Table of Contents | Genet. Mol. Res.2016(1)
Association between interleukin 17A gene polymorphisms and risk of coronary artery disease
Authors: X.S. Zheng1, S. Wang2 and M. Ni3
Coronary artery disease (CAD) represents a leading cause of morbidity and mortality worldwide, and genetic factors contribute to the development of this disease. We conducted a case-control study to assess the association between interleukin 17A (IL17A) rs2275913 and rs3748067 polymorphisms and development of CAD. A total of 372 CAD patients and 372 healt.. Read More»
Genet. Mol. Res. 15(1): gmr.15017074
DOI: 10.4238/gmr.15017074
PI3K, AKT, and P-AKT levels in thin endometrium
Authors: A.W. Le1, L.L. Shan1, X.Y. Dai1, T.H. Xiao1, X.R. Li1, Z.H. Wang1, J. Zhang2 and X.Y. Chen3
The aim of this study was to explore the expression of PI3K, AKT, and P-AKT, and to investigate the role of PI3K/AKT signaling pathway in thin endometrium. We included 40 women treated in affiliated Shenzhen Nanshan People’s Hospital of Guangdong Medical University for endometrial conditions between August 2013 and January 2015, 20 with a normal end.. Read More»
Genet. Mol. Res. 15(1): gmr.15017184
DOI: 10.4238/gmr.15017184
Y-STR genetic screening by high-resolution melting analysis
Authors: J.Q. Deng1*, B.Q. Liu2*, Y. Wang3, W. Liu4, J.F. Cai5, R. Long1 and W.H. Li1
Currently, the widely used automated capillary electrophoresis-based short tandem repeat (STR) genotyping method for genetic screening in forensic practice is laborious, time-consuming, expensive, and technically challenging in some cases. Thus, new molecular-based strategies for conclusively identifying forensically relevant biological evidence are requi.. Read More»
Genet. Mol. Res. 15(1): gmr.1501726605/02/2016
DOI: 10.4238/gmr.1501726605/02/2016
Bayesian approach increases accuracy when selecting cowpea genotypes with high adaptability and phenotypic stability
Authors: L.M.A. Barroso1*, P.E. Teodoro2*, M. Nascimento1, F.E. Torres2, A. dos Santos3, A.M. Corr�ªa2, E. Sagrilo4, C.C.G. Corr�ªa2, F.A. Silva2 and G. Ceccon5
This study aimed to verify that a Bayesian approach could be used for the selection of upright cowpea genotypes with high adaptability and phenotypic stability, and the study also evaluated the efficiency of using informative and minimally informative a priori distributions. Six trials were conducted in randomized blocks, and the grain yield of 17 upright.. Read More»
Genet. Mol. Res. 15(1): gmr.15017625
DOI: 10.4238/gmr.15017625
Tetrandrine induces microRNA differential expression in human hypertrophic scar fibroblasts in vitro
Authors: Tetrandrine induces microRNA differential expression in human hypertrophic scar fibroblasts in vitro
MicroRNAs (miRNAs) have recently been shown to play a role in normal wound healing process. miRNAs may be linked to pathologic wound healing and closely related to the formation of hypertrophic scars. This study aimed to explore the effects of tetrandrine on the miRNA expression profile in human hypertrophic scar fibroblasts (HSFs) in vitro. HSFs were ran.. Read More»
Genet. Mol. Res. 15(1): gmr.15017288
DOI: 10.4238/gmr.15017288
Selection and validation of reference houseÃ?Âkeeping genes in the J774A1 macrophage cell line for quantitative real-time PCR
Authors: F.B. Ferraz and J.H. Fernandez
Macrophages are essential components of the innate and adaptive immune responses, playing a decisive role in atherosclerosis, asthma, obesity, and cancer. The differential gene expression resulting from adhesion of macrophages to the extra-cellular matrix (ECM) has been studied in the J774A1 murine macrophage cell line using quantitative polymerase chain .. Read More»
Genet. Mol. Res. 15(1): gmr.15017720
DOI: 10.4238/gmr.15017720
Analysis of POU1F1 gene DdeI polymorphism in Chinese goats
Authors: M.J. Li1,2, C.M. Zhang2, X.Y. Lan1, X.T. Fang3, C.Z. Lei1 and H. Chen1
As a member of the POU-domain family, the POU1F1 is a positive regulator for growth hormone, prolactin and thyroid-stimulating hormone b, by binding to target DNA promoters as a dimer in mammals. This study described the polymorphisms at the goat POU1F1-DdeI locus and analyzed the distribution of alleles in 15 indigenous Chinese goat breeds. The PCR-RFLP .. Read More»
Genet. Mol. Res. 15(1): gmr.15017747
DOI: 10.4238/gmr.15017747
Docetaxel enhances apoptosis and G2/M cell cycle arrest by suppressing mitogen-activated protein kinase signaling in human renal clear cell carcinoma
Authors: T.D. Han, D.H. Shang and Y. Tian
Tremendous efforts have been made in renal cell carcinoma (RCC) patients’ research; however, clinical findings in patients have been disappointing. The aims of our study were to identify better or alternative therapeutic methods that can reverse chemotherapy resistance and to enhance sensitivity to docetaxel (DOX)-based chemotherapy drugs. We evalua.. Read More»
Genet. Mol. Res. 15(1): gmr.15017321
DOI: 10.4238/gmr.15017321