C.L. Liu
Mac-1 deficiency induces respiratory failure by affecting type I alveolar epithelial cells
As a β2 integrin family member, Mac-1 plays an important role in the inflammatory response. Inflammation and lung injury are closely associated, but the involvement of Mac-1 in the occurrence and development of such pathologies remains poorly understood. We aimed to investigate the relationship between Mac-1 deficiency and respiratory failure in Mac-1 knockout .. Read More»
Genet. Mol. Res. 16(3): gmr16039045
DOI: 10.4238/gmr16039045
P2X7 receptor in the hippocampus is involved in gp120-induced cognitive dysfunction
To investigate the role of the P2X7 receptor in learning and memory dysfunction induced by HIV-1 envelope glycoprotein gp120 (gp120), we established HIV-1-associated dementia (HAD) animal models by intracerebroventricular (ICV) infusion of gp120 in rats. We observed gp120-induced cognitive dysfunction in the radial arm water maze test. Results showed that rats in th.. Read More»
Genet. Mol. Res. 16(1): gmr16019356
DOI: 10.4238/gmr16019356
Molecular characterization, tissue distribution, and immune reaction expression of karyopherins in the domestic silkworm (Bombyx mori)
Karyopherins, including alpha and beta types, are transport proteins in the eukaryotic cell that carry cargoes across nuclear pore complexes into or out of the nucleus. In this study, full open reading frames of one beta and three alpha types of karyopherin were cloned from cDNA of the domestic silkworm (Bombyx mori). The one beta and three alpha types’ open reading frames were 2661, 1563.. Read More»
Genet. Mol. Res. 14(4): 2015.October.26.1
DOI: 10.4238/2015.October.26.1
Genomic structure, polymorphism and expression analysis of growth hormone-releasing hormone and pituitary adenylate cyclase activating polypeptide genes in the half-smooth tongue sole (Cynoglossus semilaevis)
Growth hormone-releasing hormone (GHRH) and pituitary adenylate cyclase activating polypeptide (PACAP) regulate development and somatic growth in teleosts; they may be associated with sexual growth dimorphism in the half-smooth tongue sole (Cynoglossus semilaevis). We found that the full-length GHRH and PACAP gene sequences obtained from females and males consist of.. Read More»
Genet. Mol. Res. 10(4): 2011.December.12.1
DOI: 10.4238/2011.December.12.1
Protective effects of naringin against gp120-induced injury mediated by P2X7 receptors in BV2 microglial cells
This study was aimed at exploring the effects of P2X7 receptors on gp120-induced injury and naringin’s protective effects against gp120-induced injury in BV2 microglia. BV2 microglia injury model was established by gp120 treatment and MTS assay was used to verify whether naringin has a cell-protective effect against gp120-induced injury. Changes in P2X7 recept.. Read More»
Genet. Mol. Res. 15(2): gmr.15028649
DOI: 10.4238/gmr.15028649
HuGE systematic review and meta-analysis demonstrate association of CASP-3 and CASP-7 genetic polymorphisms with cancer risk
Genetic variations in the caspase genes CASP-3 and CASP-7 are known to be involved in apoptosis, cytokine maturation, cell growth and differentiation. Polymorphisms of CASP-3 and CASP-7 genes have been increasingly recognized as important regulators in the development of cancer. However, whether there is a specific association is still controversial. Therefore, we made a Human Genome Epidemiolo.. Read More»
Genet. Mol. Res. 12(2): 2013.May.13.10
DOI: 10.4238/2013.May.13.10
Linkage and mapping analyses of the normal marking gene +P in the silkworm (Bombyx mori) using SSR markers
In the silkworm, Bombyx mori, normal markings are mainly controlled by the +P gene, which is located on the second chromosome. Due to a lack of crossing over in females, reciprocal backcrossed F1 (BC1) progenies were used for linkage analysis and mapping of the +P gene based on an SSR linkage map using silkworm strains P50 and H9, which are normal marking and sex-limited marking, respectively. .. Read More»
Genet. Mol. Res. 12(3): 2013.January.22.1
DOI: 10.4238/2013.January.22.1
Role of CASP-10 gene polymorphisms in cancer susceptibility: a HuGE review and meta-analysis
We investigated a possible association between CASP-10 gene polymorphisms and susceptibility to cancer through a meta-analysis. Eight studies with a total of 29,936 cancer cases and 34,041 healthy controls were included. Meta-analysis results showed that the rs13006529*T carrier was significantly associated with increased cancer risk (OR = 1.17, 95%CI = 1.01-1.36, P = 0.03). However, rs3900115 and.. Read More»
Genet. Mol. Res. 11(4): 2012.November.26.1
DOI: 10.4238/2012.November.26.1
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