Medical Genetics
Increased miR-155-5p expression in dermal mesenchymal stem cells of psoriatic patients: comparing the microRNA expression profile by microarray
Authors: R.X. Hou, R.F. Liu, X.C. Zhao, Y.R. Jia, P. An, Z.P. Hao, J.Q. Li, X.H. Li, G.H. Yin and K.M. Zhang
Mesenchymal stem cells (MSCs) have pleiotropic immuno-modulatory effects and pro-angiogenic ability, leading to the presumption that MSCs may be involved in the pathogenesis of many inflammatory or autoimmune disorders, including psoriasis. In a previous study, we reported the specific gene expression profile ofdermal MSCs fro.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038631
- DOI:
- 10.4238/gmr.15038631
Rituximab regulates the expression of the Raf kinase inhibitor protein via NF-�ºB in renal tissue of rats with diabetic nephropathy
Authors: L. Li, Y.W. Zhao, J.S. Zeng, F. Fan, X. Wang, Y. Zhou and Z. Zhu
This study aimed to investigate the expression levels of the Raf kinase inhibitor protein (RKIP) and NF-κB in renal tissues of diabetic nephropathy (DN) rats, and to determine the underlying molecular targets of rituximab (RTX), with the goal of developing new clinical treatment selection for DN. Sprague-Dawley rats were randomly divided into a norm.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.August.16.1
- DOI:
- 10.4238/2013.August.16.1
Analysis of allelic variants of rdxA associated with metronidazole resistance in Helicobacter pylori: detection of common genotypes in rdxA by multiplex allele-specific polymerase chain reaction
Authors: T.R.P. Butlop, N.T.N. Mungkote and N.T.R. Chaichanawongsaroj
Resistance to metronidazole (Mtz) in Helicobacter pylori is a major problem worldwide, especially in developing countries. Alterations in Mtz nitroreductase enzymes, such as oxygen-insensitive NADPH nitroreductase (RdxA) and NADPH flavin oxidoreductase (FrxA), are the major contributing factors for this resistance. In this stu.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038674
- DOI:
- 10.4238/gmr.15038674
Methylation differences and expression profiles of the caprine DIO3 gene
Authors: H. Zhang, P.F. Jin, L.L. Niu, L. Li, L.J. Wang, Y. Chen, G.J. Zhang, H.P. Zhang and T. Zhong
DIO3 gene encoding type 3 iodothyronine deiodinase is an imprinted gene, located in the DLK1-DIO3 (delta-like 1 homolog-type 3 iodothyronine deiodinase) imprinted domain, and is potentially involved in degrading excessive amounts of thyroid hormone to protect embryogenesis. However, the underlying regulatory mechanism of the imprinted DIO3 gene expression.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038678
- DOI:
- 10.4238/gmr.15038678
Genetic diversity analysis of Varronia curassavica Jacq. accessions using ISSR markers
Authors: F.A. Brito, D.A.C. Nizio, A.V.C. Silva2 L.E.C. Diniz, A.R.C. Rabbani, M.F. Arrigoni-Blank, S.V. Alvares-Carvalho, G.M. Figueira, I. Montanari J�ºnior and A.F. Blank
Varronia curassavica Jacq. is a medicinal and aromatic plant from Brazil with significant economic importance. Studies on genetic diversity in active germplasm banks (AGB) are essential for conservation and breeding programs. The aim of this study was to analyze the genetic diversity of V. curassavica accessions of the AGB of Medicinal and Aromatic Plants.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038681
- DOI:
- 10.4238/gmr.15038681
Growth factor progranulin blocks tumor necrosis factor-�±-mediated inhibition of osteoblast differentiation
Authors: N. Wang, J. Zhang and J.X. Yang
Tumor necrosis factor-a (TNF-a) stimulates osteoclast differentiation and suppresses osteoblast differentiation, leading to bone loss and decreased bone mass in local inflammation areas in patients with rheumatoid arthritis. The growth factor progranulin (PGRN) is expressed in various types of cells and play crucial roles in t.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038126
- DOI:
- 10.4238/gmr.15038126
Investigating the association between XRCC1 gene polymorphisms and susceptibility to gastric cancer
Authors: S. Chen, X.C. Zhu, Y.L. Liu, C. Wang and K.G. Zhang
We carried out a hospital-based case-control study to investigate the role of XRCC1 gene Arg399Gln, Arg280His, and Arg194Trp polymorphisms in susceptibility to gastric cancer. A total of 214 gastric cancer patients and 247 control subjects were recruited between March 2013 and March 2015, and polymorphism genotype frequencies .. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038342
- DOI:
- 10.4238/gmr.15038342
Comparative analysis of short tandem repeat data obtained by automated and gel electrophoresis techniques
Authors: U.R. Pagel, R.S. Reis, V.P. Carvalho, E.V.W. Santos, E. Zandonade, I.D. Louro and F. Paula
Short tandem repeats (STRs) are commonly used as genetic markers. The detection and analysis of STRs can be used to gather information on polymorphisms of interest to forensic geneticists. Denaturing polyacrylamide gel electrophoresis (PAGE) is an affordable method for the detection of minor sequence changes in DNA, while capi.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038436
- DOI:
- 10.4238/gmr.15038436
Contributions of polymorphisms in miR146a, miR196a, and miR499 to the development of hepatocellular carcinoma
Authors: L.H. Zhang, B.B. Hao, C.Y. Zhang, X.Z. Dai and F. Zhang
Hepatocellular carcinoma is one of the most common malignant tumors worldwide; it is estimated that there were 782,000 new cases in 2012. MicroRNAs (miRNAs) play an important role in carcinogenesis by regulating oncogenes and tumor suppressors. We investigated the role of miR-146a, miR-196a2, and miR-499 polymorphisms in the r.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038582
- DOI:
- 10.4238/gmr.15038582
Investigation of NQO1 genetic polymorphism, NQO1 gene expression and PAH-DNA adducts in ESCC. A case-control study from Iran
Authors: H.A. Marjani, F. Biramijamal, N. Rakhshani, A. Hossein-Nezhad and R. Malekzadeh
We evaluated the effect of NQO1 genetic variation on PAH-DNA adducts in esophageal squamous cell carcinoma (ESCC) in northeast Iran. Golestan Province in northeast of Iran has one of the highest esophageal cancer incidences in the world. The study included 93 ESCC cases and 50 control individuals who were seen at the clinical .. Read More»
- Genet. Mol. Res. 9(1):
- vol9-1gmr693
- DOI:
- 10.4238/vol9-1gmr693