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Publications of : X.L. Su
Human Genetics   Research Article

Clinical significance and expression of PUMA, MCL-1, and p53 in human renal cell carcinoma and para-carcinoma tissues

We investigated the expression level of p53 upregulated modulator of apoptosis (PUMA), myeloid cell leukemia-I (MCL-1), and p53 in renal cell carcinoma (RCC) and para-carcinoma tissues, as well as their clinical significance. The expression levels of PUMA, MCL-1, and p53 in RCC and para-carcinoma tissues were measured using immunohistochemical and quantitative real-.. Read More»

Genet. Mol. Res. 16(3): gmr16039278

DOI: 10.4238/gmr16039278

Human Genetics   Research Article

Association between peroxisome proliferator-activated receptor gamma coactivator-1 alpha polymorphism and hypertension in Mongolians in Inner Mongolia

    X.L. Su, H.R. Dong, M.R. Yan, H.W. Cui, L. Yang and F.Q. Han

We investigated a possible association of peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α) Gly482Ser polymorphism with hypertension in Mongolians in Inner Mongolia. A total of 787 subjects were enrolled randomly, including 390 hypertension patients and 397 healthy controls. Triglycerides, cholesterol, and fasting plasma glucose wer.. Read More»

Genet. Mol. Res. 10(4): 2011.December.12.2

DOI: 10.4238/2011.December.12.2

Human Genetics   Research Article

Genetic polymorphisms of cytochrome P450 enzymes 2C9 and 2C19 in a healthy Mongolian population in China

    Z.F. Yang, H.W. Cui, T. Hasi, S.Q. Jia, M.L. Gong and X.L. Su

We examined the distribution of major allelic variants of CYP2C9 and CYP2C19 in the Mongolian population of China and compared it with that of other populations. The polymorphisms of CYP2C9 (including the CYP2C9*1, CYP2C9*2 and CYP2C9*3 alleles) and CYP2C19 (including the CYP2C19*1, CYP2C19*2 and CYP2C19*3 alleles) were analyzed in 280 healthy unrelated Chinese Mong.. Read More»

Genet. Mol. Res. 9(3): vol9-3gmr938

DOI: 10.4238/vol9-3gmr938

Human Genetics   Research Article

CCDC26 rs4295627 polymorphism (8q24.21) and glioma risk: a meta-analysis

    H.W. Lu, M. Huang, J.H. Wang, X.L. Sun and Y.Q. Ke

The association between the CCDC26 rs4295627 single nucleotide polymorphism (SNP) and the glioma risk has been studied previously, but these studies have yielded conflicting results. The aim of the present study is to analyze this association more vigorously, by means of a meta-analysis. A comprehensive literature search was performed in databases PubMed and EMBASE... Read More»

Genet. Mol. Res. 14(4): 2015.October.5.20

DOI: 10.4238/2015.October.5.20

Animal Genetics   Research Article

cDNA, genomic sequence cloning and overexpression of ribosomal protein gene L9 (rpL9) of the giant panda (Ailuropoda melanoleuca)

    W.R. Hou, Y.L. Hou, G.F. Wu, Y. Song, X.L. Su, B. Sun and J. Li

The ribosomal protein L9 (RPL9), a component of the large subunit of the ribosome, has an unusual structure, comprising two compact globular domains connected by an α-helix; it interacts with 23 S rRNA. To obtain information about rpL9 of Ailuropoda melanoleuca (the giant panda) we designed primers based on the known mammalian nucleotide sequence. RT-PCR and P.. Read More»

Genet. Mol. Res. 10(3): vol10-3gmr1159

DOI: 10.4238/vol10-3gmr1159

Animal Genetics   Research Article

Detection of Jaagsiekte sheep retrovirus in the peripheral blood during the pre-clinical period of ovine pulmonary adenomatosis

    Y. Liu, Y.F. Zhang, X.L. Sun and S.Y. Liu

The envelope protein (Env) of the Jaagsiekte sheep retrovirus (JSRV) is known to be a unique oncoprotein responsible for inducing ovine pulmonary adenocarcinoma (OPA). The objective of this study was to prepare a specific monoclonal antibody (mAb) against the JSRV Env protein using bioinformatic analysis. According to the structure and epitope prediction results of .. Read More»

Genet. Mol. Res. 15(3): gmr.15038521

DOI: 10.4238/gmr.15038521

Medical Genetics   Research Article

Association of variants in renal salt reabsorption-related gene SLC12A3 with essential hypertension in a Mongolian population

    J.Q. Liang, Y.G. Xi, C.Y. An and X.L. Su

Mounting evidence has implicated the SLC12A3 gene in essential hypertension. Here, we examined the potential associations of common variants of the SLC12A3 gene with blood pressure traits in Mongolians in China. Genomic DNA was extracted from 508 unrelated Mongolian patients with essential hypertension and 246 normotensive Mongolian subjects for genotyping. The genotype distributions of all sel.. Read More»

Genet. Mol. Res. 14(3): 2015.August.21.9

DOI: 10.4238/2015.August.21.9

Medical Genetics   Research Article

Association of a CYP4A11 polymorphism and hypertension in the Mongolian and Han populations of China

    J.Q. Liang, M.R. Yan, L. Yang, Q. Suyila, H.W. Cui and X.L. Su

Human cytochrome P450 4A11 (CYP4A11) plays a role in the regulation of blood pressure through the conversion of arachidonic acid into 20-hydroxyeicosatetraenoic acid (20-HETE). We therefore investigated the association between a CYP4A11 polymorphism (rs9333025) with hypertension in the Mongolian and Han ethnic groups. We studied 514 Mongolians in a pastoral area, in.. Read More»

Genet. Mol. Res. 13(1): 2014.January.21.20

DOI: 10.4238/2014.January.21.20

Animal Genetics   Research Article

Correlation between PPARg2 gene Pro12Ala polymorphism and cerebral infarction in an Inner Mongolian Han Chinese population

    X. Li, B.L. Zhang*, X.G. Zhang and X.L. Su

The variant of PPAR-g2 has been shown to promote the increase of carotid IMT in patients suffering from cerebral infarction and the Pro12Ala polymorphism in the peroxisome proliferator-activated receptorg2 (PPARg2) gene may be associated with cerebral infarction. However, due to the different genetic background, race, and regional variations of cerebral infarction p.. Read More»

Genet. Mol. Res. 15(2): gmr.15027332

DOI: 10.4238/gmr.15027332

Human Genetics   Research Article

Association between serum angiopoietin-2 concentration and clinicopathological parameters in patients with colorectal cancer

    Z.Q. Wang,X.L. Sun,H.L. Su,X.F. Liu,Y.J. Xuan,S.Q. Yu

We examined the expression of angiopoietin-2 in serum samples from patients diagnosed with colorectal cancer and healthy volunteers and investigated the feasibility of using angiopoietin-2 as a potential diagnostic colorectal cancer biomarker. Enzyme-linked immunosorbent assays were used to measure the levels of angiopoietin-2 in patients with colorectal cancer and .. Read More»

Genet. Mol. Res. 14(4): 2015.December.1.5

DOI: 10.4238/2015.December.1.5

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