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Human Genetics   Research Article
Expression of the stem cell factor in fibroblasts, endothelial cells, and macrophages in periapical tissues in human chronic periapical diseases

Authors: S.Q. Shen, R. Wang and S.G. Huang

Stem cell factor (SCF), an important stem cell cytokine, has multiple functions. Fibroblasts (FBs), mature mast cells, endothelial cells (ECs), and eosinophil granulocytes can produce SCF in the inflammatory process. Therefore, we aimed to observe SCF expression in FBs, ECs, and macrophages (MPs) in periapical tissues in human.. Read More»

Genet. Mol. Res. 16(1): gmr16019394

DOI: 10.4238/gmr16019394

Human Genetics   Research Article
MiR-214 regulates oral cancer KB cell apoptosis through targeting RASSF5

Authors: T.K. Li, K. Yin, Z. Chen, Y. Bao and S.X. Zhang

Ras association domain family member 5 (RASSF5), a member of the Ras association domain family, induces cell apoptosis by phosphorylating FOXO3a, which triggers target gene BIM (pro-apoptotic factor) activation. MiR-214 is overexpressed in oral cancer tissue, indicating its possible involvement in oral cancer pathogenesis. Bio.. Read More»

Genet. Mol. Res. 16(1): gmr16019327

DOI: 10.4238/gmr16019327

Plant Genetics   Research Article
Establishment and application of molecular ID in the main inbred lines of Chinese cabbage

Authors: X.X. Zhang, X.B. Tang, Y. Liu and Y.W. Zhang

Chinese cabbage is an important cruciferous vegetable in China. The differences in the morphology and other characteristics of the different varieties of Chinese cabbage are generally caused by their different genes. Using the simple sequence repeat (SSR) DNA molecular markers is an effective way to identify different genotype.. Read More»

Genet. Mol. Res. 16(1): gmr16019144

DOI: 10.4238/gmr16019144

Plant Genetics   Research Article
Selection of experimental strawberry (Fragaria x ananassa) hybrids based on selection indices

Authors: S.D. Vieira, D.C. de Souza, I.A. Martins, G.H.M.R. Ribeiro, L.V. Resende, A.K.L. Ferraz, A.G. Galv�£o and J.T.V. de Resende

The strawberry (Fragaria x ananassa Dutch.), is the only vegetable belonging to the rosacea family. All strawberry species have now emerged from wild species and belong to the genus Fragaria, being that this genus presents more than 45 described species, and only 11 are considered natural species. Due to the octoploid nature o.. Read More»

Genet. Mol. Res. 16(1): gmr16019052

DOI: 10.4238/gmr16019052

Microbial Genetics   Research Article
Immunohistochemical localization of sex hormone receptors in two Raillietina tapeworms

Authors: L. Chen, Y.M. Sun, L. Mu, Y. Zeng, H.Y. Li and T.H. Yang

Sex hormone receptors play critical roles in development and reproduction. However, it is not known whether they exist in Raillietina tapeworms, and if they do, whether they have a similar function to that in vertebrates. We examined the immunohistochemical distributions of androgen receptors (ARs), estrogen receptors (ERs), a.. Read More»

Genet. Mol. Res. 16(1): gmr16019033

DOI: 10.4238/gmr16019033

Plant Genetics   Research Article
Effect of increased UV-B radiation on carotenoid accumulation and total antioxidant capacity in tobacco (Nicotiana tabacum L.) leaves

Authors: J. Shen, C.Q. Jiang, Y.F. Yan, B.R. Liu and C.L. Zu

Carotenoids are important components of plant antioxidant systems, which protect photosystems from photooxidative destruction during ultraviolet-B (UV-B) exposure. The influence of carotenoids on total antioxidant capacity (TAC) of plants has rarely been studied. In this study, tobacco (Nicotiana tabacum L., ‘K326’.. Read More»

Genet. Mol. Res. 16(1): gmr16018438

DOI: 10.4238/gmr16018438

Human Genetics   Research Article
GSTM1 polymorphism in patients with clinical manifestations of atherosclerosis

Authors: D.A. Rodrigues, J.V.M. Martins, K.S.F. e Silva, I.R. Costa, M.H. Lagares, F.L. Campedelli, A.M. Barbosa, M.P. de Morais and K.K.V.O. Moura

Atherosclerosis is characterized by lesions, called atheroma or atheromatous plaques, in the inner layer of blood vessels, which block the vascular lumen and weaken the underlying tunica media. Several modifiable and non-modifiable risk factors for the development of atherosclerosis exist. The modifiable risk factors include h.. Read More»

Genet. Mol. Res. 16(1): gmr16019101

DOI: 10.4238/gmr16019101

Bioinformatics   Review Article
Bioinformatics: an overview and its applications

Authors: W.J.S. Diniz and F. Canduri

Technological advancements in recent years have promoted a marked progress in understanding the genetic basis of phenotypes. In line with these advances, genomics has changed the paradigm of biological questions in full genome-wide scale (genome-wide), revealing an explosion of data and opening up many possibilities. On the ot.. Read More»

Genet. Mol. Res. 16(1): gmr16019645

DOI: 10.4238/gmr16019645