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Human Genetics   Research Article
Effect of atmospheric fine particles on epidermal growth factor receptor mRNA expression in mouse skin tissue

Authors: X. Han, W.L. Liang, Y. Zhang, L.D. Sun and W.Y. Liang

We investigated the effect of atmospheric fine particles on epidermal growth factor receptor (Egfr) mRNA expression in mouse skin tissue and explored the effect of atmospheric fine particles on skin aging. Forty female BALB/c mice were randomly divided into four groups (each comprising 10 mice) as follows: a saline control gro.. Read More»

Genet. Mol. Res. 15(1): gmr.15017188

DOI: 10.4238/gmr.15017188

Animal Genetics   Research Article
Effects of tail docking on the expression of genes related to lipid metabolism in Lanzhou fat-tailed sheep

Authors: Y. Yue, X. Cheng, S.G. Zhao, Z. Liu, L.S. Liu, R. Zhou, J.P. Wu and M.A. Brown

To evaluate stearoyl-CoA desaturase (SCD), hormone-sensitive lipase (HSL), lipoprotein lipase (LPL), and peroxisome proliferator-activated receptor (PPARγ) expression in Lanzhou fat-tailed sheep (with and without docked tails), 18 rams were randomly divided into two equal groups (docked group, LT; control group, LC). The.. Read More»

Genet. Mol. Res. 15(1): gmr.15017323

DOI: 10.4238/gmr.15017323

Human Genetics   Research Article
Relationship between the expression of Notch1 and EZH2 and the prognosis of breast invasive ductal carcinoma

Authors: L. Zhao, Q.Y. Zhang, X. Luan, X. Huang, S. Zhao and H. Zhao

We determined whether the coexpression of Notch1 and EZH2 influences the progression and prognosis of breast invasive ductal carcinoma. Using the c2 test, a significant difference was found between high and low expression of Notch1 in terms of lymph node, hormone receptor, and p53 expression (P < 0.05). Moreover, a signific.. Read More»

Genet. Mol. Res. 15(1): gmr.15017464

DOI: 10.4238/gmr.15017464

Medical Genetics   Research Article
A fast and simple method for the polymerase chain reaction-based sexing of livestock embryos

Authors: K.C.S. Tavares, I.S. Carneiro, D.B. Rios, C. Feltrin, A.K.C. Ribeiro, S. Gaud?ªncio-Neto, L.T. Martins, L.H. Aguiar, C.R. Lazzarotto, C.E.M. Calder?³n, F.E.M. Lopes, L.P.R. Teixeira, M. Bertolini and L.R. Bertolini

Embryo sexing is a powerful tool for livestock producers because it allows them to manage their breeding stocks more effectively. However, the cost of supplies and reagents, and the need for trained professionals to biopsy embryos by micromanipulation restrict the worldwide use of the technology to a limited number of speciali.. Read More»

Genet. Mol. Res. 15(1): gmr.15017476

DOI: 10.4238/gmr.15017476

Medical Genetics   Research Article
Significance of TNF-?± and IL-6 expression in invasive pituitary adenomas

Authors: J.L. Wu, J.Y. Qiao and Q.H. Duan

The aim of this study was to investigate expression of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in invasive pituitary adenomas (IPAs). The streptavidin peroxidase immunohistochemical method was employed to detect their expression in 40 cases of IPA and 40 of non-invasive pituitary adenoma (NIPA). TNF-α and IL-6 were found.. Read More»

Genet. Mol. Res. 15(1): gmr.15017502

DOI: 10.4238/gmr.15017502

Human Genetics   Research Article
Sperm quality and DNA damage in men from Jilin Province, China, who are occupationally exposed to ionizing radiation

Authors: D.D. Zhou, J.L. Hao, K.M. Guo, C.W. Lu and X.D. Liu

Long-term radiation exposure affects human health. Ionizing radiation has long been known to raise the risk of cancer. In addition to high doses of radiation, low-dose ionizing radiation might increase the risk of cardiovascular disease, lens opacity, and some other non-cancerous diseases. Low- and high-dose exposures to ioniz.. Read More»

Genet. Mol. Res. 15(1): gmr.15018078

DOI: 10.4238/gmr.15018078

Medical Genetics   Research Article
Reply to commentary by G. Sikri and S. Dua on the article â??Correlation between single nucleotide polymorphisms in hypoxia-related genes and susceptibility to acute high-altitude pulmonary edemaâ? published in Genetics and Molecular Research 14 (3): 11562-11572 to the letter published in Genet. Mol. Res. 14 (4): 15904-15905

Authors: L.J. Wu

The object in this study was a Han Chinese population in Lhasa, with 3658 m in altitude from Chengdu, which has 505 m in altitude by air. Within 24 to 48 h before the subjects arrived in the plateau, they completed a basic situation questionnaire, under the guidance of medical staff. Within 24 to 48 h after they reached the plateau, the subjects completed.. Read More»

Genet. Mol. Res. 15(1): gmr.15016155

DOI: 10.4238/gmr.15016155

Medical Genetics   Research Article
Correlation between serum IL-16 and atopic dermatitis

Authors: H.Y. Zheng, L. Zhao, C.X. Li and S.H. Li

This study aims to investigate the correlation between allergic sensitization of atopic dermatitis (AD) patients and their serum interleukin (IL)-16 levels. AD patients, healthy volunteers, and patients with psoriasis (N = 80, 35, 20, respectively) were tested for serum IL-16 and total and specific IgE levels by enzyme-linked .. Read More»

Genet. Mol. Res. 15(1): gmr.15016556

DOI: 10.4238/gmr.15016556