Microbial Genetics
MicroRNA-26b inhibits osteosarcoma cell migration and invasion by down-regulating PFKFB3 expression
Authors: W.D. Zheng, F.L. Zhou and N. Lin
MicroRNAs regulate target gene expression and are involved in cell proliferation, apoptosis, differentiation, tumor invasion, and cancer stem cell regulation, among other processes. MicroRNA-26b (miR-26b) is closely related to tumor occurrence and development. In this study, we analyzed miR-26b expression in osteosarcoma tissue, its effect on Saos-2 osteo.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.14.14
- DOI:
- 10.4238/2015.December.14.14
An SduI polymorphism at intron 20 of the Chinese Holstein cow STAT4 gene and its effect on milk performance traits
Authors: X.M. Song, L. Zhang, J.F. Jiang, F.X. Shi and Y.Q. Jiang
The signal transducer and activator of transcription (STAT) genes are responsive to a wide range of cytokines, growth factors, and hormones, and thus control important biological processes. In humans, STAT4 mutations have been identified as genetic markers for rheumatoid arthritis, systemic lupus erythematosus, and primary Sjögren’s syndrome, w.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.May.13.13
- DOI:
- 10.4238/2013.May.13.13
Molecular characterization of carbapenemase genes in Acinetobacter baumannii in China
Authors: F. Fang, S. Wang, Y.X. Dang, X. Wang and G.Q. Yu
Acinetobacter baumannii is an aerobic non-motile Gram-negative coccobacillus, and it is one of the most important nosocomial pathogens worldwide. The aim of this study was to determine the molecular epidemiology of the outbreak strains. Between March 2011 and March 2014, a total of 205 strains of A. baumannii were isolated from patients at the Nanyang Cit.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017432
- DOI:
- 10.4238/gmr.15017432
Molecular cloning of the perilipin gene and its association with carcass and fat traits in Chinese ducks
Authors: H.L. Zhang, H.J. Fan, X.L. Liu, Y. Wu and S.S. Hou
The perilipin (PLIN) gene is a candidate gene of carcass and fat traits in ducks. In order to study the molecular character of the PLIN gene and its function in different breeds of Chinese ducks, samples were obtained from the Chinese Academy of Agricultural Sciences Research Center for Birds, including 95 Peking ducks of the Z2 series, 91 Peking ducks of.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.May.13.12
- DOI:
- 10.4238/2013.May.13.12
Diversity and structure of a bacterial community in grassland soils disturbed by sheep grazing, in the Loess Plateau of northwestern China
Authors: Y.N. Gou, Z.B. Nan and F.J. Hou
The relationship between disturbance, biodiversity, and ecosystem function has been a hot topic recently in international ecological research, and a universally applicable model remains elusive. In this study, we assessed the diversity and structure of a bacterial community in grassland soils along a disturbance gradient due to sheep grazing. Bacteria wer.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.15.5
- DOI:
- 10.4238/2015.December.15.5
Deep sequencing-based analysis of gene expression in bovine mammary epithelial cells after Staphylococcus aureus, Escherichia coli, and Klebsiella pneumoniae infection
Authors: L. Xiu, Y.B. Fu, Y. Deng, X.J. Shi, Z.Y. Bian, A. Ruhan and X. Wang
The goal of this study was to characterize the transcriptome of primary bovine mammalian epithelial cells (pBMECs) and to identify candidate genes for response and resistance to Staphylococcus aureus (strain S108), Escherichia coli (strain E23), and Klebsiella pneumoniae (strain K96) infection. Using Solexa sequencing, approximately 4.9 million total sequ.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.15.1
- DOI:
- 10.4238/2015.December.15.1
Investigation of polymorphisms in anti-inflammatory cytokine genes in hematogenous osteomyelitis
Authors: A.E. Osman, M. Mubasher, N.E. ElSheikh, H. AlHarthi, I.A. AlAlallah, A.A. Elbeshir, M. Abashar, N. Elsidig, G. ElGhazali and A.-S.A. Fadil
Osteomyelitis is a progressive bone infection disease caused by destructive immunological inflammatory reactions following new bone formation. Anti-inflammatory cytokines are a series of immunoregulatory molecules that control the pro-inflammatory cytokine response. In this study, we investigated 9 single nucleotide polymorphisms in 5 different cytokine/c.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.15.4
- DOI:
- 10.4238/2015.December.15.4
Lactic acid bacteria protect human intestinal epithelial cells from Staphylococcus aureus and Pseudomonas aeruginosa infections
Authors: S. Affhan, W. Dachang, Y. Xin and D. Shang
Staphylococcus aureus and Pseudomonas aeruginosa are opportunistic pathogens that cause nosocomial and food-borne infections. They promote intestinal diseases. Gastrointestinal colonization by S. aureus and P. aeruginosa has rarely been researched. These organisms spread to extra gastrointestinal niches, resulting in increasingly progressive infections. L.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.16.5
- DOI:
- 10.4238/2015.December.16.5
Cellular responses induced in vitro by iron (Fe) in a central nervous system cell line (U343MGa)
Authors: D.D.F.A. Alc�¢ntara, H.F. Ribeiro, L.A. Matos, J.M.C. Sousa, R.R. Burbano and M.O. Bahia
Iron is the most important metallic chemical element on Earth. Poisoning caused by excessive iron in humans has been associated with pulmonary diseases including neoplasms caused by inhalation of iron oxides. The involvement of iron in neurodegenerative processes has already been described. DNA alterations are induced by iron and other chemical compounds .. Read More»
- Genet. Mol. Res. 12(2):
- 2013.May.13.9
- DOI:
- 10.4238/2013.May.13.9
Agrobacterium-mediated transformation of Fusarium proliferatum
Authors: J. Bernardi-Wenzel, M.C. Quecine, J.L. Azevedo and J.A. Pamphile
Fusarium proliferatum is an important pathogen that is associated with plant diseases and primarily affects aerial plant parts by producing different mycotoxins, which are toxic to humans and animals. Within the last decade, this fungus has also been described as one of the causes of red root rot or sudden death syndrome in so.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027944
- DOI:
- 10.4238/gmr.15027944