I.R. Costa
Analysis of p53 gene polymorphism (codon 72) in symptomatic patients with atherosclerosis
Atherosclerosis is a multifactorial pathological disease that alters the morphology and function of arterial walls. The atheroma growth leads to vessel hardening and lumen narrowing, limiting the blood flow. The atheroma plaque can eventually break, expose highly thrombogenic material and lead to platelet activation and subsequent formation of a thrombus that may bl.. Read More»
Genet. Mol. Res. 16(3): gmr16039721
DOI: 10.4238/gmr16039721
Environmental variations drive polyploid evolution in neotropical Eugenia species (Myrtaceae)
Polyploidy is one of the most important mechanisms of speciation and diversification in plant evolution. Polyploidy results in genetic variation among individuals of the same species and even between populations, and may be responsible for differences in environmental tolerance between populations of the same species. This study determined chromosome numbers of Euge.. Read More»
Genet. Mol. Res. 15(4): gmr15048842
DOI: 10.4238/gmr15048842
GSTM1 and GSTT1 polymorphisms in endometriosis in women from Goiás, Brazil
Endometriosis is a gynecologic pathology with a high prevalence and unknown etiology. Therefore, an increasing number of studies has been undertaken to search for associations between endometriosis and alterations or polymorphisms in candidate genes, including glutathione S-transferase mu 1 (GSTM1) and glutathione S-transferase theta 1 (GSTT1). We analyzed the frequency of present/absent polymo.. Read More»
Genet. Mol. Res. 12(3): 2013.August.2.1
DOI: 10.4238/2013.August.2.1
Polymorphisms of GSTM1, GSTT1, and p53 in Goiânia, Goiás
Genetic polymorphisms are defined as changes within the DNA sequences of genes that have frequencies in the population higher than 1%. The glutathione S-transferases play an important role in the cellular detoxification systems involved in oxidative stress that can lead to accumulation of reactive oxygen species. Epidemiological studies have suggested that individuals with homozygous deletion o.. Read More»
Genet. Mol. Res. 14(4): 2015.December.21.4
DOI: 10.4238/2015.December.21.4
Analysis of the prevalence of polymorphisms in the glutathione S transferase gene (GST) in cataract patients from Goiânia
The aim of this study was to determine the prevalence of polymorphisms in the glutathione S-transferase genes GSTM1 and GSTT1 in patients with lens opacity (cataract). Peripheral blood samples were obtained from male and female patients (N = 23) with cataract. The GSTM1 and GSTT1 polymorphic regions were amplified by polymerase chain reaction, and the amplification products were electrophoresed.. Read More»
Genet. Mol. Res. 15(3): gmr.15038050
DOI: 10.4238/gmr.15038050
Polymorphisms of GSTM1 and GSTT1 genes in symptomatic atherosclerotic patients with hypertension and/or type 2 diabetes mellitus
Atherosclerosis is a chronic inflammatory condition and originates due to the accumulation of lipids in the innermost layer of the arteries. It is often related due to other underlying diseases, such as systemic arterial hypertension and type 2 diabetes mellitus, which may be the cause or may contribute to a worse prognosis of atherosclerosis. Such diseases also hav.. Read More»
Genet. Mol. Res. 16(4): gmr16039836
DOI: 10.4238/gmr16039836
RsaI polymorphism of the ERβ gene in women with endometriosis
We examined the frequency of RsaI polymorphism of the ERβ gene in 54 patients diagnosed with endometriosis and 46 controls. Peripheral blood was collected from women undergoing laparoscopy with a confirmed diagnosis of endometriosis. Polymorphisms of the ERβ gene and p53 were assessed by PCR and analyzed on 2% agarose gel stained with ethidium bromide. The.. Read More»
Genet. Mol. Res. 10(1): vol10-1gmr940
DOI: 10.4238/vol10-1gmr940
Polymorphism of the progesterone receptor gene associated with endometriosis in patients from Goiás, Brazil
We investigated a possible link between endometriosis and polymorphism of the progesterone receptor gene (PROGINS). The endometriosis group consisted of 54 patients with a diagnosis of endometriosis by laparoscopy, and the control group comprised 44 women without endometriosis. Genotypes for PROGINS polymorphisms (A1/A1, A1/A2 and A2/A2) were determined by polymeras.. Read More»
Genet. Mol. Res. 10(3): vol10-3gmr913
DOI: 10.4238/vol10-3gmr913
Infertility caused by an association between Arg72Pro polymorphism of the p53 gene and Glu298Asp of the eNOS gene in patients with endometriosis
Endometriosis is characterized by ectopic endometrial tissue and affects millions of women worldwide. The disease leads to various symptoms such as chronic pelvic pain and infertility and does not yet have a well-defined etiology. The pathology is similar to cancer, since endometrial cells are highly proliferative, invade tissues and may be associated with tumor sup.. Read More»
Genet. Mol. Res. 17(3): http://dx.doi.org/gmr18046
DOI: http://dx.doi.org/10.4238/gmr18046
GSTM1 polymorphism in patients with clinical manifestations of atherosclerosis
Atherosclerosis is characterized by lesions, called atheroma or atheromatous plaques, in the inner layer of blood vessels, which block the vascular lumen and weaken the underlying tunica media. Several modifiable and non-modifiable risk factors for the development of atherosclerosis exist. The modifiable risk factors include hypertension, smoking, obesity, high LDL .. Read More»
Genet. Mol. Res. 16(1): gmr16019101
DOI: 10.4238/gmr16019101
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