Diabetes Mellitus
Cox-2 gene polymorphism and IL-6 levels in coronary artery disease
Authors: K.K. Ol, B. Agachan, U. Gormus2, B. Toptas and T. Isbir
Coronary artery disease is one of the leading causes of mortality and diabetes mellitus is one of its main risk factors due to microvascular and macrovascular complications, such as atherosclerosis. Atherosclerosis is now known to be an inflammatory process mediated by prostaglandins and several interleukins. As both are impor.. Read More»
- Genet. Mol. Res. 10(2):
- vol10-2gmr967
- DOI:
- 10.4238/vol10-2gmr967
Racial disparities in the association between diabetes mellitus-associated polymorphic locus rs4430796 of the HNF1�² gene and prostate cancer: a systematic review and meta-analysis
Authors: Y.Z. Xiang, S.B. Jiang, J. Zhao, H. Xiong, Z.L. Cui, G.B. Li and X.B. Jin
Polymorphism 17q12 rs4430796 within HNF1β is a genetic variant associated with both diabetes mellitus and prostate cancer, but findings on the correlations of rs4430796 with prostate cancer risk specifically are not in agreement, especially among diverse populations. To shed some light on the contradictory findin.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.August.28.3
- DOI:
- 10.4238/2014.August.28.3
RT-qPCR assay on the vitamin D receptor gene in type 2 diabetes and hypertension patients in Turkey
Authors: H.C. Vural1 and E. Maltas
RT-qPCR was used to analyze the vitamin D receptor (VDR) gene TaqI polymorphism in 100 Turkish patients with type 2 diabetes mellitus (T2DM) and hypertension compared with 100 healthy subjects, to determine whether VDR could be considered as one of the susceptibility genes for T2DM and hypertension. Genotyping was done with PC.. Read More»
- Genet. Mol. Res. 11(1):
- 2012.March.14.1
- DOI:
- 10.4238/2012.March.14.1
Correlation between the decrease of cholesterol efflux from macrophages in patients with type II diabetes mellitus and down-regulated CYP7A1 expression
Authors: L.D. Bao, C.Q. Li, R. Peng, X.H. Ren, R.L. Ma, Y. Wang and H.J. Lv
The purpose of this study was to examine the changes of cellular cholesterol efflux from macrophages in patients with type II diabetes mellitus (DM), and to determine the expression of CYP7A1, ABCG5, and LXRβ therein. We recruited 30 patients with type II DM (including 15 patients complicated with coronary heart disease and 15 patients with DM only) .. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.31.20
- DOI:
- 10.4238/2015.July.31.20
Genetic polymorphisms in extracellular superoxide dismutase Leu53Leu, Arg213Gly, and Ala40Thr and susceptibility to type 2 diabetes mellitus
Authors: Y.M. Yang, X.R. Xie and A.L. Jin
The most common type of endocrine disease is type 2 diabetes mellitus (T2DM); genetic factors contribute to the development to T2DM. In this study, we investigated the role of the Leu53Leu, Arg213Gly, and Ala40Thr polymorphisms in extracellular superoxide dismutase (EC-SOD) gene in the development of T2DM in a Chinese populati.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048418
- DOI:
- 10.4238/gmr15048418
Improved gastric emptying in diabetic rats by irbesartan via decreased serum leptin and ameliorated gastric microcirculation
Authors: L. He, Y. Sun, Y. Zhu, R. Ren, Y. Zhang and F. Wang
Diabetic gastroparesis (DG) is a common clinical complication of diabetes mellitus. Leptin may cause delayed gastric emptying in the central and peripheral pathways. Microcirculatory disturbances in the stomach make gastric smooth muscles and nerves hypoxic-ischemic, thereby impairing gastric motility. Irbesartan is an angiote.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.5.2
- DOI:
- 10.4238/2014.September.5.2
Analysis of selected glutathione S-transferase gene polymorphisms in Malaysian type 2 diabetes mellitus patients with and without cardiovascular disease
Authors: A. Etemad, R. Vasudevan, A.F.A. Aziz, A.K.M Yusof, S. Khazaei, N. Fawzi, S. Jamalpour, M. Arkani, N.A. Mohammad and P. Ismail
Type 2 diabetes mellitus (T2DM) is believed to be associated with excessive production of reactive oxygen species. Glutathione S-transferase (GST) polymorphisms result in decreased or absent enzyme activity and altered oxidative stress, and have been associated with cardiovascular disease (CVD). The present study assessed the .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15025845
- DOI:
- 10.4238/gmr.15025845
All-trans retinoic acid prevents the development of type 1 diabetes by affecting the levels of interferon gamma and interleukin 4 in streptozotocin-induced murine diabetes model
Authors: Y. Wang, Y.J. Zhong, Y.Y. Wang, J. Xing and Z.M. Wang
The aim of this study was to explore the molecular mechanism by which all-trans retinoic acid (ATRA) prevents type 1 diabetes mellitus (T1DM). Fifty ICR mice were randomly assigned to three groups: prevention group [N = 20; mice received 10 mg/kg ATRA daily for 5 days and then 60 mg/kg streptozotocin (STZ) for 5 days]; diabeti.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017522
- DOI:
- 10.4238/gmr.15017522
Association between the TRAIL single nucleotide polymorphism rs1131580 and type 2 diabetes mellitus in a Han Chinese population
Authors: M.Y. Yu, P.Q. Zhao, X.H. Yan, B. Liu, Q.Q. Zhang, R. Wang, C.H. Ma, X.H. Liang, F.L. Zhu and L.F. Gao
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is expressed in different tissues and cells, including the pancreas and lymphocytes, and it can selectively induce apoptosis in tumor cells but not in most normal cells. TRAIL plays critical roles in type 1 diabetes mellitus, and is involved in type 2 diabetes mellitus (T2DM). We recent.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.10.2
- DOI:
- 10.4238/2013.September.10.2
Genetic polymorphisms of the TLR4 gene and their association with susceptibility to type 2 diabetes mellitus in the Chinese population
Authors: X.D. Fu, X.Q. Sun, H.Y. Wang, J.F. Guo, G.Z. Zhang and Q.H. Xu
Toll-like receptor 4 (TLR4) is potentially an important gene affecting the susceptibility to type 2 diabetes mellitus (T2DM). The objective of this study was to evaluate whether genetic polymorphisms of the TLR4 gene are associated with T2DM susceptibility. This potential association was analyzed in 668 T2DM patients and 672 healthy controls by polymerase.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.19.13
- DOI:
- 10.4238/2013.September.19.13