Bioinformatics
Co-evolution of genomic islands and their bacterial hosts revealed through phylogenetic analyses of 17 groups of homologous genomic islands
Authors: F.-B. Guo W. Wei X.L. Wang H. Lin H. Ding J. Huang N. Rao
Horizontal gene transfer is an important mechanism for the evolution of microbial genomes, and many horizontal gene transfer events are facilitated by genomic islands (GIs). Until now, few reports have provided evidence for the co-evolution of horizontally transferred genes and their hosts. We obtained 17 groups of homologous GIs, all of which appear in 8.. Read More»
- Genet. Mol. Res. 11(4):
- 2012.October.15.5
- DOI:
- 10.4238/2012.October.15.5
E2F, HSF2, and miR-26 in thyroid carcinoma: bioinformatic analysis of RNA-sequencing data
Authors: J.C. Lu and Y.P. Zhang
In this study, we examined the molecular mechanism of thyroid carcinoma (THCA) using bioinformatics. RNA-sequencing data of THCA (N = 498) and normal thyroid tissue (N = 59) were downloaded from The Cancer Genome Atlas. Next, gene expression levels were calculated using the TCC package and differentially expressed genes (DEGs) were identified using the ed.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017576
- DOI:
- 10.4238/gmr.15017576
Selection of putative Terra Maranh�£o plantain cultivar mutants obtained by gamma radiation
Authors: R.V. Reis, E.P. Amorim, C.A.S. Ledo, R.K.N. Pestana, Z.S. Gon�§alvesand A. Bor�©m
The aim of this study was to select putative Terra Maranhão plantain cultivar mutants obtained by gamma radiation, with good agronomic traits and short height. A total of 315 buds were irradiated in vitro with gamma rays in doses of 20 Gy and were subcultivated and evaluated in the field over 2 production cycles. The clones were evaluated to select.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.11.1
- DOI:
- 10.4238/2015.May.11.1
Characterization of abnormal epithelium after laser-assisted subepithelial keratectomy using in vivo confocal microscopy
Authors: J. Zuo, C.W. Zhang, X. Zhou, W. Wei and Y.L. Wang
This study compared the abnormal corneal epithelium after laser-assisted subepithelial keratectomy (LASEK) with dystrophic cornea using in vivo using confocal microscopy (IVCM) and examined the effects of the abnormal epithelium on postoperative recovery of uncorrected distance visual acuity (UDVA) and sub-basal nerve plexus regeneration. The UDVA and wou.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.11.7
- DOI:
- 10.4238/2015.May.11.7
Evolutionary tree reconstruction using structural expectation maximization and homotopy
Authors: Li Jand Guo M
The evolutionary tree reconstruction algorithm called SEMPHY using structural expectation maximization (SEM) is an efficient approach but has local optimality problem. To improve SEMPHY, a new algorithm named HSEMPHY based on the homotopy continuation principle is proposed in the present study for reconstructing evolutionary t.. Read More»
- Genet. Mol. Res. 6(3):
Bioinformatic analysis of the effect of type II diabetes on skin wound healing
Authors: K. Ge, J.J. Wu, L. Qian, M.J. Wu, F.L. Wang, B. Xu and T. Xie
We examined the relationship between type 2 diabetes and skin wound healing. GSE38396 was downloaded from the Gene Expression Omnibus database and preprocessed using the RMA function of the Affy package. Differentially expressed genes (DEGs) were identified using the limma package, then DAVID was applied to perform Gene Ontology functional annotation and .. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.11.12
- DOI:
- 10.4238/2015.May.11.12
Genetic diversity and historical demography of the narrow-range endemic Alpine toad, Scutiger liupanensis, in the Liupan Mountains of central China
Authors: L.-N. Su, H.-Z. Meng and X.-C. Li
The genetic diversity and historical demography of the narrow-range endemic Alpine toad, Scutiger liupanensis, in the Liupanshan National Forest Park of central China were estimated using cytochrome b and cytochrome c oxidase subunit I (COI) from 85 individuals from five local populations. Both the haplotype diversity (Hd ) and the nucleotide diversity (P.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.11.19
- DOI:
- 10.4238/2015.May.11.19
Clinical analysis of penehyclidine hydrochloride combined with hemoperfusion in the treatment of acute severe organophosphorus pesticide poisoning
Authors: M.J. Liang and Y. Zhang
This study aimed to observe the clinical curative effect of penehyclidine hydrochloride (PHC) combined with hemoperfusion in treating acute severe organophosphorus pesticide poisoning. We randomly divided 61 patients with severe organophosphorus pesticide poisoning into an experimental group (N = 31) and a control group (N = 30), and we compared the coma-.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.11.24
- DOI:
- 10.4238/2015.May.11.24
Low-level sequence variation in Toxoplasma gondii calcium-dependent protein kinases among different genotypes
Authors: J.L. Wang, N.Z. Zhang, S.Y. Huang, Y. Xu1,2, R.A. Wang and X.Q. Zhu
The causative agent of toxoplasmosis, Toxoplasma gondii, can infect virtually all nucleated cell types of warm-blooded animals. In this study, we examined the sequence variation in calciumdependent protein kinase 2 (CDPK2) genes among 13 T. gondii strains from different hosts and geographical locations. The results showed that the lengths of the complete .. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.11.28
- DOI:
- 10.4238/2015.May.11.28
TNF-�± -308 A/G and -238 A/G polymorphisms and susceptibility to glaucoma: a meta-analysis
Authors: Y.H. Lee and G.G. Song
The purpose of this study was to examine whether tumor necrosis factor-α (TNF-α) -308 A/G and -238 A/G polymorphisms confer susceptibility to glaucoma. A meta-analysis was conducted examining the association between TNF-α -308 A/G and -238 A/G polymorphisms and glaucoma. A total of 13 studies on TNF-α -308 A/G and 238 A/G polymorph.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.11.30
- DOI:
- 10.4238/2015.May.11.30