the expression of human equilibrative nucleoside transporter 1 (hENT1) and ribonucleotide reductase subunit M1 (RRM1) in non-Hodgkin lymphoma cell lines. hENT1 and RRM1 mRNA expression levels in natural killer (NK) cells and seven non-Hodgkin lymphoma cell lines (YTS, SNK-6, Jeko-1, ly-1, Raj.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028275
- DOI:
- 10.4238/gmr.15028275
Apelin polymorphism predicts blood pressure response to losartan in older Chinese women with essential hypertension
Authors: J. Jia, C. Men, K.-T. Tang and Y.-Y. Zhan
We determined whether the blood pressure response to losartan in an older Chinese population with essential hypertension was associated with apelin gene polymorphisms. We genotyped the -1860T>C polymorphism of the apelin gene in a case-control study of 222 patients with hypertension and 250 controls. Following 24 weeks of treatment with losartan (50 mg.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.12.10
- DOI:
- 10.4238/2015.June.12.10
Varicocele and male infertility in Northeast China: Y chromosome microdeletion as an underlying cause
Authors: R.L. Dai,Y. Hou,F.B. Li, J.M. Yue,Q. Xi and R.Z. Liu
The prevalence of Y chromosome microdeletions among azoospermic, severe oligozoospermic, moderate oligozoospermic, and mild oligozoospermic patients with varicocele-related and idiopathic infertility shows conflicting data in Asian countries. We aimed to detect this frequency in Northeast China, and investigated spermatogenic defects whether associated wi.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.12.13
- DOI:
- 10.4238/2015.June.12.13
NDC80 promotes proliferation and metastasis of colon cancer cells
Authors: X.K. Xing, H.Y. Wu, H.L. Chen and H.G. Feng
Chromosome instability is a common feature of tumor cells, and may be an important mechanism in tumor formation. Nuclear division cycle 80 (NDC80) is closely associated with the stability of chromosomes. Therefore, we investigated the relationship between NDC80 and development of colon cancer using a range of methods. Western .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028312
- DOI:
- 10.4238/gmr.15028312
Mapping and validation of Xanthomonas citri subsp citri genes regulated by putative plant-inducible promoter box (PIP-box)
Authors: F.M.S. Carvalho, J.C.F. Oliveira, M.L. Laia, T.R. Jacob,R.M. Ferreira, M.I.T. Ferro, R.I.D. Tezza, S.M. Zingaretti, C.F. Silva and J.A. Ferro
Citrus canker, caused by the Gram-negative bacterium Xanthomonas citri subsp citri (Xac), is a major disease affecting citriculture worldwide, because of the susceptibility of the host and the lack of efficient control methods. Previous studies have reported that some genes of phytopathogenic bacteria possess a consensus nucle.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028428
- DOI:
- 10.4238/gmr.15028428
Ancient DNA in historical parchments - identifying a procedure for extraction and amplification of genetic material
Authors: T. Lech
Historical parchments in the form of documents, manuscripts, books, or letters, make up a large portion of cultural heritage collections. Their priceless historical value is associated with not only their content, but also the information hidden in the DNA deposited on them. Analyses of ancient DNA (aDNA) retrieved from parchm.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028661
- DOI:
- 10.4238/gmr.15028661
Role of MTHFR C677T and MTR A2756G polymorphisms in thyroid and breast cancer development
Authors: T. Zara-Lopes, A.P.A. Gimenez-Martins, C.H.V. Nascimento-Filho, M.M.U. Castanhole-Nunes, A.L.S. Galbiatti-Dias, J.A. Padovani-J�ºnior, J.V. Maniglia, J.L.E. Francisco, E.C. Pavarino and E.M. Goloni-Bertollo
Folate metabolism is essential for DNA synthesis and repair. Alterations in genes that participate in folate metabolism can be associated with several types of malignant neoplasms, including thyroid and breast cancer. In the present case-control study, we examined the association between methylenetetrahydrofolate reductase (MT.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028222
- DOI:
- 10.4238/gmr.15028222