The effect of EPS to LPS injure RAW264.7 cell NF-?ºB and MAPK signaling pathway
Authors: Q.D. Jiang, X.G. Zhou, Xiao.Z, X.P. Li and F.R. Nie
This study effects of Echinacea polysaccharide(EPS) to Lipopolysaccharides(LPS) injure RAW264.7 cell NF-κB and MAPK signaling pathway. The test was divided into blank groupã?LPS group and 100 mu g/mL EPS + LPS group, The respectively extract Cytoplasm protein and nucleoprotein. After Gel electrophoresis, the Western .. Read More»
- Genet. Mol. Res. 16(4):
- gmr16039846
- DOI:
- 10.4238/gmr16039846
Decrypting the microRNA signatures in gastric cancer using high-throughput miRNA array coupled with systems biological approaches for precision medicine
Authors: Fehmida Bibi, Peter Natesan Pushparaj, Muhammad I. Naseer, Muhammad yasir, Esam I. Azhar
MicroRNAs (miRNAs) are non-coding small RNA molecules that regulate the differential expression of genes. The expression of miRNAs is dysregulated in various types of cancers, including Gastric Cancer (GC), and has both prognostic and diagnostic potential. To interpret the role of miRNA expression in GC, we evaluated the expre.. Read More»
- Genet. Mol. Res. 16(4):
- gmr16039845
- DOI:
- 10.4238/gmr16039845
Pseudo deficiency of acid ?±-glucosidase: a challenge in the newborn screening for Pompe diseases
Authors: Diana Rojas M?¡laga, Ana C. Brusius-Facchin, Kristiane Michelin-Tirelli, T?ªmis M. F?©lix, Jaqueline Schulte, Jamile Pereira, Eurico Camargo Neto, Claudio Sampaio Filho, Roberto Giugliani.
When a low activity of acid α-glucosidase (GAA) is found, particularly in newborn screening programs, to differentiate α-glucosidase pseudo deficiency from true Pompe disease is important and urgent, as the result generates parental stress and also because this differentiation drives decisions related to the manage.. Read More»
- Genet. Mol. Res. 16(4):
- gmr16039844
- DOI:
- 10.4238/gmr16039844
Single Nucleotide Polymorphisms associated with growth and carcass traits located on QTL Regions previously associated with Bovine Respiratory Disease
Authors: S. Mizell, S.L. Miller, A.M. Royer, K.J. Thornton, and M.D. Garcia
The objective of the current study was to evaluate single nucleotide polymorphisms (SNP) for potential growth and carcass trait associations located in two previously described quantitative trait loci (QTL) regions associated with bovine respiratory disease. A population of 323 crossbred steers sired by five purebred sire bree.. Read More»
- Genet. Mol. Res. 16(4):
- gmr16039843
- DOI:
- 10.4238/gmr16039843
Inheritance of Precocity and of Agronomic Characters in Soybean
Authors: F.G. Teixeira, O.T. Hamawaki, A.P.O. Nogueira, R.L. Hamawaki, C.L. Hamawaki, T.P. Mattos, I.C. Silveira and L.A. Medeiros
Precocious soybean cultivars enable crop rotation and low pressure to the biotic and abiotic factors. This study aimed to determinate the inheritance of characters related to precocity and agronomic characters in soybean segregating population, coming from contrasting genitors to cycle. The experiment was conducted at a gre.. Read More»
- Genet. Mol. Res. 16(4):
- gmr16039842
- DOI:
- 10.4238/gmr16039842
Identification of Klf6-Related Super Enhancer in Human Hepatoma (HepG2) Cells by CRISPR Technique
Authors: Kum Chol Ri*, Jong Su Kim, Chol Kim
The Klf6 gene is a tumor suppressor gene belonging to the family of the Klf gene and closely associated with tumor formation. Recently, super enhancers(SEs) have been shown to play a particularly important role in regulating cell identity and are attempting to evaluate the in vivo function of SEs. But direct functional evidenc.. Read More»
- Genet. Mol. Res. 16(4):
- gmr16039841
- DOI:
- 10.4238/gmr16039841
Intestinal Dysbiosis Increases the Incidence of Malignant Melanoma in Mice Model
Authors: Xiaomeng Ren, Xin Zhang, Yanyan Zhu, Yaser Gamallat, Abdo Meyiah, Shenhao Ma, Yi Xin
Antibiotic-induced disruption of the intestinal microbiota has serious consequences for human physiology. We conducted a microbial dysbiosis animal model to study and directly provide evidence for microbial dysbiosis contribution to malignant melanoma animal model. Females C57BL/6 wild-type (WT) mice injected with a limiting t.. Read More»
- Genet. Mol. Res. 16(4):
- gmr16039840
- DOI:
- 10.4238/gmr16039840
Genetic diversity between and within half-sib families of Brazil nut tree (Bertholletia excelsa Bonpl.) originating from native forest of the Brazilian Amazon
Authors: L.D. Giustina, A.B. Baldoni, F.D. Tardin, F.S. Gregolin, H. Tonini, L.G. Neves, L.P. Ribeiro, P.E. Teodoro
Brazil nut tree is a species of economic importance for the Amazon region, known for the commercialization of its almonds. The objective of this work was to study the genetic diversity among half-sib progenies from different Brazil nut trees present in native forest in the municipality of Itaúba, MT, belonging to the Br.. Read More»
- Genet. Mol. Res. 16(4):
- gmr16039839
- DOI:
- 10.4238/gmr16039839
Phenotypic, genotypic, and environmental correlations between characters in onion segregate populations obtained under different generations
Authors: D.L.M. Machado, J. A. de Freitas, J.M.Q. Luz, G. M. Maciel, A.P.O. Nogueira and E. di Camillo
Onion (Allium cepa L.) is the third most valuable vegetable crop worldwide and the third most produced in Brazil. The knowledge of the nature and the value of the relationship between the traits of interest is very important, since it is possible to select a main trait, with low heritability or difficult measurement, obtaining.. Read More»
- Genet. Mol. Res. 16(4):
- gmr16039838
- DOI:
- 10.4238/gmr16039838
Comparison Between Real-Time Polymerase Chain Reaction and DNA-Microarray in Detection and Identification of Mycobacterium Species
Authors: Asaad Gaber, Hzem Hamed, Essam Elsawy
Low-cost and low-density (LCD) DNA arrays offer an easy way to detect resistance as minimal laboratory instrumentation is needed. Nucleic acid-based amplification tests allow the rapid detection of Mycobacterium tuberculosis. Recently, a real-time PCR assay for M. tuberculosis complex was introduced. Real-Time PCR and DNA-micr.. Read More»
- Genet. Mol. Res. 16(4):
- gmr16039837
- DOI:
- 10.4238/gmr16039837