Y. Valle

Assessment of the rs4340 ACE gene polymorphism in acute coronary syndrome in a Western Mexican population

• A.Valdez-Haro
• Y. Valle
• E. Valdes-Alvarado
• F. Casillas-Muñoz
• J.F. Muñoz-Valle
• G.L. Reynoso-Villalpando
• H.E. Flores-Salinas
• J.R. Padilla-Gutiérrez

Acute coronary syndrome (ACS) is considered one of the main causes of death worldwide. Contradictory findings concerning the impact of the angiotensin-converting enzyme (ACE) gene on cardiovascular diseases have been reported. Previous conclusions point out that the variability in results depends on ethnicity and genetic polymorphisms to determine the association of.. Read More»

Genet. Mol. Res. 16(3): gmr16039779

DOI: 10.4238/gmr16039779

CD40 functional gene polymorphisms and mRNA expression in rheumatoid arthritis patients from western Mexico

I.V. Román-Fernández, D.F. Ávila-Castillo, S. Cerpa-Cruz,S. Gutiérrez-Ureña, J. Hernández-Bello, J.R. Padilla-Gutiérrez, Y. Valle, M.G. Ramírez-Dueñas, A.L. Pereira-Suárez and J.F. Muñoz-Valle

The CD40 pathway is involved in the development and pathogenesis of autoimmune diseases, including rheumatoid arthritis (RA). Two single nucleotide polymorphisms (SNPs) in the CD40 gene, rs1883832 and rs4810485, are associated with susceptibility to inflammatory and autoimmune diseases and are thought to alter CD40 expression at the mRNA and protein level. This stud.. Read More»

Genet. Mol. Res. 15(4): gmr15048775

DOI: 10.4238/gmr15048775

Pedigree analysis of Mexican families with Fabry disease as a powerful tool for identification of heterozygous females

B.E. Gutiérrez-Amavizca, R. Orozco-Castellanos, J. R. Padilla-Gutiérrez, Y. Valle and L.E. Figuera

Fabry disease (FD) is an X-linked lysosomal storage disease caused by α-galactosidase A deficiency; in contrast to other X-linked diseases, heterozygous females can be as affected as men. The construction and analysis of a family pedigree is a powerful tool to aid clinicians in diagnosis, establishment of inheritance pattern, and early detection of potentially.. Read More»

Genet. Mol. Res. 13(3): 2014.August.28.19

DOI: 10.4238/2014.August.28.19

Significance of linkage disequilibrium heterogeneous patterns in the 21q22.3 region for mapping 21 trisomy individualsv

Y. Valle, J.R. Padilla-Gutiérrez, A. Quintero-Ramos, I.J. García-González and F. Rivas

Recombination patterns can be indirectly inferred by means of linkage disequilibrium (LD) estimates, since LD is negatively correlated with genetic distance. However, LD does not necessarily have absolute correspondence with genetic distance. We estimated LD at 5 loci located in the 21q22.3 region. These STRs (D21S1440, D21S168, D21S1260, D21S1446, and D21S1411) covered 8.81 Mb of the 21q22.3 r.. Read More»

Genet. Mol. Res. 12(3): 2013.August.8.2

DOI: 10.4238/2013.August.8.2

Frequency distribution of interleukin-10 haplotypes (-1082 A>G, -819 C>T, and-592 C>A) in a Mexican population

M. Vázquez-Villamar, C.A. Palafox-Sánchez, J. Hernández-Bello,J.F. Muñoz-Valle, Y. Valle, A. Cruz, A.I. Alatorre-Meza and E. Oregon-Romero

Interleukin 10 (IL-10) is an immunoregulatory cytokine with multiple roles in the immune system. Three single nucleotide polymorphisms at positions -1082 (A>G), -819 (C>T), and -592 (C>A) in the promoter region of the IL10 gene are believed to be associated with different inflammatory, infectious, and autoimmune diseases. These polymorphisms exhibit a stron.. Read More»

Genet. Mol. Res. 15(4): gmr15048411

DOI: 10.4238/gmr15048411

Genetic contribution of CYP2C9, CYP2C19, and APOE variants in acenocoumarol response

J.A. Nastasi-Catanese1, J.R. Padilla-Gutiérrez2, Y. Valle2, F. Ortega-Gutiérrez3, M.P. Gallegos-Arreola4 and L.E. Figuera5,6

Oral anticoagulants of the coumarin type have an inconveniently narrow therapeutic window, making their use difficult. In Mexico, genetic variables that participate in the heterogeneity of the therapeutic response remain poorly investigated. With the focus on warfarin, extensive pharmacogenomic studies have been performed, including those on the CYP450 family and APOE. The objective of this stu.. Read More»

Genet. Mol. Res. 12(4): 2013.October.10.7

DOI: 10.4238/2013.October.10.7

Association of the FTO gene SNP rs17817449 with body fat distribution in Mexican women

J.J. Zermeño-Rivera1, J.P. Astocondor-Pérez1, Y. Valle2, J.R. Padilla-Gutiérrez2, R. Orozco-Castellanos3,4, L.E. Figuera5,6 and B.E. Gutiérrez-Amavizca5,6

Polymorphisms in the FTO gene are associated with obesity, body mass index, hip circumference, and visceral and subcutaneous fat area. The objective of this study was to analyze the association of the FTO rs17817449 genetic variant (T>G polymorphism) with body fat distribution patterns in women. We included 65 women and 71 healthy subjects in this study. Anthropometric parameters were determ.. Read More»

Genet. Mol. Res. 13(4):