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Publications of : G. Cheng
Animal Genetics   Research Article

Association of CYP2C19*2 with hyperlipidemia in patients with the wild-type CYP2C9

Arachidonic acids are metabolized by cytochromes P450 (CYP450) to epoxyeicosatrienoic acids (EETs). EETs have many cardiovascular protective effects such as vasodilation, anti-hypertension, anti-inflammation, lipid-lowering effects, and favorable effects on glucose homeostasis. This study aimed to investigate whether gene polymorphism of cytochrome P450 CYP2C9 and C.. Read More»

Genet. Mol. Res. 16(3): gmr16039737

DOI: 10.4238/gmr16039737

Human Genetics   Research Article

Prognostic significance of long non-coding RNA MALAT-1 in various human carcinomas: a meta-analysis

    J. Wang1*, A.M. Xu1*, J.Y. Zhang1*, X.M. He2, Y.S. Pan1, G. Cheng1, C. Qin1,L.X. Hua1 and Z.J. Wang1

The long non-coding RNA MALAT-1 plays an important role in cancer prognosis. The present research aimed to elucidate its precise predictive value in various human carcinomas. A quantitative meta-analysis was performed by searching PubMed, Embase, Web of Science, and Cochrane Library (most recently, January 2015) databases, and extracting data from studies that investigated the association betwe.. Read More»

Genet. Mol. Res. 15(1): gmr.15017433

DOI: 10.4238/gmr.15017433

Cytogenomics   Research Article

Adenovirus-mediated interference of FABP4 regulates mRNA expression of ADIPOQ, LEP and LEPR in bovine adipocytes

    S. Wei L.S. Zan H.B. Wang G. Cheng M. Du Z. Jiang G.J. Hausman D.C. McFarland M.V. Dodson

Fatty acid binding protein 4 (FABP4) is an important adipocyte gene, with roles in fatty acid transport and fat deposition in animals as well as human metabolic syndrome. However, little is known about the functional regulation of FABP4 at the cellular level in bovine. We designed and selected an effective shRNA (small hairpin RNA) against bovine FABP4, constructed a corresponding adenovirus (A.. Read More»

Genet. Mol. Res. 12(1): 2013.January.4.21

DOI: 10.4238/2013.January.4.21

Plant Genetics   Research Article

Genomic survey and gene expression analysis of the VDAC gene family in rice

    X. Xu*, Y.P. Tan, G. Cheng, X.Q. Liu, C.J. Xia, F.Y. Luo,C.T. Wang

The voltage-dependent anion channel (VDAC), also known as a mitochondrial porin, plays an important role in the regulation of metabolic and energetic functions of mitochondria, as well as in mitochondria-mediated apoptosis. Cytoplasmic male sterility (CMS) is of major economic importance for commercial hybrid production and a research model for the interaction be&sh.. Read More»

Genet. Mol. Res. 14(4): 2015.December.1.20

DOI: 10.4238/2015.December.1.20

Medical Genetics   Research Article

Association of the g.19074G>A genetic variant in the osteoprotegerin gene with bone mineral density in Chinese postmenopausal women

    Y.D. Zhang, Z. Zhang, N.F. Zhou, W.T. Jia, X.G. Cheng and X.J. Wei

Primary osteoporosis is a common health problem in postmenopausal women. This study aimed to detect the association of the g.19074G>A genetic variant in the osteoprotegerin gene (OPG) with bone mineral density (BMD) and primary osteoporosis. The created restriction site-polymerase chain reaction method was used to investigate the g.19074G>A genetic va.. Read More»

Genet. Mol. Res. 13(3): 2014.August.28.9

DOI: 10.4238/2014.August.28.9

Animal Genetics   Research Article

New polymorphisms in the novel LYRM1 gene are associated with body measurement and meat quality traits in Qinchuan cattle

    Y.K. Li, Y.F. Huangpu, J.B. Gao, N. Yang, C.Z. Fu, H.B. Wang, G. Cheng and L.S. Zan

Body measurement and meat quality traits play important roles in the evaluation of productivity in cattle; they are influenced by genetic and environmental factors. Recent studies have shown that LYRM1 is a novel gene related to obesity and may influence fat deposition. We screened for new polymorphisms in the bovine LYRM1 gene and analyzed their association with bo.. Read More»

Genet. Mol. Res. 13(3): 2014.March.12.18

DOI: 10.4238/2014.March.12.18

Microbial Genetics   Research Article

Polymorphisms in the bovine CIDEC gene are associated with body measurement traits and meat quality traits in Qinchuan cattle

    C.G. Mei, L.S. Gui, C.Z. Fu, H.C. Wang, J.L. Wang, G. Cheng and L.S. Zan

Previous studies have shown that the cell death-inducing DFF45-like effector-C (CIDEC) gene is involved in lipid storage and energy metabolism, suggesting that it is a potential candidate gene that affects body measurement traits (BMTs) and meat quality traits (MQTs). The aim of this study was to identify polymorphisms of the bovine CIDEC gene and analyze their possible associations with BMTs a.. Read More»

Genet. Mol. Res. 14(3): 2015.August.7.10

DOI: 10.4238/2015.August.7.10

Animal Genetics   Research Article

SNPs at 3'-UTR of the bovine CDIPT gene associated with Qinchuan cattle meat quality traits

    C.Z. Fu H. Wang C.G. Mei J.L. Wang B.J. Jiang X.H Ma H.B. Wang G. Cheng L.S. Zan

As the most ancient member of the wheat gluten family, the γ-gliadin genes are suitable for phylogenetic analysis among wheat and related species. Species in the grass genus Dasypyrum have been widely used for wheat cross breeding. However, the genomic relationships among Dasypyrum species have been little studied. We isolated 22 novel γ-gliadin gene sequences, among which 10 are putatively func.. Read More»

Genet. Mol. Res. 12(1): 2013.March.13.6

DOI: 10.4238/2013.March.13.6

Human Genetics   Research Article

Identification of ANAPC13 gene polymorphisms associated with body measurement traits in Bos taurus

    B.J. Jiang X.L. Zhan C.Z. Fu H.B. Wang G. Cheng L.S. Zan

Body measurement traits, influenced by genes and environmental factors, play numerous important roles in the value assessment of productivity and economy. There has been some indication that ANAPC13 influences adult height. We used PCR-SSCP and DNA sequencing technology to identify polymorphisms in the ANAPC13 gene. A polymorphism in intron 1 (A > G at base 17) was identified and an addition.. Read More»

Genet. Mol. Res. 11(3): 2012.June.15.6

DOI: 10.4238/2012.June.15.6

Animal Genetics   Research Article

Expression analysis of Gli1 and Gli2 in different tissues and muscle-derived cells of Qinchuan cattle

    Y. Liu, H. Wang, G. Cheng B. Jiang and L. Zan

The Hedgehog (Hh) signaling pathway regulates the differentiation of many kinds of cells and plays a critical role in many embryonic and postnatal developmental processes. Gli1 and Gli2 are two transcription factors of the Hh signaling pathway. In this study, we used quantitative real-time polymerase chain reaction to detect the relative expression of Gli1 and Gli2 in 13 tissues from three two-.. Read More»

Genet. Mol. Res. 13(4):

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