Diabetes Mellitus
Identification of trends in scientific publications related to genetic polymorphisms in gestational diabetes mellitus
Authors: J.S. Gomes, L.B. Minasi, A.D. da Cruz and F.M. Rodrigues
Gestational diabetes is a genetic multifactorial systemic disease that has been extensively studied. Consequently, there is a large volume of scientific literature pertaining to genes associated with gestational diabetes. The aim of this study was to characterize the main trends in scientific publications focusing on the assoc.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027672
- DOI:
- 10.4238/gmr.15027672
Relationship between the polymorphisms in KCNQ1 and type 2 diabetes in Chinese Kazakh population
Authors: L.J. Cui, X.Y. Chang, L.Y. Zhu, G. Feng, T. Zhou, C.X. Zhang, K.Y. Chong and K. Sun
Recently genome-wide association studies on East Asian populations reported an association between diabetes and several single nucleotide polymorphisms (SNPs) in a 40-kb linkage disequilibrium block in intron 15 of KCNQ1. However, the association between KCNQ1 variants and type 2 diabetes mellitus (T2DM) in Chinese Kazakh popu.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027503
- DOI:
- 10.4238/gmr.15027503
Association between the rs4753426 polymorphism in MTNR1B with fasting plasma glucose level and pancreatic �²-cell function in gestational diabetes mellitus
Authors: Y. Zhan, C. Li, Q. Gao, J. Chen, S. Yu and S.G. Liu
We investigated the association between rs4753426 single nucleotide polymorphisms in the melatonin receptor 1B (MTNR1B) gene and the risk of developing gestational diabetes mellitus (GDM). A total of 516 gravidas (186 with GDM and 330 non-diabetic controls) were enrolled in the study. Genotype and allele frequencies of rs4753426 in the MTNR1B gene were de.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.3.1
- DOI:
- 10.4238/2015.August.3.1
Serum YKL-40 levels are associated with type 2 diabetes mellitus in patients with obstructive sleep apnea syndrome
Authors: L. Sun, J.Y. Liu and L.R. Li
Patients with obstructive sleep apnea syndrome (OSAS) have an increased risk for type 2 diabetes mellitus (T2DM). It has been recently demonstrated that serum YKL-40 levels, also named as human cartilage glycoprotein 39, are elevated in T2DM patients. The aim of this study was to determine whether serum YKL-40 levels are associated with T2DM in patients w.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.3.15
- DOI:
- 10.4238/2015.August.3.15
Hepatic phosphoenolpyruvate carboxykinase expression after gastric bypass surgery in rats with type 2 diabetes mellitus
Authors: J. Wu, S.S. Hou, W. Wang, M. Yin, N. Cheng, L.L. Ge, J.J. Yin and J. Xu
The objective of this study was to investigate the mRNA expression of hepatic phosphoenolpyruvate carboxykinase (PEPCK) after gastric bypass surgery (GBS) in rats with type 2 diabetic mellitus (T2DM). Thirty-six male Goto-Kakizaki rats, aged 12 weeks, were randomly divided into the GBS, sham operation with diet restriction (SO), and sham operation alone (.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.14.22
- DOI:
- 10.4238/2015.December.14.22
Effect of GSTM1, GSTT1, and GSTP1 IIe105Val polymorphisms on susceptiblity to gestational diabetes mellitus
Authors: Y.H. Qiu, Y.L. Xu and W.H. Zhang
We investigate the role of the GSTM1, GSTT1, and GSTP1 IIe105Val genetic polymorphisms in the susceptibility to gestational diabetes mellitus. A total of 223 pregnant women with gestational diabetes mellitus and 265 healthy pregnant women were examined at The Second Affiliated Hospital of Shaanxi University of Chinese Medicine.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027711
- DOI:
- 10.4238/gmr.15027711
MicroRNA profiling in cutaneous wounds of diabetic rats
Authors: Y.-F. Liu, M. Ding, D.-W. Liu, Y. Liu, Y.-G. Mao and Y. Peng
Despite years of effort, current therapies for diabetic wounds are still not fully efficacious. Emerging evidence has suggested that microRNAs (miRNAs) play key roles in multiple physiological and pathological processes in eukaryotes, and could potentially be powerful therapeutic tools. This study investigated the differential expression profiling of miRN.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.14.24
- DOI:
- 10.4238/2015.August.14.24
Association between matrix metallopeptidase 1 and type 2 diabetes mellitus coexisting with coronary heart disease in a Han Chinese population
Authors: Y.Z. Ma, Q.Y. Jiang and D.Q. Kong
Matrix metallopeptidase 1 (MMP-1) has been reported to be involved in the coexistence of type 2 diabetes mellitus (T2DM) and coronary heart disease (CHD). We sought to examine the association between the MMP-1 gene polymorphism and coexistence of T2DM and CHD in a Han Chinese population. We extracted genomic DNA from the perip.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027938
- DOI:
- 10.4238/gmr.15027938
Association between transcription factor 7-like 2 genetic polymorphisms and development of type 2 diabetes in a Chinese population
Authors: H.Y. Jia, Q.Z. Li and L.F. Lv
We conducted a hospital-based case-control study to evaluate the relationship between the transcription factor 7-like 2 (TCF7L2) rs7903146 polymorphism and type 2 diabetes mellitus risk in a Chinese population. Genotyping of TCF7L2 rs7903146 was carried out using the polymerase chain reaction-restriction fragment length polymo.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028223
- DOI:
- 10.4238/gmr.15028223
Association of TNF-�±, CTLA4, and PTPN22 polymorphisms with type 1 diabetes and other autoimmune diseases in Brazil
Authors: N.A.C. Tavares, M.M.S. Santos, R. Moura, J. Ara�ºjo, R.L. Guimar�£es, S. Crovella and L.A.C. Brand�£o
Type 1 diabetes mellitus (T1D) is a complex disorder characterized by an autoimmune response against human pancreatic beta-cells. Patients with T1D can also develop a response toward one or more other factors, such as in autoimmune thyroiditis (AITD) and celiac disease (CD). In the presence of T1D + AITD, the patient is diagnosed with autoimmune polygland.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.28.42
- DOI:
- 10.4238/2015.December.28.42