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Publications of : Z.H. Zhang
Human Genetics   Research Article

Clinical significance and expression of PUMA, MCL-1, and p53 in human renal cell carcinoma and para-carcinoma tissues

We investigated the expression level of p53 upregulated modulator of apoptosis (PUMA), myeloid cell leukemia-I (MCL-1), and p53 in renal cell carcinoma (RCC) and para-carcinoma tissues, as well as their clinical significance. The expression levels of PUMA, MCL-1, and p53 in RCC and para-carcinoma tissues were measured using immunohistochemical and quantitative real-.. Read More»

Genet. Mol. Res. 16(3): gmr16039278

DOI: 10.4238/gmr16039278

Animal Genetics   Research Article

Changes in cyclic GMP level and phosphodiesterase activity during follicular development in the rat ovary

    C.Q. Fu, F.X. Shi, Z.H. Zhang, J.R. Li, X.H. Huang and Z.C. Wang

Guanosine 3',5'-cyclic monophosphate (cGMP), as a second messenger, plays potential roles in ovarian functions. To elucidate the role of phosphodiesterase (PDE) in cGMP signaling during ovarian follicular development, the present study was conducted to investigate ovarian cGMP level and cGMP-PDE activity by radioimmunoassay (RIA) in postnatal rats, immature rats dur.. Read More»

Genet. Mol. Res. 13(3): 2014.August.7.7

DOI: 10.4238/2014.August.7.7

Human Genetics   Research Article

Temporal and spatial expression profiles of Frizzled 3 in the ovary during the estrous cycle

    S.B. Wang1,2,3, Y.P. Liu1,2, Z.H. Zhang2, Z.K. Wang2,3, Y.X. Xu3 and Z.C. Wang1,2,3

Frizzled 3 is an important receptor in the Wnt/β-catenin pathway, a conserved signaling pathway that regulates gene expression and controls diverse developmental processes. However, the role of this protein during follicular development in the adult ovary is not known. The present study was designed to investigate the expression and localization of Frizzled 3 mRNA and protein during the es.. Read More»

Genet. Mol. Res. 15(1): gmr.15017152

DOI: 10.4238/gmr.15017152

Animal Genetics   Research Article

Establishment of reference sequences of hepatitis B virus genotype C subgenotypes

    H.L. Zhu, C.T. Wang, J.B. Xia, X. Li and Z.H. Zhang

Hepatitis B virus genotype C (HBV/C) has the largest number of subgenotypes (C1-C16) that vary with geography and isolates. HBV/C prevails in Southeast Asia (C1, C5-C16), East Asia (C2), Oceania (C3), and Australia (C4). Suitable reference strains for different subgenotypes could greatly facilitate research into HBV/C, but unfortunately they are scarce. We retrieved 974 HBV/C full-length sequen.. Read More»

Genet. Mol. Res. 14(4): 2015

DOI: 10.4238/2015

Animal Genetics   Research Article

Expression of hypoxia-inducible factor-1α during ovarian follicular growth and development in Sprague-Dawley rats

    Z.H. Zhang, L.Y. Chen, F. Wang, Y.Q. Wu, J.Q. Su, X.H. Huang, Y. Cheng and Z.C. Wang

Hypoxia-inducible factor-1α (HIF-1α) has been identified as a transcription factor that is involved in diverse physiological and pathological processes in the ovary. In this study, we examined whether HIF-1α is expressed in a cell- and stage-specific manner during follicular growth and development in the mammalian ovaries. Using immunohistochemistry and Western blot analysis, .. Read More»

Genet. Mol. Res. 14(2): 2015.June.1.7

DOI: 10.4238/2015.June.1.7

Medical Genetics   Research Article

Clinical observational study of conformal radiotherapy combined with topotecan chemotherapy in patients with platinum-resistant recurrent ovarian cancer

    P. Wei,Z.H. Zhang,L. Li,X.L. Du,C.P. Shan and X.G. Sheng

This retrospective study aimed to observe the curative effect and adverse reactions of three-dimensional conformal radiotherapy combined with topotecan chemotherapy in patients with platinum-resistant recurrent epithelial ovarian carcinoma. The chemoradiotherapy group (N = 22) received 15 mv X-rays with 1.8 to 2.0 Gy/f/d radiation, 5 times per week. The total dose was 45 to 65 Gy; the median do.. Read More»

Genet. Mol. Res. 14(2):


Medical Genetics   Research Article

Catheter-directed thrombolysis in the treatment of acute deep venous thrombosis: a meta-analysis

    J.J. Zheng, Z.H. Zhang, Z. Shan, W.J. Wang, X.X. Li, S.M. Wang, Y.-X. Li and G.-S. Cheng

We performed a meta-analysis for systematic evaluation of the status quo of catheter thrombolysis for the treatment of acute lower limb deep vein thrombosis in China. We searched the China Biomedical bibliographic database (CBM), China National Knowledge Infrastructure (CNKI), Weipu full-text electronic journals, Wanfang full-text database, and Medline (1990 through.. Read More»

Genet. Mol. Res. 13(3): 2014.July.24.1

DOI: 10.4238/2014.July.24.1

Animal Genetics   Research Article

Identification and characterization of polymorphic microsatellite loci in the red-crowned crane

    L. Zhang, Z.H. Zhang, F.J. Shen, R. Hou, W.P. Zhang, Y.L. Liu, K.Y. Tu and A.L. Yang

We isolated and characterized microsatellite loci for the red-crowned crane (Grus japonensis) from a microsatellite-enriched database, which was obtained using high-throughput sequencing technology. We designed primer sets for 445 microsatellite loci and after initial screening, 34 loci were genotyped in 31 red-crowned cranes. The number of observed alleles ranged f.. Read More»

Genet. Mol. Res. 14(4): 2015.November.25.5

DOI: 10.4238/2015.November.25.5

Human Genetics   Research Article

Effects of HIF prolyl-hydroxylase-2 gene silencing on HCG-induced vascular endothelial growth factor expression in luteal cells

    Z.H. Zhang, D.Z. Yin, X.S Pang and Z.C. Wang

Vascular endothelial growth factor (VEGF)-dependent angiogenesis plays a crucial role in corpus luteum formation and its functional maintenance in mammalian ovaries. We recently reported that activation of hypoxia-inducible factor (HIF)-1α signaling contributes to the regulation of VEGF expression in luteal cells (LCs) in response to human chorionic gonadotropin (HCG). We examined whether.. Read More»

Genet. Mol. Res. 14(4): 2015.December.14.2

DOI: 10.4238/2015.December.14.2

Medical Genetics   Research Article

Effect of HIF-1a/VEGF signaling pathway on plasma progesterone and ovarian prostaglandin F2a secretion during luteal development of pseudopregnant rats

    X.Y. Pan, Z.H. Zhang, L.X. Wu and Z.C. Wang

The corpus luteum is a temporary endocrine structure in mammals that plays an important role in the female reproductive cycle and is formed from a ruptured and ovulated follicle with rapid angiogenesis. Vascular endothelial growth factor (VEGF) is thought to be vital in normal and abnormal angiogenesis in the ovary, but the molecular regulation of luteal VEGF expression during corpus luteum dev.. Read More»

Genet. Mol. Res. 14(3): 2015.August.3.3

DOI: 10.4238/2015.August.3.3

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