Medical Genetics
Association between polymorphisms in ADAM33, CD14, and TLR4 with asthma in the Uygur population in China
Authors: J. Wang, M. Simayi, Q. Wushouer, Y. Xia, Y. He, F. Yan, J. Zhang, S. Cui and H. Wen
We evaluated the associations between single nucleotide polymorphisms (SNPs) and haplotypes of the genes encoding a disintegrin and metalloproteinase 33 (ADAM33), cluster of differentiation 14 (CD14), and Toll-like receptor 4 (TLR4) and the susceptibility of developing specific adult phenotypes of bronchial asthma in a Chinese.. Read More»
- Genet. Mol. Res. 13(2):
- 2014.June.18.11
- DOI:
- 10.4238/2014.June.18.11
Role of ABCB1 C1236T, G2677T, and C3435T genetic polymorphisms in the development of acute leukemia in a Chinese population
Authors: R. Feng, H.X. Zhang, H.G. Zhang and C.F. Zhang
We carried out a case-control study to examine the relationship between the ATP-binding cassette subfamily B member 1 (ABCB1) gene polymorphisms C1236T, G2677T, and C3435T and risk of acute leukemia in a Chinese population. Between May 2013 and April 2015, we recruited 164 acute leukemia patients and 285 healthy controls, and .. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038546
- DOI:
- 10.4238/gmr.15038546
Comparative analysis of soybean genotype resistance to Heterodera glycines and Meloidogyne species via resistance gene analogs
Authors: P.M.H. Vieira, F.A.S. Ar�ªdes, A. Ferreira and M.F.S. Ferreira
Nematodes are important pests of soybean throughout the world and cause high yield losses. As a control strategy, the identification of resistance genes is an important aim of breeding studies. Plants possess resistance genes (R), which are responsible for the recognition of pathogens and activation of the defense system. R ge.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038562
- DOI:
- 10.4238/gmr.15038562
Association of ectomycorrhizal fungi with Picea crassifolia (Pinaceae, Piceoidae) from high-altitude stands in Mount Helan Nature Reserve, China
Authors: Y.J. Fan, T. Grebenc, J. Wei, Y.L. Zhao, W. Yan and L.B. Wang
We investigated the diversity of ectomycorrhiza associated with the endemic Picea crassifolia in Mount Helan National Nature Reserve in Inner Mongolia, China. Toward this objective, we conducted morphological and molecular identification of ectomycorrhizae in soil cubes taken from pure P. crassifolia stands. Eleven types of ec.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038604
- DOI:
- 10.4238/gmr.15038604
Gametocidal chromosomes enhancing chromosome aberration in common wheat induced by 5-azacytidine
Authors: W.-Y. Su, W.-W. Cong, Y.-J. Shu, D. Wang, G.-H. Xu, C.-H. Guo
The gametocidal (Gc) chromosome from Aegilops spp induces chromosome mutation, which is introduced into common wheat as a tool of chromosome manipulation for genetic improvement. The Gc chromosome functions similar to a restriction-modification system in bacteria, in which DNA methylation is an important regulator. We treated root tips of wheat carrying G.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.July.8.4
- DOI:
- 10.4238/2013.July.8.4
Genes, genome and Gestalt
Authors: Cesar Koppe Grisolia
According to Gestalt thinking, biological systems cannot be viewed as the sum of their elements, but as processes of the whole. To understand organisms we must start from the whole, observing how the various parts are related. In genetics, we must observe the genome over and above the sum of its genes. Either loss or addition .. Read More»
- Genet. Mol. Res. 4(1):
High leptin level and leptin receptor Lys656Asn variant are risk factors for preeclampsia
Authors: S. Wang, F.Y. Qiao and L. Feng
The aim of this study was to investigate the relationship between the leptin receptor (LEPR) polymorphism/serum leptin level and preeclampsia. The prevalence of a single nucleotide polymorphism in the LEPR gene exon 14 at -656 and the serum leptin concentrations in 97 preeclamptic pregnant mothers were compared to those of 110 healthy controls. The Lys656.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.January.4.14
- DOI:
- 10.4238/2013.January.4.14
Phylogenetic analyses of the hemagglutinin gene of wild-type strains of canine distemper virus in southern Brazil
Authors: F.J. Negr�£o, N.R. Gardinali, S.A. Headley, A.A. Alfieri, M.A. Fernandez and A.F. Alfieri
This study examined the phylogenetic relationship of strains of canine distemper virus (CDV) collected from Paraná State, Brazil, based on the hemagglutinin gene. Urine samples were collected from 4 dogs from northern Paraná State that demonstrated clinical manifestations of canine distemper. The participation of CDV was initially confirmed .. Read More»
- Genet. Mol. Res. 12(3):
- 2013.March.11.2
- DOI:
- 10.4238/2013.March.11.2
Novel tetranucleotide microsatellite markers for Chinese beard eel (Cirrhimuraena chinensis Kaup)
Authors: H. Li, T.M. Ge, S.X. Ding and H.J. Wang
In this study, we characterized 12 novel polymorphic microsatellite loci for Chinese beard eel (Cirrhimuraena chinensis Kaup) from a tetranucleotide microsatellite-enriched library. Loci screened on a sample of 37 individuals from Xiamen wild stocks revealed 8 to 24 alleles per locus, with a mean of 13.83 over all loci. Observed and expected heterozygosit.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.August.2.3
- DOI:
- 10.4238/2013.August.2.3
GSTM1 and GSTT1 polymorphisms in endometriosis in women from Goi�¡s, Brazil
Authors: A.B. Frare, A.M. Barbosa, I.R. Costa, S.R. Souza, R.C.P.C. Silva, B.M. Bordin, C.L. Ribeiro J�ºnior and K.K.V.O. Moura
Endometriosis is a gynecologic pathology with a high prevalence and unknown etiology. Therefore, an increasing number of studies has been undertaken to search for associations between endometriosis and alterations or polymorphisms in candidate genes, including glutathione S-transferase mu 1 (GSTM1) and glutathione S-transferase theta 1 (GSTT1). We analyze.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.August.2.1
- DOI:
- 10.4238/2013.August.2.1