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Plant Genetics   Research Article
Expression of metallothionein type 2 and 3 genes in Prosopis glandulosa leaves treated with copper

Authors: C. Michel-Lopez, O. Zapata-P�©rez, D. Gonz�¡lez-Mendoza,O. Grimaldo-Juarez, C. Cece�±a-Duran, O. Tzintzun-Camacho

For a better understanding of the strategies that are used by Prosopis glandulosa in heavy metal tolerance, the present study evaluated the gene expression of three metallothioneins (MTs; PgMt2-1, PgMt2, and PgMt3) in plants exposed to sub-lethal concentrations of copper. The PgMt2-1, PgMt2, and PgMt3 sequences were homologous.. Read More»

Genet. Mol. Res. 16(1): gmr16019490

DOI: 10.4238/gmr16019490

Human Genetics   Research Article
Association between the interleukin-1�² C-511T polymorphism and periodontitis: a meta-analysis in the Chinese population

Authors: H.F. Wang, F.Q. He, C.J. Xu, D.M. Li, X.J. Sun, Y.T. Chi and W. Guo

The association between the interleukin-1 beta (IL-1β) C-511T (or rs16944) polymorphism and periodontitis remains inconclusive, even though there have been previous studies on this association. To assess the effects of IL-1β C-511T variants on the risk of development of periodontitis, a meta-analysis was performed in.. Read More»

Genet. Mol. Res. 16(1): gmr16019315

DOI: 10.4238/gmr16019315

Plant Genetics   Research Article
Multivariate statistics applied to the reaction of common bean plants to parasitism by Meloidogyne javanica

Authors: L.N.S. Santos, P.D.S. Cabral, G.A.R. Neves, F.R. Alves, M.B. Teixeira1, F.N. Cunha1 N.F. Silva

The availability of common bean cultivars tolerant to Meloidogyne javanica is limited in Brazil. Thus, the present study aimed to evaluate the reactions of 33 common bean genotypes (23 landrace, 8 commercial, 1 susceptible standard and 1 resistant standard) to M. javanica, employing multivariate statistics to discriminate the .. Read More»

Genet. Mol. Res. 16(1): gmr16019420

DOI: 10.4238/gmr16019420

Microbial Genetics   Research Article
Effects of miRNA-143 and the non-coding RNA MALAT1 on the pathogenesis and metastasis of HeLa cells

Authors: L. Zhang, H.E.X.D. Niyazi, H.R. Zhao, X.P. Cao, M.N.S. Abudula, W.J. Ye, S.A. Zhang, R.H.M. Yiming, Y. Zhang, W.P. Su, R. Chen, Y. Ouyang, N. Miao and Y.X. Bao

Cervical cancer is a common female malignancy of global dimensions. MicroRNAs (miRNAs) play crucial roles in the development, differentiation, proliferation, and apoptosis of tumors. The non-coding RNA MALAT1 participates in various physiological processes that are important for proper functioning of the body. Here, we analyze.. Read More»

Genet. Mol. Res. 16(1): gmr16019269

DOI: 10.4238/gmr16019269

Human Genetics   Research Article
Gene expressions levels of 14-3-3a, NKCCla, APO-14, and Na+-K+-ATPase�² in gill tissue of Mugil cephalus acclimated to low salinity

Authors: L. Li, M. Jiang and X.Q. Shen

Fishes adapt to salinity changes primarily through osmotic pressure regulation, a process often associated with several genes, including 14-3-3a, NKCCla, APO-14, and Na+-K+-ATPaseβ. The present study investigated the differential expression of genes 14-3-3a, NKCCla, APO-14, and Na+-K+-ATPaseβ in the gill tissue of Mu.. Read More»

Genet. Mol. Res. 16(1): gmr16019444

DOI: 10.4238/gmr16019444

Human Genetics   Research Article
Inhibition of SHH pathway mechanisms by arsenic trioxide in pediatric medulloblastomas: a comprehensive literature review

Authors: P.H.S. Klinger, A.F. Andrade, L.E.A. Delsin, R.G.P. Queiroz, C.A. Scrideli, L.G. Tone and E.T. Valera

Recent innovations in the genomic understanding of medulloblastomas have provided new ways to explore this highly invasive malignant brain cancer arising from the cerebellum. Among the four different medulloblastoma subgroups described to date, the sonic hedgehog (SHH) genetic pathway is the pathway activated in the tumorigene.. Read More»

Genet. Mol. Res. 16(1): gmr16019412

DOI: 10.4238/gmr16019412

Plant Genetics   Research Article
Antifungal activity, yield, and composition of Ocimum gratissimum essential oil

Authors: F.B.M. Mohr, C. Lermen, Z.C. Gazim, J.E. Gon�§alves, O. Alberton

Ocimum gratissimum L. or clove basil, belongs to the Lamiaceae family, has various desirable uses and applications. Beyond its aromatic, seasoning, and medicinal applications, this plant also has antimicrobial activity. This study was aimed at assessing the antifungal activity, yield, and composition of the essential oil (EO) .. Read More»

Genet. Mol. Res. 16(1): gmr16019542

DOI: 10.4238/gmr16019542

Human Genetics   Research Article
Mutations in codons 12 and 13 of K-ras exon 2 in colorectal tumors of Saudi Arabian patients: frequency, clincopathological associations, and clinical outcomes

Authors: J. Zekri, A. Al-Shehri, M. Mahrous, S. Al-Rehaily, T. Darwish, S. Bassi, H. El Taani, A. Al Zahrani, S. Elsamany, J. Al-Maghrabi and B.B. Sadiq

Mutations in codons 12/13 of K-ras exon 2 are associated with reduced benefit from anti-epidermal growth factor receptor antibody treatment for metastatic colorectal cancer (CRC). Here, we evaluated the frequency of K-ras mutations and their relationship with clinicopathological features and treatment outcomes in Saudi Arabian.. Read More»

Genet. Mol. Res. 16(1): gmr16019369

DOI: 10.4238/gmr16019369