Microbial Genetics
Identification and phylogenetic analysis of a sheep pox virus isolated from the Ningxia Hui Autonomous Region of China
Authors: X.L. Zhu, F. Yang, H.X. Li, Y.X. Dou, X.L. Meng, H. Li, X.N. Luo and X.P. Cai
An outbreak of sheep pox was investigated in the Ningxia Hui Autonomous Region in China. Through immunofluorescence testing, isolated viruses, polymerase chain reaction identification, and electron microscopic examination, the isolated strain was identified as a sheep pox virus. The virus was identified through sequence and phylogenetic analysis of the P3.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.May.14.7
- DOI:
- 10.4238/2013.May.14.7
Antimutagenic and anticarcinogenic effects of wheat bran in vivo
Authors: J.R. Pesarini, P.T. Zaninetti, M.O. Mauro, C.M. Carreira, J.B. Dichi, L.R. Ribeiro, M.S. Mantovani and R.J. Oliveira
Previous studies in rodents treated with the pro-carcinogen 1,2-dimethylhydrazine suggested that the consumption of wheat bran protected against DNA damage in the colon and rectum. Based on this information, we evaluated wheat bran as a functional food in the prevention and treatment of colon cancer. We used the aberrant crypt focus assay to evaluate the .. Read More»
- Genet. Mol. Res. 12(2):
- 2013.May.14.5
- DOI:
- 10.4238/2013.May.14.5
Overexpression of pucC improves the heterologous protein expression level in a Rhodobacter sphaeroides expression system
Authors: L. Cheng,G. Chen,G. Ding,Z. Zhao,T. Dong and Z. Hu
The Rhodobacter sphaeroides system has been used to express membrane proteins. However, its low yield has substantially limited its application. In order to promote the protein expression capability of this system, the pucC gene, which plays a crucial role in assembling the R. sphaeroides light-harvesting 2 complex (LH2), was overexpressed. To build a puc.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.27.21
- DOI:
- http://dx.doi.org/10.4238/2015.April.27.21
Downregulation of MACC1 expression enhances cisplatin sensitivity in SKOV-3/DDP cells
Authors: Z.M. Chen, H.R. Shi, X. Li, Y.X. Deng and R.T. Zhang
The aim of this study was to investigate the correlation between MACC1 expression and resistance to cisplatin (DDP) in DDP-resistant human epithelial ovarian cancer SKOV-3 cells (SKOV-3/DDP). MACC1 mRNA and protein expression levels in SKOV-3 and SKOV-3/DDP cells were detected by reverse transcriptase polymerase chain reaction and western blot. The SKOV-3.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.16.13
- DOI:
- 10.4238/2015.December.16.13
Regulation network of serum cytokines induced by tuberculosis-specific antigens reveals biomarkers for tuberculosis diagnosis
Authors: M. Wei, Z.Y. Wu, J.H. Lin, Y. Li, Z.X. Qian, Y.Q. Xie, H. Su and W. Zhou
In this study, we identified potential serum biomarkers for the diagnosis of active tuberculosis (TB) and screening for latent TB infections (LTBIs). Peripheral blood samples from 40 healthy individuals, 40 patients with TB, and 40 LTBI individuals were stimulated with the TB-specific antigens ESAT-6 and CFP-10. Human inflammatory cytokine arrays were use.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.16.18
- DOI:
- 10.4238/2015.December.16.18
Association of single nucleotide polymorphisms in the CYP1B1 gene with the risk of primary open-angle glaucoma: a meta-analysis
Authors: Z Wang, M. Li, L. Li, H. Sun and X.Y. Lin
Mutations in the CYP1B1 gene were detected in primary open-angle glaucoma (POAG) patients. However, the association between these mutations and the incidence of POAG remains to be elucidated. Here, we have conducted a meta-analysis to analyze this correlation, using relevant studies obtained from an extensive search of various electronic databases, includ.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.16.26
- DOI:
- 10.4238/2015.December.16.26
Expression of GRIN2A in benign and malignant nasopharyngeal diseases and its clinical significance
Authors: X.J. Zhou, B.R. Lin and Y. Wang
The gene glutamate receptor, ionotropic, N-methyl D-aspartate 2A (GRIN2A) is associated with development and neuron viability, and our previous studies showed it to be substantially methylated in nasopharyngeal carcinoma, indicating a link to this disease. The aim of this work was to investigate GRIN2A expression and its clinical significance in nasophary.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.16.29
- DOI:
- 10.4238/2015.December.16.29
Analysis of the beta-globin gene in DNA of suspected thalassemic great apes
Authors: J. Vuch, M.S. Siori, M.P. Bigatti, L. Segat, G. De Fabrizio and S. Crovella
DNA was recovered from teeth of 2 great ape skeletons, Pan troglodytes (Ptr) and Pongo pygmaeus (Ppy), belonging to a 19th-century zoological collection. The skeletons presented morphological alterations possibly associated with β-thalassemia: Ptr had deformation of the calvaria and oro-maxillo-facial bones with porotic hyperostosis and extend.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.May.21.4
- DOI:
- 10.4238/2013.May.21.4
Association between IL-1RN gene polymorphisms and susceptibility to ankylosing spondylitis: a large Human Genome Epidemiology review and meta-analysis
Authors: G.X. Jin, J.Z. Duan, W.L. Guo, L. Li, S.Q. Cui and H. Wang
We made a Human Genome Epidemiology review and meta-analysis to examine a possible association between interleukin-1 receptor antagonist (IL-1RN) polymorphisms and susceptibility to ankylosing spondylitis (AS). Studies of IL-1RN polymorphisms and susceptibility to AS were found by searching the Pubmed, Cochrane library, Embase, Web of Science, Springerlin.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.May.21.3
- DOI:
- 10.4238/2013.May.21.3
Influence of the XbaI polymorphism in the estrogen receptor-�± gene on human spermatogenic defects
Authors: J. Meng, X. Mu and Y.M. Wang
Polymorphisms of estrogen receptor (ER) genes have been implicated in male infertility, but studies of this association have produced conflicting results. The present study was conducted to examine whether polymorphisms within the ERα and ERβ genes are susceptibility factors for human male idiopathic infertility in Chinese men. We investigated .. Read More»
- Genet. Mol. Res. 12(2):
- 2013.June.11.1
- DOI:
- 10.4238/2013.June.11.1