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Improvement of Exercise Intervention on Vascular Endothelial Functions during Prediabetes Mellitus

Author(s): Shaobing Wang, Zhenghong Zhang, Yiping Liu, Zhengchao Wang

Prediabetes is considered to be an at a risk state, with an annualized 5-10% conversion rate of diabetes and the similiar proportion converting back to normoglycaemia. The global incidence of prediabetes is increasing and will reach to 471 million patients in 2030. The elevation of blood sugar is a continuum and hence prediabetes cannot be considered an entirely benign status and present insulin resistance (IR) and β-cell dysfunction, so that the development of prediabetic complications and vascular endothelial dysfunction. Therefore, it is crucial to early recognition and treatment of prediabetic individuals. For prediabetic individuals, lifestyle modification is the cornerstone of diabetes prevention with evidence of a 40-70% relative risk reduction. In the review, we include the possible mechanism of IR-induced vascular endothelial dysfunction, and exercise intervention improving the vascular endothelial dysfunction. These results showed clearly positive effects of physical exercise intervention and provided a direct clinical evidence of the effectiveness of this approach for preventing early diabetes