Diabetes Mellitus
Analysis of Micro-RNAs and Gene Expression Profiles in Gestational Diabetes Mellitus: A Consensus Approach
Authors: R. Bhushan, A. Rani, D. Gupta, I. Khan, A. Tripati, R. P. Singh and K. D. Pawan
Gestational Diabetes Mellitus (GDM) is a metabolic disorder characterized by insulin resistance. Lack of complete mechanisms involved in its pathophysiology makes its early diagnosis and treatment a difficult task. Recently, micro-RNAs are associated with many diseases including GDM. Its high stability in biological fluids and the ability to modulate gene.. Read More»
- Genet. Mol. Res. 20(1):
Improvement of Exercise Intervention on Vascular Endothelial Functions during Prediabetes Mellitus
Authors: Shaobing Wang, Zhenghong Zhang, Yiping Liu, Zhengchao Wang
Prediabetes is considered to be an at a risk state, with an annualized 5-10% conversion rate of diabetes and the similiar proportion converting back to normoglycaemia. The global incidence of prediabetes is increasing and will reach to 471 million patients in 2030. The elevation of blood sugar is a continuum and hence prediabe.. Read More»
- Genet. Mol. Res. 16(4):
- gmr16039830
- DOI:
- 10.4238/gmr16039830
Association of CYP2C19*2 with hyperlipidemia in patients with the wild-type CYP2C9
Authors: K. Khalighi, G. Cheng, S. Mirabbasi, B. Khalighi, Y. Wu and W. Fan
Arachidonic acids are metabolized by cytochromes P450 (CYP450) to epoxyeicosatrienoic acids (EETs). EETs have many cardiovascular protective effects such as vasodilation, anti-hypertension, anti-inflammation, lipid-lowering effects, and favorable effects on glucose homeostasis. This study aimed to investigate whether gene poly.. Read More»
- Genet. Mol. Res. 16(3):
- gmr16039737
- DOI:
- 10.4238/gmr16039737
Clinical features of diabetes mellitus cases complicated by Burkholderia pseudomallei septicemia
Authors: H.B. Quan, T.Y. Li, Y.Y. Gao and D.X. Chen
The aim of this study was to analyze the clinical characteristics of diabetes mellitus patients with Burkholderia pseudomallei septicemia and evaluate strategies of diagnosis and treatment. The clinical characteristics, diagnosis, treatment, and prognosis of 39 diabetes mellitus patients with B. pseudomallei septicemia were re.. Read More»
- Genet. Mol. Res. 13(2):
- 2014.April.17.7
- DOI:
- 10.4238/2014.April.17.7
Polymorphic variations in manganese superoxide dismutase (MnSOD) and endothelial nitric oxide synthase (eNOS) genes contribute to the development of type 2 diabetes mellitus in the Chinese Han population
Authors: J.Y. Li, F. Tao, X.X. Wu, Y.Z. Tan, L. He and H. Lu
Impaired antioxidant defense increases the oxidative stress and contributes to the development of type 2 diabetes mellitus (T2DM). MnSOD and eNOS are important antioxidant enzymes. This aim of this study was to verify the association of MnSOD and eNOS tagSNPs with T2DM in a Chinese Han population. Four tagSNPs of MnSOD and eight tagSNPs of eNOS were detec.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.21.20
- DOI:
- 10.4238/2015.October.21.20
Quantitative candidate gene association studies of metabolic traits in Han Chinese type 2 diabetes patients
Authors: F.J. Wei, C.Y. Cai, P. Yu, J. Lv, C. Ling, W.T. Shi, H.X. Jiao, B.C. Chang, F.H. Yang, Y. Tian, M.S. Li, Y.H. Wang, L. Zou, J.M. Shi, L.M. Chen and W.D. Li
Recent genome-wide association studies have identified many loci associated with type 2 diabetes mellitus (T2DM), hyperuricemia, and obesity in various ethnic populations. However, quantitative traits have been less well investigated in Han Chinese T2DM populations. We investigated the association between candidate gene single.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.30.25
- DOI:
- 10.4238/2015.November.30.25
Role of mitochondrial DNA variants and copy number in diabetic atherogenesis
Authors: M.C. Chien W.T. Huang P.W. Wang C.W. Liou T.K. Lin C.J. Hsieh S.W. Weng
Hyperglycemia-induced reactive oxygen species production can cause diabetes and its complications, including atherosclerosis. The role of mitochondrial DNA variants and mitochondrial copy number in the pathogenesis of diabetic atherogenesis is not well understood. We examined 36 diabetic patients who had undergone amputation for diabetic foot and seven non-d.. Read More»
- Genet. Mol. Res. 11(3):
- 2012.September.17.4
- DOI:
- 10.4238/2012.September.17.4
Lack of association of C282Y and H63D mutations in the hemochromatosis (HFE) gene with diabetes mellitus type 2 in a case-control study of women in Brazil
Authors: K.B. Gomes, M.G. Carvalho, F.F. Coelho, I.F. Rodrigues, A.L. Soares, D.A. Guimar�£es and A.P. Fernandes
Hereditary hemochromatosis is one of the most common autosomal recessive diseases; it is characterized by excess absorption of iron. Clinically, the major challenge is to diagnose increased iron deposition before irreversible tissue damage has occurred. C282Y and H63D are the main mutations related to hereditary hemochromatosi.. Read More»
- Genet. Mol. Res. 8(4):
- vol8-4gmr663
- DOI:
- 10.4238/vol8-4gmr663
Association of PTPN22 gene polymorphism with type 1 diabetes mellitus in Chinese children and adolescents
Authors: H.W. Liu, R.Y. Xu, R.P. Sun, Q. Wang, J.L. Liu, W. Ge1and Z. Yu
Previous studies have indicated that the protein tyrosine phosphatase nonreceptor type 22 gene (PTPN22) is associated with type 1 diabetes (T1DM) in the Caucasian population. In the present study, we investigated the relationship between PTPN22 genetic polymorphisms and T1DM in Chinese children. A total of 202 children and adolescents with T1DM and 240 he.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.January.15.8
- DOI:
- 10.4238/2015.January.15.8
Genotype and phenotype correlations in diabetic patients in Uruguay
Authors: A. Mimbacas, L. GarcÃ?Âa, P. Zorrilla, M. Acosta, C. Airaudo, R. Ferrero, A. Pena, B. Simonelli, E. Soto, G. Vitarella, J. Fernandez and G. Javiel
To differentiate among different types of diabetes is becoming an increasingly challenging task. We investigated whether the patient’s genetic profile is useful to identify the particular type of diabetes, to determine the corresponding hyperglycemia pathogenesis and treat accordingly. Three hundred and thirty-eight diab.. Read More»
- Genet. Mol. Res. 8(4):
- vol8-4gmr667
- DOI:
- 10.4238/vol8-4gmr667