K.K.V.O. Moura
Infertility caused by an association between Arg72Pro polymorphism of the p53 gene and Glu298Asp of the eNOS gene in patients with endometriosis
Endometriosis is characterized by ectopic endometrial tissue and affects millions of women worldwide. The disease leads to various symptoms such as chronic pelvic pain and infertility and does not yet have a well-defined etiology. The pathology is similar to cancer, since endometrial cells are highly proliferative, invade tissues and may be associated with tumor sup.. Read More»
Genet. Mol. Res. 17(3): http://dx.doi.org/gmr18046
DOI: http://dx.doi.org/10.4238/gmr18046
Glutathione S-transferase M1 and T1 polymorphism in men with idiopathic infertility
Male infertility is a heterogeneous disorder, with various genetic and environmental factors that contribute to the impairment of spermatogenesis. Genetic causes are responsible for 60% of cases of idiopathic infertility. Polymorphisms of genes that encode detoxifying enzymes of phase II drug metabolism can modify their expression or function, affecting the biotransformation of t.. Read More»
Genet. Mol. Res. 8(3): vol8-3gmr642
DOI: 10.4238/vol8-3gmr642
Analysis of the GSTM1-null polymorphism in patients with pterygium from Goiânia, Goiás Brazil
The first reports about pterygium date back to Hippocrates, and this disease still threatens vision health around the world. Pterygium is a formation of fibrous tissue consisting of highly vascularized epithelial and subepithelial tissue that grows excessively and with an abnormal shape on the cornea. Many physical and biological factors are associated with the pathogenesis of pterygium, includ.. Read More»
Genet. Mol. Res. 14(2): 2015.June.9.3
DOI: 10.4238/2015.June.9.3
GSTM1 and GSTT1 polymorphisms in endometriosis in women from Goiás, Brazil
Endometriosis is a gynecologic pathology with a high prevalence and unknown etiology. Therefore, an increasing number of studies has been undertaken to search for associations between endometriosis and alterations or polymorphisms in candidate genes, including glutathione S-transferase mu 1 (GSTM1) and glutathione S-transferase theta 1 (GSTT1). We analyzed the frequency of present/absent polymo.. Read More»
Genet. Mol. Res. 12(3): 2013.August.2.1
DOI: 10.4238/2013.August.2.1
Polymorphisms of GSTM1, GSTT1, and p53 in Goiânia, Goiás
Genetic polymorphisms are defined as changes within the DNA sequences of genes that have frequencies in the population higher than 1%. The glutathione S-transferases play an important role in the cellular detoxification systems involved in oxidative stress that can lead to accumulation of reactive oxygen species. Epidemiological studies have suggested that individuals with homozygous deletion o.. Read More»
Genet. Mol. Res. 14(4): 2015.December.21.4
DOI: 10.4238/2015.December.21.4
Association between primary open angle glaucoma and genetic polymorphisms GSTM1/GSTT1 in patients from Goiânia Central-West Region of Brazil
In this study, we evaluated the genotype profile of GSTM1 and GSTT1 polymorphisms in patient carriers of primary open-angle glaucoma in the population of Goiânia, GO, Brazil. This case-control study included 100 Brazilian patients with glaucoma and 53 patients without glaucoma. Blood samples were genotyped for polymorphisms in GST genes using polymerase chain reaction-based methods. Polym.. Read More»
Genet. Mol. Res. 13(4):
Analysis of the prevalence of polymorphisms in the glutathione S transferase gene (GST) in cataract patients from Goiânia
The aim of this study was to determine the prevalence of polymorphisms in the glutathione S-transferase genes GSTM1 and GSTT1 in patients with lens opacity (cataract). Peripheral blood samples were obtained from male and female patients (N = 23) with cataract. The GSTM1 and GSTT1 polymorphic regions were amplified by polymerase chain reaction, and the amplification products were electrophoresed.. Read More»
Genet. Mol. Res. 15(3): gmr.15038050
DOI: 10.4238/gmr.15038050
Polymorphisms of GSTM1 and GSTT1 genes in symptomatic atherosclerotic patients with hypertension and/or type 2 diabetes mellitus
Atherosclerosis is a chronic inflammatory condition and originates due to the accumulation of lipids in the innermost layer of the arteries. It is often related due to other underlying diseases, such as systemic arterial hypertension and type 2 diabetes mellitus, which may be the cause or may contribute to a worse prognosis of atherosclerosis. Such diseases also hav.. Read More»
Genet. Mol. Res. 16(4): gmr16039836
DOI: 10.4238/gmr16039836
Association between CYP1A1m1 gene polymorphism and primary open-angle glaucoma
The CYP1A1 gene is related to the generation of secondary metabolites that are capable of inducing DNA damage. The CYP1A1m1 polymorphism has been examined in many studies, and is located in a region near loci that have been linked to glaucoma, including the locus GLC1I. As a result, this polymorphism has been related to several diseases that are influenced by exposure to xenobiotic as well as p.. Read More»
Genet. Mol. Res. 13(4): 2014.December.4.33
DOI: 10.4238/2014.December.4.33
Characterization of molecular hemoglobin c and beta thalassemia
The hemoglobinopathies are a group of hereditary alterations prevalent in many parts of the world, but significantly affect the Brazilian population for its abundant miscegenation. These alterations in structural genes that cause the formation of hemoglobin variants, and/or regulatory genes, causing thalassemias. Currently, the number of identified abnormal hemoglob.. Read More»
Genet. Mol. Res. 16(4): gmr16039851
DOI: 10.4238/gmr16039851
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