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Publications of : L. Su
Human Genetics   Research Article

Clinical significance and expression of PUMA, MCL-1, and p53 in human renal cell carcinoma and para-carcinoma tissues

We investigated the expression level of p53 upregulated modulator of apoptosis (PUMA), myeloid cell leukemia-I (MCL-1), and p53 in renal cell carcinoma (RCC) and para-carcinoma tissues, as well as their clinical significance. The expression levels of PUMA, MCL-1, and p53 in RCC and para-carcinoma tissues were measured using immunohistochemical and quantitative real-.. Read More»

Genet. Mol. Res. 16(3): gmr16039278

DOI: 10.4238/gmr16039278

Human Genetics   Research Article

Hypoxia facilitates epithelial-mesenchymal transition-mediated rectal cancer progress

    L.L. Sun, Z. Song, W.Z. Li and S.Y. Tang

Rectal cancer is a commonly observed tumor in clinics, and epithelial-mesenchymal transition (EMT) is very important for tumor invasion and metastasis. We established a rectal cancer HCT-116 cell hypoxia model and detected cell proliferation, invasion, and EMT-related protein expression in this model, aiming to analyze the effect of hypoxia on rectal cancer cell EMT.. Read More»

Genet. Mol. Res. 15(4): gmr15048936

DOI: 10.4238/gmr15048936

Human Genetics   Research Article

Expression of toll-like receptors in hepatic cirrhosis and hepatocellular carcinoma

    L. Sun, J.J. Dai1, W.F. Hu and J. Wang

Toll-like receptors (TLRs) can specifically identify pathogen-associated molecular patterns (PAMPs) by recognizing structural patterns in diverse microbial molecules, and can provide an effective defense against multiple microbial infectious. A variety of TLRs can be expressed on the surface of liver parenchymal as well as nonparenchymal cells. Kupffer cells are a type of hepatic nonparenchymal.. Read More»

Genet. Mol. Res. 15(2): gmr.15027419

DOI: 10.4238/gmr.15027419

Human Genetics   Research Article

A new method to induce myasthenia gravis models and the protective effect of soluble decay accelerating factors

    L. Sun, L. Xing, G.H. Zhang and S.Y. Pan

It is expensive to induce experimental autoimmune myasthenia gravis (EAMG) by active immunity, and difficult to obtain natural acetylcholine receptor (AChR). We sought a new method of inducing EAMG by immunizing rats with artificially synthesized AChR. The AChR mRNA in TE671 cells was extracted and reverse transcribed. The inclusion body was purified and protein concentration was determined, an.. Read More»

Genet. Mol. Res. 14(3): 2015.July.14.4

DOI: 10.4238/2015.July.14.4

Plant Genetics   Research Article

Optimization of a biolistic transformation system for transfer of antifreeze gene KN2 and the bar herbicide resistance gene in common wheat

    L. Cai, D.F. Sun and G.L. Sun

We studied the effects of different media for callus induction and differentiation, and pre-culture period of immature wheat embryo culture on biolistic transformation efficiency for including antifreeze gene KN2 and bar conferring resistance to the herbicide bialaphos. The percentage of plantlets generated from induction and differentiation media without Cu2+ was l.. Read More»

Genet. Mol. Res. 13(2):


Human Genetics   Research Article

Association of CYP1A1 MspI polymorphism with oral cancer risk in Asian populations: a meta-analysis

    J.L. Xu, R. Xia, L. Sun, X. Min, Z.H. Sun, C. Liu, H. Zhang and Y.M. Zhu

Numerous studies regarding the association between the CYP1A1 MspI polymorphism and oral cancer risk in Asian populations have shown controversial results. To get a more precise estimation of this relationship, we conducted a comprehensive meta-analysis. PubMed, the Cochrane Library, Elsevier Science Direct, Web of Knowledge, the Chinese National Knowledge Infrastru.. Read More»

Genet. Mol. Res. 15(2): gmr.15027688

DOI: 10.4238/gmr.15027688

Medical Genetics   Research Article

Pivotal role of microRNA-9 in osteosarcoma tumorigenesis and tumor progression

    X.J. Qi, J.F. Wang, G.D. Wang, Q. Xu and H.L. Sun

MicroRNA-9 (miR-9) has a well-established role in various tumors; the clinical significance and potential mechanism of miR-9 in human osteosarcoma (OS) has not been elucidated. The aim of this study was to investigate the mechanism and role of miR-9 expression in osteosarcoma cells. miR-9 expression in the OS cell line MG-63 and OS tissues was compared to that in a human osteoblastic cell line .. Read More»

Genet. Mol. Res. 15(1): gmr.15017318

DOI: 10.4238/gmr.15017318

Human Genetics   Research Article

Association between peroxisome proliferator-activated receptor gamma coactivator-1 alpha polymorphism and hypertension in Mongolians in Inner Mongolia

    X.L. Su, H.R. Dong, M.R. Yan, H.W. Cui, L. Yang and F.Q. Han

We investigated a possible association of peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α) Gly482Ser polymorphism with hypertension in Mongolians in Inner Mongolia. A total of 787 subjects were enrolled randomly, including 390 hypertension patients and 397 healthy controls. Triglycerides, cholesterol, and fasting plasma glucose wer.. Read More»

Genet. Mol. Res. 10(4): 2011.December.12.2

DOI: 10.4238/2011.December.12.2

Human Genetics   Research Article

Genetic polymorphisms of cytochrome P450 enzymes 2C9 and 2C19 in a healthy Mongolian population in China

    Z.F. Yang, H.W. Cui, T. Hasi, S.Q. Jia, M.L. Gong and X.L. Su

We examined the distribution of major allelic variants of CYP2C9 and CYP2C19 in the Mongolian population of China and compared it with that of other populations. The polymorphisms of CYP2C9 (including the CYP2C9*1, CYP2C9*2 and CYP2C9*3 alleles) and CYP2C19 (including the CYP2C19*1, CYP2C19*2 and CYP2C19*3 alleles) were analyzed in 280 healthy unrelated Chinese Mong.. Read More»

Genet. Mol. Res. 9(3): vol9-3gmr938

DOI: 10.4238/vol9-3gmr938

Human Genetics   Research Article

CCDC26 rs4295627 polymorphism (8q24.21) and glioma risk: a meta-analysis

    H.W. Lu, M. Huang, J.H. Wang, X.L. Sun and Y.Q. Ke

The association between the CCDC26 rs4295627 single nucleotide polymorphism (SNP) and the glioma risk has been studied previously, but these studies have yielded conflicting results. The aim of the present study is to analyze this association more vigorously, by means of a meta-analysis. A comprehensive literature search was performed in databases PubMed and EMBASE... Read More»

Genet. Mol. Res. 14(4): 2015.October.5.20

DOI: 10.4238/2015.October.5.20

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