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W. Fan

Publications of : W. Fan
Animal Genetics   Research Article

Association of CYP2C19*2 with hyperlipidemia in patients with the wild-type CYP2C9

Arachidonic acids are metabolized by cytochromes P450 (CYP450) to epoxyeicosatrienoic acids (EETs). EETs have many cardiovascular protective effects such as vasodilation, anti-hypertension, anti-inflammation, lipid-lowering effects, and favorable effects on glucose homeostasis. This study aimed to investigate whether gene polymorphism of cytochrome P450 CYP2C9 and C.. Read More»

Genet. Mol. Res. 16(3): gmr16039737

DOI: 10.4238/gmr16039737

Animal Genetics   Research Article

Effects of acrylonitrile on lymphocyte lipid rafts and RAS/RAF/MAPK/ERK signaling pathways

    X.J. Li, B. Li, J.S. Huang, J.M. Shi, P. Wang, W. Fan and Y.L. Zhou

Acrylonitrile (ACN) is a widely used chemical in the production of plastics, resins, nitriles, acrylic fibers, and synthetic rubber. Previous epidemiological investigations and animal studies have confirmed that ACN affects the lymphocytes and spleen. However, the immune toxicity mechanism is unknown. Lipid rafts are cell membrane structures that are rich in cholest.. Read More»

Genet. Mol. Res. 13(3): 2014.September.26.12

DOI: 10.4238/2014.September.26.12

Human Genetics   Research Article

NLRP3 rs35829419 polymorphism is associated with increased susceptibility to multiple diseases in humans

    Q. Zhang, H.W. Fan, J.Z. Zhang, Y.M. Wang and H.J. Xing

Using a meta-analysis framework, we investigated the association between the NLRP3 rs35829419 polymorphism and increased susceptibility to diverse diseases in humans. Relevant published studies were identified through a comprehensive and systematic electronic search, using the following scientific literature databases: Science Citation Index, the Cochrane Library, PubMed, Embase, CINAHL, Curren.. Read More»

Genet. Mol. Res. 14(4): 2015.October.29.17

DOI: 10.4238/2015.October.29.17

Animal Genetics   Research Article

Risk factors for damaged liver function after chemotherapy in hepatitis B virus carriers with non-Hodgkin lymphoma

    X. Li, X.W. Fan, W. Liu, L. Guo, Y. Li, X. Hu, X. Liang,X.P. Ma and S.E. Yang

The goal of this study was to investigate damaged liver function after chemotherapy in hepatitis B virus (HBV) carriers with non-Hodgkin lymphoma (NHL) and to evaluate risk factors associated with a high risk of damaged liver function. Clinical histories of 134 HBV carriers with NHL who were treated with chemotherapy were obtained and analyzed for the occurrence of damaged liver function and ot.. Read More»

Genet. Mol. Res. 14(1): http://dx.doi.org/2015.March.30.25

DOI: http://dx.doi.org/10.4238/2015.March.30.25

Medical Genetics   Research Article

Expression of multidrug resistance 1 and multidrug resistance-related protein 1 in C57BL/6 mice treated with benzene

    J.-S. Huang, M.-D. Zhao, J.-M. Shi, J.-H. Zhang, B. Li, W. Fan, Y.-L. Zhou

ATP-binding cassette super family (ABC) proteins are considered key to oncology and pharmacology studies. We examined the effect of benzene on ABC pump protein levels in C57BL/6 mouse bone marrow mononuclear cells. After a 2-week gavage (200 mg/kg, 5 days per week), the number of peripheral leukocytes, lymphocytes and basophils dropped significantly; there was also .. Read More»

Genet. Mol. Res. 12(4): 2013.November.22.11

DOI: 10.4238/2013.November.22.11

Animal Genetics   Research Article

Effects of acrylonitrile on the pathological morphology and apoptosis of neurons in rats

    C.Z. Li, L.A. Tse, Y.L. Zhou, W. Fan, M. Li, I.T.S. Yu and T.Y. Jin

This study aimed to evaluate the effects of acrylonitrile (ACN) on neuronal morphology and apoptosis in rats. An ACN solution was administered to Wistar rats by gavage at doses of 0, 5, 10, or 20 mg/kg, 5 days a week for 13 weeks. The morphology of neurons and the presence of apoptosis was examined by light and electron microscope, DNA electrophoresis, immunohistoch.. Read More»

Genet. Mol. Res. 13(3): 2014.July.29.7

DOI: 10.4238/2014.July.29.7

Plant Genetics   Research Article

Crossbreeding of Phyllostachys species (Poaceae) and identification of their hybrids using ISSR markers

    X.C. Lin, Y.F. Lou, J. Liu, J.S. Peng, G.L. Liao and W. Fang

Crossbreeding is an efficient means to increase production and quality in plants; however, hybridization is seldom reported in bamboo. We crossbred two bamboo species Phyllostachys kwangsiensis (female parent) and Phyllostachys bambusoides (male parent) for the first time, and obtained suspected bamboo hybrids. We identified two bamboo hybrids from the above parents.. Read More»

Genet. Mol. Res. 9(3): vol9-3gmr855

DOI: 10.4238/vol9-3gmr855

Plant Genetics   Research Article

Identification of genes involved in spontaneous leaf color variation in Pseudosasa japonica

    H.Y. Yang, X.W. Xia, W. Fang, Y. Fu, M.M. An and M.B. Zhou

Spontaneous leaf color variation in bamboo provides the opportunity to study the mechanisms of leaf color formation and the breeding of ornamental bamboos. Despite the fact that many genes are known to be involved in leaf color variation in model plants, molecular mechanisms governing natural leaf color variation in bamboo have remained obscure. This study aimed to .. Read More»

Genet. Mol. Res. 14(4): 2015.October.2.16

DOI: 10.4238/2015.October.2.16

Human Genetics   Research Article

Association of PS1 1/2, ACE I/D, and LRP C/T polymorphisms with Alzheimer�s disease in the Chinese population: a meta-analysis of case-control studies

    L. Yang, H.-H. Zhou, Y.-F. Ye, X.-W. Fan, Y.-J. Wang and Y. Meng

The objective of this study was to assess the associations of presenilin 1 (PS1) 1/2, angiotensin I-converting enzyme (ACE) insertion/deletion (I/D), and low-density lipoprotein receptor-related protein (LRP) C/T polymorphisms with the risk of Alzheimer’s disease (AD) in the Chinese population. PS1 1/2, ACE I/D, and LRP C/T, which are commonly investigated polymorphisms, were evaluated to.. Read More»

Genet. Mol. Res. 14(1): 2015.February.6.5

DOI: 10.4238/2015.February.6.5

Human Genetics   Research Article

Effect of atorvastatin on plasma NT-proBNP and inflammatory cytokine expression in patients with heart failure

    H.Y. Duan, D.M. Liu, P. Qian, S.L. Wang, L.J. Yan, J.T. Wu, H.T. Yang, X.W. Fan, Y.J. Chu

The aim of this study was to explore the effect of atorvastatin intervention on plasma N-terminal pro-B-type natriuretic peptide (NT-proBNP) and inflammatory cytokine levels in patients with heart failure (HF). One hundred and twenty-three HF patients were selected from our hospital and randomly divided into control (N = 61) and observation (N = 62) groups; the form.. Read More»

Genet. Mol. Res. 14(4): 2015.December.1.25

DOI: 10.4238/2015.December.1.25