Association between IL-1�± rs17561 and IL-1�² rs1143634 polymorphisms and periodontitis: a meta-analysis

Authors: W.T. Yin, Y.P. Pan and L. Lin

Genetic variations in human interleukin-1 (IL-1) genes are known to be involved in inflammatory disorders. The rs17561 and rs1143634 polymorphisms of IL-1α and IL-1β, respectively, have been increasingly recognized as important regulators in the development of periodontitis. However, the existence of a specific association remains controversial.. Read More»

Genet. Mol. Res. 15(1): gmr.15017325

DOI: 10.4238/gmr.15017325

Transgenic rice expressing a cassava (Manihot esculenta Crantz) plasma membrane gene MePMP3-2 exhibits enhanced tolerance to salt and drought stresses

Authors: Y. Yu1,2*, Y.C. Cui1*, C. Ren1,2, P.S.C.F. Rocha1, M. Peng3, G.Y. Xu4, M.L. Wang1 and X.J. Xia1

Plasma membrane proteolipid 3 (PMP3) is a class of small hydrophobic proteins found in many organisms including higher plants. Some plant PMP3 genes have been shown to respond to abiotic stresses and to participate in the processes of plant stress tolerance. In this study, we isolated the cassava (Manihot esculenta Crantz) MePMP3-2 gene and functionally c.. Read More»

Genet. Mol. Res. 15(1): gmr.15017336

DOI: 10.4238/gmr.15017336

Effect of co-culturing human primary basic fibroblasts with respiratory syncytial virus-infected 16-HBE cells

Authors: J.-H. Wang, L.-H. Sun, S.-K. Huang and A.-H. Chen

This study investigated the effects induced by co-culturing human primary basic fibroblasts (HPBFs) with 16-human bronchial epithelial cells (16-HBE) infected with respiratory syncytial virus (RSV), in particular the transformation of HPBFs into myofibroblasts and secretion of extracellular matrix proteins. HPBFs were co-cultured with 16-HBE cells infecte.. Read More»

Genet. Mol. Res. 15(1): gmr.15017339

DOI: 10.4238/gmr.15017339

Molecular cloning and expression analysis of MAT1 gene in black tiger shrimp (Penaeus monodon)

Authors: Y. Wang1,2*, M.J. Fu1,3*, C. Zhao1,3, W.Y. Bao3, F.L. Zhou1,3, Q.B. Yang1,3,4, S.G. Jiang1,3 and L.H. Qiu1,3

MAT1 (ménage à trois 1), an assembly factor and targeting subunit of the CDK-dependent kinase (CAK), can regulate the cell cycle, transcription, and DNA repair. This study was intended to investigate the role of MAT1 in the reproductive maturation of black tiger shrimp (Penaeus monodon). In this study, the P. monodon MAT1 (PmMAT1) gene was i.. Read More»

Genet. Mol. Res. 15(1):

Cyclic adenosine monophosphate-protein kinase A signal pathway may be involved in pulmonary aquaporin-5 expression in ischemia/reperfusion rats following deep hypothermia cardiac arrest

Authors: Z.Y. Wu1*, Y. Yao2*, R. Hu1, F.F. Dai1, H. Zhang1 and Z.F. Mao1

We investigated the effects of cyclic adenosine monophosphate-protein kinase A (cAMP-PKA) on the expression of aquaporin 5 (AQP5) in ischemia/reperfusion (I/R) rats following deep hypothermia cardiac arrest. Wistar rats were randomly divided into: a sham control group (subjected to a sham operation); an I/R group (subjected to occlusion of the bronchial a.. Read More»

Genet. Mol. Res. 15(1): gmr.15017377

DOI: 10.4238/gmr.15017377

Comparative RNA profile analysis of idiopathic dilated cardiomyopathy and ischemic cardiomyopathy

Authors: L.L. Qiu, X.J. Ding, H.T. Zhu, L.W. Gao, J.F. Tang and X.Q. Liu

Previous research has focused on revealing the functions of each individual gene and/or pathway in idiopathic dilated cardiomyopathy (DCM) or ischemic cardiomyopathy (IC). However, the common or specific pathways of the initiation and processes of DCM and IC are still unclear. Here, we attempted to uncover the critical genes and potential molecular networ.. Read More»

Genet. Mol. Res. 15(1): gmr.15016910

DOI: 10.4238/gmr.15016910

Tumor necrosis factor-like weak inducer of apoptosis association with proliferative diabetic retinopathy and promotes proliferation and collagen synthesis in retinal ARPE-19 cells

Authors: D.Y. Chen and G.F. Su

Chronic inflammation develops in the retinal microvasculature under sustained hyperglycemia and is implicated in the pathogenesis of diabetic retinopathy. Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) and its receptor Fn14 have been reported to promote pro-inflammatory cytokines, which are involved in the pathogenesis of proliferative diabe.. Read More»

Genet. Mol. Res. 15(1): gmr.15016920

DOI: 10.4238/gmr.15016920

Role of single nucleotide polymorphisms of DNA repair genes in susceptibility to pancreatic cancer in Chinese population

Authors: M.F. Ying and R. Zhao

We conducted a case-control study to investigate the role of ERCC1-ERCC5 gene polymorphisms in the risk of pancreatic cancer. This study included 195 patients who were newly diagnosed with histopathologically confirmed primary pancreatic cancer, and 254 controls were recruited from Sir Run Run Shaw Hospital, between January 2012 and December 2014. Genotyp.. Read More»

Genet. Mol. Res. 15(1): gmr.15017273

DOI: 10.4238/gmr.15017273