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Publications of : M.H. Lagares
Human Genetics   Research Article

Characterization of molecular hemoglobin c and beta thalassemia

The hemoglobinopathies are a group of hereditary alterations prevalent in many parts of the world, but significantly affect the Brazilian population for its abundant miscegenation. These alterations in structural genes that cause the formation of hemoglobin variants, and/or regulatory genes, causing thalassemias. Currently, the number of identified abnormal hemoglob.. Read More»

Genet. Mol. Res. 16(4): gmr16039851

DOI: 10.4238/gmr16039851

Human Genetics   Research Article

Polymorphisms of GSTM1 and GSTT1 genes in symptomatic atherosclerotic patients with hypertension and/or type 2 diabetes mellitus

Atherosclerosis is a chronic inflammatory condition and originates due to the accumulation of lipids in the innermost layer of the arteries. It is often related due to other underlying diseases, such as systemic arterial hypertension and type 2 diabetes mellitus, which may be the cause or may contribute to a worse prognosis of atherosclerosis. Such diseases also hav.. Read More»

Genet. Mol. Res. 16(4): gmr16039836

DOI: 10.4238/gmr16039836

Human Genetics   Research Article

GSTM1 polymorphism in patients with clinical manifestations of atherosclerosis

    D.A. Rodrigues, J.V.M. Martins, K.S.F. e Silva, I.R. Costa, M.H. Lagares, F.L. Campedelli, A.M. Barbosa, M.P. de Morais and K.K.V.O. Moura

Atherosclerosis is characterized by lesions, called atheroma or atheromatous plaques, in the inner layer of blood vessels, which block the vascular lumen and weaken the underlying tunica media. Several modifiable and non-modifiable risk factors for the development of atherosclerosis exist. The modifiable risk factors include hypertension, smoking, obesity, high LDL .. Read More»

Genet. Mol. Res. 16(1): gmr16019101

DOI: 10.4238/gmr16019101

Human Genetics   Research Article

Scientometric analysis: Five years of genetic polymorphisms

Scientometrics is a quantitative evaluation of scientific and technological activities. The main objective is to point the number of methodologies used in scientific studies or even the structure of several research centers. This type of metric study belongs to the area of sociology of scientific knowledge. It covers quantitative analyzes of scientific activities th.. Read More»

Genet. Mol. Res. 17(2): gmr16039913

DOI: 10.4238/gmr16039913

Human Genetics   Research Article

Atherosclerosis: analysis of the eNOS (T786C) gene polymorphism

The coronary arteriosclerotic disease is the most common cardiovascular disease. Atherosclerosis affects large- and medium-sized arteries leading to severe thrombosis or artery stenosis that could evolve to myocardial infarction, ischemic stroke, ischemic injury of kidneys and intestines, and several other life-threatening clinical manifestations. Nitric oxide has b.. Read More»

Genet. Mol. Res. 16(3): gmr16039708

DOI: 10.4238/gmr16039708

Human Genetics   Research Article

Analysis of p53 gene polymorphism (codon 72) in symptomatic patients with atherosclerosis

Atherosclerosis is a multifactorial pathological disease that alters the morphology and function of arterial walls. The atheroma growth leads to vessel hardening and lumen narrowing, limiting the blood flow. The atheroma plaque can eventually break, expose highly thrombogenic material and lead to platelet activation and subsequent formation of a thrombus that may bl.. Read More»

Genet. Mol. Res. 16(3): gmr16039721

DOI: 10.4238/gmr16039721

Human Genetics   Research Article

Polymorphism of the gene eNOS G894T (Glu298Asp) in symptomatic patients with aterosclerosis

Atherosclerotic and its cardiovascular complications are responsible for 17.5 million deaths a year, according to the World Health Organization. There is consensus that atherosclerosis involves multiple pathogenic processes initiated by endothelial dysfunction, with inflammation and vascular proliferation determining alterations in the matrix, with consequent format.. Read More»

Genet. Mol. Res. 16(2): gmr16029550

DOI: 10.4238/gmr16029550

Human Genetics   Research Article

Molecular analysis of the GSTT1 gene polymorphism in patients with clinical manifestation of atherosclerosis

Atherosclerosis is a chronic inflammatory disease formed by the accumulation of lipids in the innermost layer and large-caliber artery (tunica intima). This accumulation, along with platelet factors, stimulates the proliferation of muscle cells in this region. Over than 400 genes may be related to the pathology since they regulate endothelial function, coagulation, .. Read More»

Genet. Mol. Res. 16(3): gmr16039620

DOI: 10.4238/gmr16039620

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