Diabetes Mellitus

Associations between INSR and MTOR polymorphisms in type 2 diabetes mellitus and diabetic nephropathy in a Northeast Chinese Han population

Authors: A.N. Zhu, X.X. Yang, M.Y. Sun, Z.X. Zhang and M. Li1,

We explored the associations of INSR and mTOR, 2 key genes in the insulin signaling pathway, and the susceptibility to type 2 diabetes mellitus and diabetic nephropathy. Three single-nucleotide polymorphisms (SNPs) (rs1799817, rs1051690, and rs2059806) in INSR and 3 SNPs (rs7211818, rs7212142, and rs9674559) in mTOR were genotyped using the Sequenom MassA.. Read More»

Genet. Mol. Res. 14(1):

2015.March.13.9

DOI:

10.4238/2015.March.13.9

Relationship between serum GAD-Ab and the genetic polymorphisms of GAD2 and type 2 diabetes mellitus

Authors: Q. Li, Z.R. Qiao, D.B. Liu, J.T. Zeng, J. Zhang, Y. Bo, H.Y. Zu, Q. Hu, X. Wu and S.S. Dong

In this study, we investigated the relationship between serum glutamic acid decarboxylase (GAD) autoantibody (Ab) levels and single nucleotide polymorphisms (SNPs) of the glutamic acid decarboxylase 2 (GAD2) 5'-untranslated region and the susceptibility to type 2 diabetes in the Han population. The distributions of patients with SNPs in the GAD2 5'-untran.. Read More»

Genet. Mol. Res. 14(2):

http://dx.doi.org/2015.April.10.10

DOI:

http://dx.doi.org/10.4238/2015.April.10.10

Promotive effect of comprehensive management on achieving blood glucose control in senile type 2 diabetics

Authors: S.-T. Yan, C.-X. Li, C.-L. Li, J. Li, Y.-H. Shao, Y. Liu, W.-W. Zhong, F.-S. Fang, B.-R. Sun and H. Tian

The aim of this study was to evaluate the control of blood glucose and glycosylated hemoglobin A1c (HbA1c) and its influencing factors, in elderly type 2 diabetic mellitus (T2DM) patients undergoing comprehensive management. After years of comprehensive prevention of and control measures for diabetes, elderly T2DM patients who were receiving long-term hea.. Read More»

Genet. Mol. Res. 14(2):

http://dx.doi.org/2015.April.10.16

DOI:

http://dx.doi.org/10.4238/2015.April.10.16

Evaluation of angiotensin-converting enzyme and adenosine deaminase polymorphisms in patients with type 2 diabetes mellitus

Authors: A.C.B. Domingos

Genet. Mol. Res. 9(2):

vol9-2ta030

DOI:

10.4238/vol9-2ta030

Relationship between a lipoprotein lipase gene polymorphism in placental tissue and insulin resistance in patients with gestational diabetes mellitus

Authors: D.D. Li, D.Y. Su, L. Xue, W. Gao and W.Y. Pang

The aim of this study was to investigate the relationship between a lipoprotein lipase (LPL) gene polymorphism in placental tissue and insulin resistance (IR) in patients with gestational diabetes mellitus. Using polymerase chain reaction-restriction enzyme fragment length polymorphism (PCR-RFLP) analysis, the LPL HindIII RFLP was examined in the placenta.. Read More»

Genet. Mol. Res. 14(3):

2015.July.14.1

DOI:

10.4238/2015.July.14.1

Staging of type 2 diabetes mellitus

Authors: S.L. Wu

There is currently no reported staging system for type 2 diabetes mellitus. Here, I attempted to stage type 2 diabetes mellitus in order to help clinicians, patients, and other interested individuals to effectively evaluate patient conditions... Read More»

Genet. Mol. Res. 14(1):

2015.March.20.22

DOI:

10.4238/2015.March.20.22

Upregulation of salivary �±2 macroglobulin in patients with type 2 diabetes mellitus

Authors: J.K. Feng, Y.F. Lu, J. Li, Y.H. Qi, M.L. Yi and D.Y. Ma

We investigated the expression of salivary α2-macroglobulin (α2-MG) in patients with type 2 diabetes mellitus (T2DM) to investigate its value for predicting damage to the salivary glands. A total of 116 patients with T2DM and 60 patients with impaired fasting glucose (IFG) were included in this study. Sixty health volunteers were enrolled as a.. Read More»

Genet. Mol. Res. 14(1):

2015.March.27.12

DOI:

10.4238/2015.March.27.12

Effects of ginsenoside Rg1 on glucose metabolism and liver injury in streptozotocin-induced type 2 diabetic rats

Authors: W. Tian, L. Chen, L. Zhang, B. Wang, X.B. Li, K.R. Fan, C.H. Ai, X. Xia, S.D. Li, Y. Li

Type 2 diabetes mellitus (T2-DM) is a chronic metabolic disorder characterized by high blood glucose levels. T2-DM patients suffer from many complications, such as diabetic fatty liver and diabetic nephropathy. The liver, the pivotal organ involved in both glucose and lipid metabolism, is primarily damaged in T2-DM patients, e.. Read More»

Genet. Mol. Res. 16(1):

gmr16019463

DOI:

10.4238/gmr16019463

Association between -1082G/A, -819C/T, and -592C/A genetic polymorphisms in IL-10 and risk of type 2 diabetes mellitus in a Chinese population

Authors: Q.Y. Dong, X.M. Liu, C.G. Liang, W.H. Du, Y.L. Wang, W.X. Li and G.Q. Gao

Type 2 diabetes mellitus is the most common form of endocrine disease in humans; genetic factors are known to contribute to the development of this disease. In this case-control study, we investigated the relationship between the -1082G/A, -819C/T, and -592C/A polymorphisms in interleukin 10 (IL-10) and the pathogenesis of typ.. Read More»

Genet. Mol. Res. 15(3):

gmr.15038559

DOI:

10.4238/gmr.15038559

Association between the PPAR�³ Pro12Ala polymorphism and risk of gestational diabetes mellitus: a meta-analysis

Authors: H.L. Shuai, X.Z. Lin, D.L. Chen, P. Li and X. Luo

The relationship between the Pro12Ala polymorphism of PPARγ and the risk of gestational diabetes mellitus remains unresolved. Here, we attempted to resolve this inconsistency. Case-control studies pertaining to the effect of the Pro12Ala polymorphism in the PPARγ protein and risk of gestational diabetes mellitus we.. Read More»

Genet. Mol. Res. 15(4):

gmr15047682

DOI:

10.4238/gmr15047682