Bioinformatics
Bioinformatic analysis of miRNA expression patterns in TFF2 knock-out mice
Authors: Y. Yin, H.Q. Shan, W. Huang, Y.M. Wu, H. Lu and Y. Jin
Trefoil factors, which bear a unique 3-loop trefoil domain, are a family of small secretory protease-resistant peptides (7-12 kDa) discovered in the 1980s. Trefoil factor 2 (TFF2) is a unique member of trefoil factors family that plays important roles in gastrointestinal mucosal defense and repair. However, few studies have characterized the miRNA express.. Read More»
- Genet. Mol. Res. 13(4):
- 2014.October.20.26
- DOI:
- 10.4238/2014.October.20.26
Identification of marker genes in diabetic wounds by DNA microarray study
Authors: T. Ni1, N. Wang1, Z.G. Mao1 and M. Yao1,2
This study aimed to identify marker genes in diabetic wounds using a dataset based on a DNA microarray of dermal lymphatic endothelial cells, and our results provide a basic understanding of diabetic wounds through further study of these differentially expressed genes (DEGs). From the Gene Expression Omnibus database, we downloaded a gene expression micro.. Read More»
- Genet. Mol. Res. 12(4):
- DOI http://dx.doi.org/2013.November.7.9
- DOI:
- DOI http://dx.doi.org/10.4238/2013.November.7.9
Identification of UV-B-induced microRNAs in wheat
Authors: B. Wang*, Y.F. Sun*, N. Song, X.J. Wang, H. Feng, L.L. Huang and Z.S. Kang
MicroRNAs (miRNAs) play critical roles in post-transcriptional gene regulation and act as important endogenous regulators to various stressors. Ultraviolet-B (UV-B) radiation is a major factor influencing crop growth and development. In this study, we isolated a novel wheat miRNA, named Tae-miR6000, and confirmed its expression diversity after UV-B treatm.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.October.7.7
- DOI:
- 10.4238/2013.October.7.7
Antioxidant capacity and meat quality of broilers exposed to different ambient humidity and ammonia concentrations
Authors: F.X. Wei, X.F. Hu, R.N. Sa, F.Z. Liu, S.Y. Li and Q.Y. Sun
To investigate the effect of humidity and ammonia on the antioxidative capacities and meat qualities of broilers, 192 broilers were divided into 2 groups: high (H, 70 ppm) and low (L, 30 ppm) ammonia concentration. These groups were divided into 30% (Treatment humidity, T) and 60% (Control humidity, C) humidity, giving 4 treat.. Read More»
- Genet. Mol. Res. 13(2):
- 2014.April.17.8
- DOI:
- 10.4238/2014.April.17.8
Efficient detection of the V600E mutation of the BRAF gene in papillary thyroid carcinoma using multiplex allele-specific polymerase chain reaction combined with denaturing high-performance liquid chromatography
Authors: R.X. Gong1, Y.P. Gong1, J. Yang1, T. Wei1, J. Li-Ling2,3 and J.Q. Zhu1
Mutations in the V-raf murine sarcoma viral oncogene homolog B1 gene (BRAF) play an important role in the pathogenesis of papillary thyroid cancer (PTC). In this study, a BRAF V600E mutation was detected in formalin-fixed and paraffin-embedded PTC samples using multiplex allele-specific polymerase chain reaction and denaturing high-performance liquid chro.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.October.24.11
- DOI:
- 10.4238/2013.October.24.11
Effects of destrin pathway mutations on the gene expression profile
Authors: J.N. Xu, X. Liu, H. Wang, C.M. Hu, Q.H. Luo and Q.Q. Zhou
This study aimed to explore the interaction and crosstalk between pathways in response to destrin mutations. All the pathways from the MINT database were downloaded, a protein-protein interaction network was then constructed, and the crosstalk between pathways was investigated, in particular, the overlap of 2 significant pathw.. Read More»
- Genet. Mol. Res. 13(2):
- 2014.April.8.5
- DOI:
- 10.4238/2014.April.8.5
An efficient algorithm for finding attractors in synchronous Boolean networks with biochemical applications
Authors: D. Zheng, G. Yang, X. Li, Z. Wang and W.N.N. Hung
Self-organized systems, genetic regulatory systems and other living systems can be modeled as synchronous Boolean networks with stable states, which are also called state-cycle attractors (SCAs). This paper summarizes three classes of SCAs and presents a new efficient binary decision diagram based algorithm to find all SCAs of synchronous Boolean networks.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.October.18.4
- DOI:
- 10.4238/2013.October.18.4
Variability analysis of �Persian� acid lime tree selections using agronomic and molecular markers
Authors: M.G. Santos, O.S. Passos, W.S. Soares Filho, E.A. Girardi, A.S. Gesteira and C.F. Ferreira
‘Persian’ acid lime (PAL) is the most important triploid commercial citrus crop planted in the world. Little is known about the genetic variability of the selections used in Brazil. Therefore, 25 genotypes originating from the PAL, and three control species, Citrus sunki, C. limon, and C. aurantiifolia, were assessed using inter-simple sequenc.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.October.17.3
- DOI:
- 10.4238/2013.October.17.3
Genetic diversity of spineless Cereus jamacaru accessions using morphological and molecular markers
Authors: F.I.C. Oliveira, P.N. Bordallo, A.C.R. Castro and D. Correia
This is the first study to examine the genetic diversity of mandacaru cactus (Cereus jamacaru P. DC.). Plants of spineless mandacaru are commonly found in gardens and parks of urban areas in northeastern Brazil. In addition to exploring their ornamental potential, morphological, and genetic characterization may contribute to the development of plant mater.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.October.17.1
- DOI:
- 10.4238/2013.October.17.1
Association of insulin growth factor-1 receptor gene polymorphisms with genetic susceptibility to idiopathic short stature
Authors: Y. Yang, H. Huang,W. Wang, L. Yang, L.L. Xie and W. Huang
The association between single nucleotide polymorphisms (SNPs) in the insulin-like growth factor-1 receptor (IGF-1R) gene and susceptibility to idiopathic short stature (ISS) was investigated. Seven hundred and twelve Chinese children clinically diagnosed with ISS and 575 normal individuals were recruited between 2008 and 2011, and their SNPs were genotyp.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.October.18.14
- DOI:
- 10.4238/2013.October.18.14