Human Genetics
Cytotoxic and genotoxic potential of geraniol in peripheral blood mononuclear cells and human hepatoma cell line (HepG2)
Authors: T.B. Queiroz, G.F. Santos, S.C. Ventura, C.A. Hiruma-Lima, I.O.M. Gaiv�£o and E.L. Maistro
Geraniol is an acyclic monoterpene alcohol present in the essential oil of many aromatic plants and is one of the most frequently used molecules by the flavor and fragrance industries. The literature also reports its therapeutic potential, highlighting itself especially as a likely molecule for the development of drugs against.. Read More»
- Genet. Mol. Res. 16(3):
- gmr16039777
- DOI:
- 10.4238/gmr16039777
Improving the PCR protocol to amplify a repetitive DNA sequence
Authors: J. Riet, L.R.V. Ramos, R.V. Lewis and L.F. Marins
Although PCR-based techniques have become an essential tool in the field of molecular and genetic research, the amplification of repetitive DNA sequences is limited. This is due to the truncated nature of the amplified sequences, which are also prone to errors during DNA polymerase-based amplification. The complex structure of repetitive DNA can form hair.. Read More»
- Genet. Mol. Res. 16(3):
- gmr16039796
- DOI:
- 10.4238/gmr16039796
Ewes carrying the Booroola and Vacaria prolificacy alleles respond differently to ovulation induction with equine chorionic gonadotrophin
Authors: J.C.F. Moraes and C.J.H. Souza
The magnitude of ovulation rate (OR) after hormonal induction in sheep should be considered when prolific genotypes are used. We investigated for the first time the effect of the Vacaria allele and its combined effect with the Booroola prolificacy mutation on OR after hormonal treatment during breeding and anoestrous season. A.. Read More»
- Genet. Mol. Res. 16(3):
- gmr16039787
- DOI:
- 10.4238/gmr16039787
Association between gastrointestinal cancers and fingerprint patterns in the Iranian population
Authors: S. Abbasi and M. Rasouli
Gastrointestinal cancers are malignant diseases with high mortality rate. Early diagnosis of patients could improve the results of treatment. Many studies used dermatoglyphics as a biomarker to predict the incidence of genetic diseases and cancers. This study assessed the association between gastrointestinal cancers and partic.. Read More»
- Genet. Mol. Res. 16(3):
- gmr16039762
- DOI:
- 10.4238/gmr16039762
Interleukin-18 (rs187238) and glucose transporter 4 (rs5435) polymorphisms in Euro-Brazilians with type 1 diabetes
Authors: Y. Al-Lahham, A.K.B. Mendes, E.M. Souza, D. Alberton, F.G.M. Rego, G. Valdameri and G. Picheth
Type 1 diabetes (T1D) is an autoimmune disease with a strong genetic component that has been associated with several genetic loci. Interleukin 18 (IL-18) is a potent proinflammatory cytokine, which is involved in the innate and adaptive immune responses, and in the pathogenesis of various diseases including T1D. Glucose transp.. Read More»
- Genet. Mol. Res. 16(3):
- gmr16039755
- DOI:
- 10.4238/gmr16039755
Atherosclerosis: analysis of the eNOS (T786C) gene polymorphism
Authors: A.M. Barbosa, K.S.F. Silva, M.H. Lagares, D.A. Rodrigues,I.R. da Costa, M.P. Morais, J.V.M. Martins, R.S. Mascarenhas, F.L. Campedelli and K.K.V.O. Moura
The coronary arteriosclerotic disease is the most common cardiovascular disease. Atherosclerosis affects large- and medium-sized arteries leading to severe thrombosis or artery stenosis that could evolve to myocardial infarction, ischemic stroke, ischemic injury of kidneys and intestines, and several other life-threatening cli.. Read More»
- Genet. Mol. Res. 16(3):
- gmr16039708
- DOI:
- 10.4238/gmr16039708
Clinical features of Mexican patients with Mucopolysaccharidosis type I
Authors: A. Alonzo-Rojo, J.E. GarcÃ?Âa-Ortiz, M. Ortiz-Aranda, M.P. Gallegos-Arreola and L.E. Figuera-Villanueva
Mucopolysaccharidosis type I (MPS-I) is an autosomal recessive lysosomal storage disorder caused by a deficiency or absence of α-l-iduronidase, which is involved in the catabolism of glycosaminoglycans (GAGs). This deficiency leads to the accumulation of GAGs in several organs. Given the wide spectrum of the disease, MPS.. Read More»
- Genet. Mol. Res. 16(3):
- gmr16032602
- DOI:
- 10.4238/gmr16032602
Role of IL17A rs2275913 and rs3748067 polymorphisms in the risk cervical cancer
Authors: A.Q. Niu, Y.H. Cao, H. Wang, X. Zhang, B. Zhu and Z.H. Li
Cervical cancer is a serious public health problem and is associated with high cancer-related mortality in females worldwide. The expression of IL17A can increase the migration and invasiveness of cervical cancer cells by activating the NF-κB signal pathway. Single-nucleotide polymorphisms (SNPs) can alter gene function .. Read More»
- Genet. Mol. Res. 16(3):
- gmr16038826
- DOI:
- 10.4238/gmr16038826
Mac-1 deficiency induces respiratory failure by affecting type I alveolar epithelial cells
Authors: J. Wang, Y.B. Ci, C.L. Liu and H.M. Sun
As a β2 integrin family member, Mac-1 plays an important role in the inflammatory response. Inflammation and lung injury are closely associated, but the involvement of Mac-1 in the occurrence and development of such pathologies remains poorly understood. We aimed to investigate the relationship between Mac-1 deficiency an.. Read More»
- Genet. Mol. Res. 16(3):
- gmr16039045
- DOI:
- 10.4238/gmr16039045
Suppression of the biological activity of neuroglioma cells by down-regulation of miR-1
Authors: Y.Q. Wang, Y. Cai and X.M. Zhong
Neuroglioma is associated with high rates of malignancy, metastasis, and recurrence. Recently, research on the roles of microRNAs (miR) in cancer prognosis has formed an important area of research as differential expression of miRNAs has been observed in different cancers. However, the detailed mechanism by which miRNAs regula.. Read More»
- Genet. Mol. Res. 16(3):
- gmr16039256
- DOI:
- 10.4238/gmr16039256