J.V.M. Martins
Molecular analysis of the GSTT1 gene polymorphism in patients with clinical manifestation of atherosclerosis
Atherosclerosis is a chronic inflammatory disease formed by the accumulation of lipids in the innermost layer and large-caliber artery (tunica intima). This accumulation, along with platelet factors, stimulates the proliferation of muscle cells in this region. Over than 400 genes may be related to the pathology since they regulate endothelial function, coagulation, .. Read More»
Genet. Mol. Res. 16(3): gmr16039620
DOI: 10.4238/gmr16039620
Pterygium in patients from Goiânia, Goiás, Brazi
Pterygium is an inflammatory and degenerative ocular surface disease in which the conjunctiva on the cornea grows to form a fibrous tissue in the shape of a triangle. The disorder may be characterized by cell proliferation, inflammatory processes, fibrosis, angiogenesis, and destruction of the extracellular matrix. The anomaly is considered a degenerative eye disease and is erroneously confused.. Read More»
Genet. Mol. Res. 14(2): 2015.June.9.4
DOI: 10.4238/2015.June.9.4
Analysis of the GSTM1-null polymorphism in patients with pterygium from Goiânia, Goiás Brazil
The first reports about pterygium date back to Hippocrates, and this disease still threatens vision health around the world. Pterygium is a formation of fibrous tissue consisting of highly vascularized epithelial and subepithelial tissue that grows excessively and with an abnormal shape on the cornea. Many physical and biological factors are associated with the pathogenesis of pterygium, includ.. Read More»
Genet. Mol. Res. 14(2): 2015.June.9.3
DOI: 10.4238/2015.June.9.3
Polymorphisms of GSTM1, GSTT1, and p53 in Goiânia, Goiás
Genetic polymorphisms are defined as changes within the DNA sequences of genes that have frequencies in the population higher than 1%. The glutathione S-transferases play an important role in the cellular detoxification systems involved in oxidative stress that can lead to accumulation of reactive oxygen species. Epidemiological studies have suggested that individuals with homozygous deletion o.. Read More»
Genet. Mol. Res. 14(4): 2015.December.21.4
DOI: 10.4238/2015.December.21.4
Analysis of the prevalence of polymorphisms in the glutathione S transferase gene (GST) in cataract patients from Goiânia
The aim of this study was to determine the prevalence of polymorphisms in the glutathione S-transferase genes GSTM1 and GSTT1 in patients with lens opacity (cataract). Peripheral blood samples were obtained from male and female patients (N = 23) with cataract. The GSTM1 and GSTT1 polymorphic regions were amplified by polymerase chain reaction, and the amplification products were electrophoresed.. Read More»
Genet. Mol. Res. 15(3): gmr.15038050
DOI: 10.4238/gmr.15038050
Polymorphisms of GSTM1 and GSTT1 genes in symptomatic atherosclerotic patients with hypertension and/or type 2 diabetes mellitus
Atherosclerosis is a chronic inflammatory condition and originates due to the accumulation of lipids in the innermost layer of the arteries. It is often related due to other underlying diseases, such as systemic arterial hypertension and type 2 diabetes mellitus, which may be the cause or may contribute to a worse prognosis of atherosclerosis. Such diseases also hav.. Read More»
Genet. Mol. Res. 16(4): gmr16039836
DOI: 10.4238/gmr16039836
GSTM1 polymorphism in patients with clinical manifestations of atherosclerosis
Atherosclerosis is characterized by lesions, called atheroma or atheromatous plaques, in the inner layer of blood vessels, which block the vascular lumen and weaken the underlying tunica media. Several modifiable and non-modifiable risk factors for the development of atherosclerosis exist. The modifiable risk factors include hypertension, smoking, obesity, high LDL .. Read More»
Genet. Mol. Res. 16(1): gmr16019101
DOI: 10.4238/gmr16019101
Scientometric analysis: Five years of genetic polymorphisms
Scientometrics is a quantitative evaluation of scientific and technological activities. The main objective is to point the number of methodologies used in scientific studies or even the structure of several research centers. This type of metric study belongs to the area of sociology of scientific knowledge. It covers quantitative analyzes of scientific activities th.. Read More»
Genet. Mol. Res. 17(2): gmr16039913
DOI: 10.4238/gmr16039913
Atherosclerosis: analysis of the eNOS (T786C) gene polymorphism
The coronary arteriosclerotic disease is the most common cardiovascular disease. Atherosclerosis affects large- and medium-sized arteries leading to severe thrombosis or artery stenosis that could evolve to myocardial infarction, ischemic stroke, ischemic injury of kidneys and intestines, and several other life-threatening clinical manifestations. Nitric oxide has b.. Read More»
Genet. Mol. Res. 16(3): gmr16039708
DOI: 10.4238/gmr16039708
Analysis of p53 gene polymorphism (codon 72) in symptomatic patients with atherosclerosis
Atherosclerosis is a multifactorial pathological disease that alters the morphology and function of arterial walls. The atheroma growth leads to vessel hardening and lumen narrowing, limiting the blood flow. The atheroma plaque can eventually break, expose highly thrombogenic material and lead to platelet activation and subsequent formation of a thrombus that may bl.. Read More»
Genet. Mol. Res. 16(3): gmr16039721
DOI: 10.4238/gmr16039721
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