Medical Genetics
In silico prediction of conserved vaccine targets in Streptococcus agalactiae strains isolated from fish, cattle, and human samples
Authors: U.P. Pereira, S.C. Soares, J. Blom, C.A.G. Leal, R.T.J. Ramos, L.C. Guimar�£es, L.C. Oliveira, S.S. Almeida, S.S. Hassan, A.R. Santos, A. Miyoshi, A. Silva, A. Tauch, D. Barh, V. Azevedo and H.C.P. Figueiredo
Streptococcus agalactiae (Lancefield group B; group B streptococci) is a major pathogen that causes meningoencephalitis in fish, mastitis in cows, and neonatal sepsis and meningitis in humans. The available prophylactic measures for conserving human and animal health are not totally effective and have limitations. Effective vaccines against the different .. Read More»
- Genet. Mol. Res. 12(3):
- 2013.August.12.6
- DOI:
- 10.4238/2013.August.12.6
Expression of COX-2 and VEGF-C in cholangiocarcinomas at different clinical and pathological stages
Authors: Z. You, L. Bei, L.P. Cheng and N.S. Cheng
The aim of this study was to investigate the expression and clinical significance of cyclooxygenase 2 (COX-2) and vascular endothelial growth factor C (VEGF-C) in cholangiocarcinomas at different clinical and pathological stages. Eighty cholangiocarcinoma samples of patients treated with surgery between January 2012 and January 2014 were collected. Immuno.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.9.9
- DOI:
- 10.4238/2015.June.9.9
Diffuse large B-cell lymphoma in the primary bone marrow
Authors: Y. Hu, S.L. Chen, Z.X. Huang, W. Gao and N. An
This study aimed to improve understanding of the diagnosis, treatment, and prognosis of primary bone marrow (PBM) diffuse large B-cell lymphoma (DLBCL), a rare illness. We report a 56-year-old man with pancytopenia and hyperbilirubinemia but without lymphadenopathy, hepatomegaly, or splenomegaly. Bone marrow aspiration, flow cytometry, biopsy, and immunoh.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.9.10
- DOI:
- 10.4238/2015.June.9.10
Quantitative analysis of P16 gene CpG methylation in Uyghur patients with cervical squamous cell carcinoma and its relationship with HPV16 infection
Authors: J.-X. Cheng, M. Yuan, A.-L. Li, P. Zhou, G.-Q. Shen and Y. Zhang
The methylation of CpG sites in the promoter region of the P16 gene in Uyghur patients with cervical squamous cell carcinoma (CSCC) was quantitatively analyzed and its relationship with human papillomavirus 16 (HPV16) infection was explored. Cervical samples were collected from 20 Uyghur patients with CSCC and 20 Uyghur controls. Matrix-assisted .. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.12.9
- DOI:
- 10.4238/2014.September.12.9
Association between the FCGR2A gene H131R polymorphism and risk of Kawasaki disease: a meta-analysis
Authors: L. Lin, S.Y. Wang, S.B. Yang and F.C. Xiao
Several previous studies have investigated whether the FCGR2A gene H131R polymorphism confers an increased risk of Kawasaki disease (KD), but conflicting results have been reported. To further explore the association of this polymorphism with KD susceptibility, we performed an extensive search of relevant studies and conducted a meta-analysis to obtain a .. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.9.12
- DOI:
- 10.4238/2015.June.9.12
Associations of miRNA polymorphisms and expression levels with breast cancer risk in the Chinese population
Authors: P. Qi, L. Wang, B. Zhou, W.J. Yao, S. Xu, Y. Zhou and Z.B. Xie
Single-nucleotide polymorphisms in microRNAs (miRNAs) may dramatically affect gene expression and subsequently alter individual susceptibility to cancer, and thus has become a research hotspot for many cancer types, including breast cancer. We recruited 321 breast cancer patients and 290 controls in our study. Four established miRNA single-nucleotide poly.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.11.2
- DOI:
- 10.4238/2015.June.11.2
Cardioprotective effects mitochondrial ATP-sensitive potassium channel in exercise conditioning
Authors: F.-L. Peng, Y.-J. Guo, W.-B. Mo, S.-M. Xu and H.-P. Liao
We investigated the mitochondrial ATP-sensitive potassium channel [mito-K (ATP)] in exercise preconditioning of myocardial ischemia-reperfusion injury in rats. Eighty SD rats were randomly divided into high-, moderate-, low-intensity, and control groups. The exercise groups were divided into control and inhibited groups. The c.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.12.17
- DOI:
- 10.4238/2014.September.12.17
Association of MLL3 expression with prognosis in gastric cancer
Authors: B. Li, H.Y. Liu, S.H. Guo, P. Sun, F.M. Gong and B.Q. Jia
Low expression of myeloid/lymphoid or mixed-lineage leukemia 3 (MLL3) is reportedly associated with gastric cancer and tumor progression. The purpose of this study was to examine the expression of MLL3 in tissue samples of patients with gastric cancer and to analyze the relationship between MLL3 protein expression and clinical.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.12.18
- DOI:
- 10.4238/2014.September.12.18
Relationship between TLR4 and MCP2 expression levels and habitual abortion
Authors: X.P. Li, L.N. Song, L.P. Tian and Y.S. Zhang
Habitual abortion is associated with the altered expression of multiple genes. This study was carried out to investigate the relationship between expression of Toll-like receptor 4 (TLR4) and monocyte chemotactic protein 2 (MCP2 or CCL8) and habitual abortion. This was done by detecting and comparing their relative expression .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027378
- DOI:
- 10.4238/gmr.15027378
Effect of polychlorinated biphenyls on osmoregulatory response and apoptosis in GIFT tilapia, Oreochromis niloticus
Authors: Y. Zheng, L. Qiu, L. Fan, C. Song, S. Meng and J. Chen
In the present study, GIFT tilapia Oreochromis niloticus were exposed to polychlorinated biphenyls (PCBs) for 7, 14, and 21 days. Over the duration of the exposure, genotoxicity and the activity of Na+/K+-ATPase (NKA) and Ca+/Mg+-ATPase (CMA) were measured in the gill, kidney, and intestine, to evaluate changes in osmoregulatory response in O. niloticus. .. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038620
- DOI:
- 10.4238/gmr.15038620