Diabetes Mellitus
Polymorphism E23K (rs5219) in the KCNJ11 gene in Euro-Brazilian subjects with type 1 and 2 diabetes
Authors: S.W. Souza, L.P. Alcazar, P.A. Arakaki, I.C.R. Santos-Weiss, D. Alberton, G. Picheth and F.G.M. Rego
Insulin secretion is regulated by ATP-sensitive potassium channels (KATP). The potassium inwardly-rectifying channel, subfamily J, member 11 (KCNJ11) gene, located on chromosome 11p15.1, encodes the subunit Kir6.2 that forms the pore region of KATP channels in pancreatic β-cells. Among the single nucleotide polymorphisms .. Read More»
- Genet. Mol. Res. 16(2):
- gmr16029543
- DOI:
- 10.4238/gmr16029543
Bioinformatic analysis of endothelial progenitor cells exposed to folic acid in type 1 diabetes mellitus
Authors: D.N. Fang, X.D. He, X.H. Li, H. Jia, P.Y. Li, Q. Lu, Z. Quan and Q.L. Wang
We investigated the effects of type 1 diabetes mellitus (T1DM) on endothelial progenitor cells (EPCs) at the molecular level and assessed the therapeutic potential of folic acid (FA) in DM. We downloaded the gene expression profile of the EPCs from T1DM patients before and after treatment with FA and from healthy controls. We .. Read More»
- Genet. Mol. Res. 13(1):
- 2014.January.3.1
- DOI:
- 10.4238/2014.January.3.1
Prognostic and assessment value of hyperglycemia and glycosylated hemoglobin in critical patients
Authors: Z.L. Zhang, X.M. Che, Z.H. Bai, W.J. Bu, L. Bai and H.H. Pei
Hyperglycemia is common in critical patients and high blood glucose levels have a negative effect on their prognosis. The aim of this study was to investigate the effect of hyperglycemia and glycosylated hemoglobin (GHb) in critical patients. A total of 648 critical patients were enrolled in the study and received a random blo.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.January.24.8
- DOI:
- 10.4238/2014.January.24.8
Expression of high-mobility group box protein 1 in diabetic foot atherogenesis
Authors: C.F. Tsao, W.T. Huang, T.T. Liu, P.W. Wang, C.W. Liou, T.K. Lin,C.J. Hsieh and S.W. Weng
The role of high mobility group box 1 (HMGB1) has been demonstrated in stroke and coronary artery disease but not in peripheral arterial occlusive disease (PAOD). The pathogenesis of HMGB1 in acute and chronic vascular injury is also not well understood. We hypothesized that HMGB1 induces inflammatory markers in diabetic PAOD patients. We studied 36 diabe.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.4.10
- DOI:
- 10.4238/2015.May.4.10
Correlation between polymorphism of platelet alloantigen genes HPA-1-5 and type 2 diabetes complication by carotid atherosclerosis in a Chinese population
Authors: Y.H. Zhang, S.F. Xu, J. Zheng, H.S. Hong and L.M. Fan
We investigated the association between the polymorphism of human platelet alloantigen genes HPA-1-HPA-5 and the complication of type 2 diabetes mellitus (T2DM) by carotid atherosclerosis (CA) among Han people in Guiyang District, China. Ninety-nine T2DM patients were selected from the Affiliated Hospital of Guiyang Medical College and divided into a CA(+.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.4.19
- DOI:
- 10.4238/2015.May.4.19
Association of peroxisome proliferator-activated receptor-delta polymorphisms with sugar metabolism indices and tumor necrosis factor alpha level
Authors: X.J. Yu, B.L. Su, X.M. Wang, H.J. Feng and C.J. Jin
This study aims to investigate the association of peroxisome proliferator-activated receptor (PPAR) delta -87T/C polymorphism with several sugar metabolism indices and tumor necrosis factor α (TNF α) level. The body mass index (BMI), waist size, and levels of fasting plasma glucose, serum lipid, fasting insulin, TN.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.July.7.1
- DOI:
- 10.4238/2014.July.7.1
Association of the FABP2 Ala54Thr polymorphism with type 2 diabetes, obesity, and metabolic syndrome: a population-based case-control study and a systematic meta-analysis
Authors: Y. Liu, G. Wu, L. Han, K. Zhao, Y. Qu, A. Xu and Q. Huang
Previous studies have reported associations between the functional FABP2 Ala54Thr (rs1799883) polymorphism and type 2 diabetes mellitus (T2DM), obesity, and metabolic syndrome in different populations with conflicting results. We investigated the association between the FABP2 Ala54Thr polymorphism and T2DM (235 cases, 431 controls), obesity (377 cases, 43.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.February.6.19
- DOI:
- 10.4238/2015.February.6.19
The effects of resveratrol on cyclooxygenase-1 and -2, nuclear factor kappa beta, matrix metalloproteinase-9, and sirtuin 1 mRNA expression in hearts of streptozotocin-induced diabetic rats
Authors: A.S. Yar, S. Menevse and E. Alp
Resveratrol (RSV) has a beneficial role in the prevention of diabetes and alleviates some diabetic complications, such as cardiomyopathy. We investigated cyclooxygenase-1 (COX-1), COX-2, nuclear factor κB (NF-κB), matrix metalloproteinase-9 (MMP-9), and sirtuin 1 (SIRT1) mRNA expression levels in heart tissue after.. Read More»
- Genet. Mol. Res. 10(4):
- 2011.November.29.7
- DOI:
- 10.4238/2011.November.29.7
Influence of glutathione S-transferase polymorphisms on type-2 diabetes mellitus risk
Authors: M.A. Amer, M.H. Ghattas, D.M. Abo-ElMatty and S.H. Abou-El-Ela
Glutathione S-transferase (GST) protects cells against oxidative stress. We evaluated the effect of genetic polymorphisms of the GST gene family on the risk of developing type-2 diabetes mellitus and on glycemic control. We also investigated the effects of smoking combined with these polymorphisms on type-2 diabetes mellitus r.. Read More»
- Genet. Mol. Res. 10(4):
- 2011.October.31.14
- DOI:
- 10.4238/2011.October.31.14
Role of APN and TNF-�± in type 2 diabetes mellitus complicated by nonalcoholic fatty liver disease
Authors: X. Lin, Z. Zhang, J.M. Chen, Y.Y. Xu, H.R. Ye, J. Cui, Y. Fang,Y. Jin, D.R. Zhu and L. Yuan
Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disease caused by non-excessive alcohol consumption and is the most common cause of elevated levels of serum liver enzymes. We examined changes in adiponectin (APN) and tumor necrosis factor-a (TNF-a) in type 2 diabetes mellitus (T2DM) complicated by NAFLD and their relationships with insulin resis.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.10.1
- DOI:
- http://dx.doi.org/10.4238/2015.April.10.1