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Human Genetics   Research Article
BMP6 and BMP4 expression in patients with cancer-related anemia and its relationship with hepcidin and s-HJV

Authors: Y.J. Shi and X.T. Pan

In the present study, we investigated BMP6 and BMP4 expression in patients with cancer-related anemia (CRA) as well as its relationship with hepcidin and s-HJV. The avidin-biotin system enzyme-linked immunosorbent assay was used to test serum levels of BMP6, BMP4, s-HJV, and hepcidin in 53 cancer patients with anemia and 52 control cancer patients without.. Read More»

Genet. Mol. Res. 15(1): gmr.15017130

DOI: 10.4238/gmr.15017130

Human Genetics   Research Article
Prevalence of human papillomavirus genotypes among women with cervical lesions in the Shaanxi Province of China

Authors: J. Li, Y.Y. Wang, X. Nan, X.F. Tian, T. Yan, P. Wang, Y. Yin, Y. Liu, R. Yuan, G.Q. Wang and Y.L. Fu

This study aimed to investigate human papilloma virus (HPV) genotypes among women with cervical lesions in Shaanxi Province, China, to obtain information regarding cervical lesion prevention and treatment. The study included 4508 HPV-positive subjects; cervical swab specimens were collected and tested for HPV infection status and HPV genotypes using polym.. Read More»

Genet. Mol. Res. 15(1): gmr.15017181

DOI: 10.4238/gmr.15017181

Medical Genetics   Research Article
Molecular phylogeny of Lathyrus species: insights from sequence-related amplified polymorphism markers

Authors: S. Marghali, A. Touati, M. Gharbi, D. Sdouga and N. Trifi-Farah

Sequence-related amplified polymorphism (SRAP) markers were used to evaluate the intra- and interspecific variation among 40 Lathyrus genotypes (four species) (Fabaceae). Ten SRAP primer combinations resulted in a total of 94 bands, and they exhibited high interspecific variability. The genetic differentiation among Lathyrus, estimated using AMOVA, was hi.. Read More»

Genet. Mol. Res. 15(1): gmr.15017198

DOI: 10.4238/gmr.15017198

Human Genetics   Research Article
Expression of TRPM8 in diabetic rats and its relationship with visceral pain stimulation

Authors: J. Liu, S.L. Dong, N. Li, B.S. Ouyang and F. Qi

Transient receptor potential cation channel, subfamily M, member 8 (TRPM8) is a nonselective cation channel and a candidate for cold sensation signaling, but the relationship between TRPM8 and diabetes remains unclear. In the present study, we determined the expression levels of TRPM8 messenger RNA (mRNA) and the levels of the TRPM8 protein in the bladder.. Read More»

Genet. Mol. Res. 15(1): gmr.15017219

DOI: 10.4238/gmr.15017219

Human Genetics   Research Article
Association of MMP3 genotype with susceptibility to frozen shoulder: a case-control study in a Chinese Han population

Authors: Q. Xu, P.Y. Gai, H.L. Lv, G.R. Li and X.Y. Liu

Genetic factors may play an important role in frozen shoulder etiology, which may involve matrix metalloproteinase-3 (MMP3) gene polymorphisms. In this study, we examined single nucleotide polymorphisms in MMP3 for their association with frozen shoulder susceptibility in a Chinese Han population. The rs591058, rs650108, and rs679620 polymorphisms in the M.. Read More»

Genet. Mol. Res. 15(1): gmr.15017228

DOI: 10.4238/gmr.15017228

Medical Genetics   Research Article
Role of ERCC2 and ERCC3 gene polymorphisms in the development of osteosarcoma

Authors: X. Ma, Y. Zhang, T.S. Sun and J.H. Yao

We conducted a case-control study to investigate the role of common SNPs in ERCC2 (rs13181 and rs1799793) and ERCC3 (rs4150441 and rs4150506) in the development of osteosarcoma. A 1:2 matched case-control study was conducted. Between January 2012 and December 2013, 141 patients with pathologically diagnosed osteosarcoma and 282 controls were recruited in .. Read More»

Genet. Mol. Res. 15(1): gmr.15017302

DOI: 10.4238/gmr.15017302

Human Genetics   Research Article
Association between the PADI4 -94G/A polymorphism and rheumatoid arthritis: a meta-analysis in the Chinese population

Authors: H.X. Chang, B. Zhu, J.H. Yao, J. Wu, J. Wang and W. Sun

Although a number of studies have been conducted on the association between the peptidylarginine deiminase (PADI4) -94G/A polymorphism and rheumatoid arthritis (RA) in the Chinese population, the association remains elusive and controversial. To clarify the impact of the PADI4 -94G/A polymorphism on the risk of RA, a meta-analysis was performed in the Chi.. Read More»

Genet. Mol. Res. 15(1): gmr.15017391

DOI: 10.4238/gmr.15017391

Microbial Genetics   Research Article
Molecular characterization of carbapenemase genes in Acinetobacter baumannii in China

Authors: F. Fang, S. Wang, Y.X. Dang, X. Wang and G.Q. Yu

Acinetobacter baumannii is an aerobic non-motile Gram-negative coccobacillus, and it is one of the most important nosocomial pathogens worldwide. The aim of this study was to determine the molecular epidemiology of the outbreak strains. Between March 2011 and March 2014, a total of 205 strains of A. baumannii were isolated from patients at the Nanyang Cit.. Read More»

Genet. Mol. Res. 15(1): gmr.15017432

DOI: 10.4238/gmr.15017432