Polymorphisms of GSTM1 and GSTT1 genes in symptomatic atherosclerotic patients with hypertension and/or type 2 diabetes mellitus
Authors: R.S. Mascarenhas, F.R.B. Oliveira, J.F. Corr�ªa, K.S.F. e Silva, I.R. Costa, A.M. Barbosa, M.H. Lagares, F.L. Campedelli, M.P. de Morais, J.V.M. Martins, D.A. Rodrigues, e K.K.V.O. Moura
Atherosclerosis is a chronic inflammatory condition and originates due to the accumulation of lipids in the innermost layer of the arteries. It is often related due to other underlying diseases, such as systemic arterial hypertension and type 2 diabetes mellitus, which may be the cause or may contribute to a worse prognosis of.. Read More»
- Genet. Mol. Res. 16(4):
- gmr16039836
- DOI:
- 10.4238/gmr16039836
Evaluation of a cassava translationally controlled tumor protein (MeTCTP) reveals its function in thermotolerance of Escherichia coli and in vitro chaperone-like activity
Authors: Deyvid Novaes Marques, S�¡vio Pinho dos Reis, Cl�¡udia Regina Batista de Souza
The TCTP (Translationally controlled tumor protein) is a highly conserved protein family found in eukaryotic organisms, which has been associated to the performance of several functions at the cellular level, as those related to growth, development, and responses against environmental stresses. However, studies on TCTP from pl.. Read More»
- Genet. Mol. Res. 16(4):
- gmr16039835
- DOI:
- 10.4238/gmr16039835
Protein Z gene variants and risk of Idiopathic Recurrent Pregnancy Loss in Saudi Arabian women
Authors: Walid Zammiti, Sarra Said, Amani Shaman, Faisel Mohammed Abu-Duhier
Background: Protein Z (PZ) is a vitamin K-dependent plasma glycoprotein, it plays a key role in the physiologic inhibition of coagulation by acting as a cofactor in the inactivation of factor Xa. The relationship between PZ gene polymorphisms and pregnancy loss is controversial. To address this, we investigate the association .. Read More»
- Genet. Mol. Res. 16(4):
- gmr16039834
- DOI:
- 10.4238/gmr16039834
Effect of You-Gui-Wan on endometrial angiogenesis in controlled ovarian hyperstimulation mice model
Authors: Qiao-zhi Yin, Ji-Zhong Zhang, Li-min Li�Yu-lin Li, Li Huang, Nan Ning
Purpose: To explore the mechanism of You-Gui-Wan (YGW) in improving endometrial receptivity in mouse model of controlled ovarian hyperstimulation (COH). Methods: Sixty female mice with two consecutive oestrous cycles were randomly divided into COH model group (n = 50) and normal control group (n = 10). The COH model was crea.. Read More»
- Genet. Mol. Res. 16(4):
- gmr16039833
- DOI:
- 10.4238/gmr16039833
The correlation analysis of polymorphisms of Prion-Related Doppel (PRND) with prion (PRNP) alleles in Gansu Alpine Merino sheep
Authors: Yuan-zi Liu, Chun-lin Zhao, Yu-Ze Yang, Run Wu, Chuan Wang, Xue-Rui Wan1, Yan Wang
The interaction between the ovine prion protein gene (PRNP) and Doppel (PRND) gene polymorphisms is essential for understanding the role of prion proteins in scrapie. In this study, the blood genomic DNA samples of 111 Gansu Alpine Merino sheep were used to define the PRNP alleles and the haplotypes of PRND by PCR-SSCP (single.. Read More»
- Genet. Mol. Res. 16(4):
- gmr16039832
- DOI:
- 10.4238/gmr16039832
Association between polymorphisms in TLR4 gene targeted by microRNA-140 and cervical precancerous lesion in south Chinese women: a case control study
Authors: Chuican Huang , Zhongyi Li , Xingming Zhong, Yao Wang, Xingguang Ye, Lipeng Jing, Shiqi Huang, Qian Yin , Zhulin Miao, Zixing Zhou, Yang Liu, Xiaohong Ye, Yajing Han, Meiling Ou, Di Xiao , Congcong Guo, Chengli Zeng, Guang Yang, Chunxia Jing, Xiangcai Wei
Toll-like receptor 4 (TLR4), one of the key immune system effectors, plays a main role in immune recognition of cervical cancer. Micro-RNAs are involved in regulation of multiple important genes in the progression of cervical cancer. A case-control study of 592 people was conducted from Yun’an County, Yunfu City, Guangdo.. Read More»
- Genet. Mol. Res. 16(4):
- gmr16039831
- DOI:
- 10.4238/gmr16039831
Improvement of Exercise Intervention on Vascular Endothelial Functions during Prediabetes Mellitus
Authors: Shaobing Wang, Zhenghong Zhang, Yiping Liu, Zhengchao Wang
Prediabetes is considered to be an at a risk state, with an annualized 5-10% conversion rate of diabetes and the similiar proportion converting back to normoglycaemia. The global incidence of prediabetes is increasing and will reach to 471 million patients in 2030. The elevation of blood sugar is a continuum and hence prediabe.. Read More»
- Genet. Mol. Res. 16(4):
- gmr16039830
- DOI:
- 10.4238/gmr16039830
Alcohol metabolizing gene polymorphisms and their relationship with oral cancer risk and clinicopathological features
Authors: J.T. Takamori, M. Santos, G. T. Peterle, L. Rossi, O. A. Curioni, D. Gazito, L. L. Maia, I. D. Louro, M. M. de Oliveira, J. G. dos Santos, R. A. Moyses, P. M. Cury, T. N. Toporcov, J. L. Kanda, A. M. A. da Silva, M. B. de Carvalho
Oral cancer incidence is higher in individuals between the fifth and seventh decades of life, but some studies indicate a decreasing age trend. From the epidemiological point of view, alcohol consumption is associated with the emergence of oral cancer by interfering with mechanisms of DNA synthesis and repair. From a genetic s.. Read More»
- Genet. Mol. Res. 16(4):
- gmr16039829
- DOI:
- 10.4238/gmr16039829
A targeted NGS approach to identify a c.352C>G variant in the TWIST1 gene in an Albanian family with Saethre�Chotzen syndrome
Authors: Elena Manara, Denisa Guraj, Francesca Fanelli, Paolo E Maltese, Anila Babameto-Laku, Natale Capodicasa , Sandro Michelini, Bruno Amato, Matteo Bertelli
A targeted next generation sequencing (NGS) approach analysing contemporaneously 20 different genes mainly involved in craniosynostosis was adopted to molecularly diagnose the family of a 2-years old girl affected by Saethre–Chotzen syndrome, a syndromic form of craniosynostosis. The identified pathogenic variant in the .. Read More»
- Genet. Mol. Res. 16(4):
- gmr16039828
- DOI:
- 10.4238/gmr16039828
Promotion of apoptosis in high glucose-activated hepatic stellate cells by GLP-1 receptor agonist and its potential mechanism.
Authors: Lingkang Wu, Yingchao Liu, Liangliang Shi, Bingbing Zhang, Ana Carolina Picolo Pasian and Andrei Moroz
This study aimed to investigate the stimulatory effect of glucagon-like peptide 1 (GLP-1) receptor agonist (GLP-1RA) on the apoptosis of hepatic stellate cells (HSCs) activated by high glucose, and to explore the underlying molecular mechanism with a focus on the c-Jun N-terminal kinase (JNK) and extracellular signal-related k.. Read More»
- Genet. Mol. Res. 16(4):
- gmr16039818
- DOI:
- 10.4238/gmr16039818