Medical Genetics
Different responses of vanillic acid, a phenolic compound, in HTC cells: cytotoxicity, antiproliferative activity, and protection from DNA-induced damage
Authors: I.V. Almeida, F.M.L. Cavalcante and V.E.P. Vicentini
The consumption of healthy and natural foods has increased over the last few years, primarily because these foods are rich in substances with biological properties of interest, such as exerting anticancer effects and decreasing oxidative stress in living tissues. These foods support adequate nutrition, maintain health, and imp.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15049388
- DOI:
- 10.4238/gmr15049388
Tim-3 facilitates osteosarcoma proliferation and metastasis through the NF-�ºB pathway and epithelial-mesenchymal transition
Authors: Z.M. Feng and S.M. Guo
The aim of this study was to investigate the expression of T-cell immunoglobulin mucin domain molecule-3 (Tim-3) in osteosarcoma tissues, and analyze its effect on cell proliferation and metastasis in an osteosarcoma cell line. Tim-3 mRNA and protein expression in osteosarcoma tissue was detected by reverse transcriptase-polym.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15037844
- DOI:
- 10.4238/gmr.15037844
Association of single-nucleotide polymorphisms, rs2235371 and rs2013162, in the IRF6 gene with non-syndromic cleft palate in northeast China
Authors: W. Xu, W.T. Han, Y.P. Lu, W.H. Feng and M. Dai
The aim of this study was to determine the association between two SNPs (rs2235371 and rs2013162) in the interferon regulatory factor 6 (IRF6) gene and non-syndromic cleft palate (NSCP) in northeast China. We genotyped these two SNPs in 104 NSCP cases, as well as in 178 parents and 300 controls. Case-control and case-parent an.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038210
- DOI:
- 10.4238/gmr.15038210
Reversal of cisplatin resistance in non-small cell lung cancer stem cells by Taxus chinensis var.
Authors: Y.Q. Jiang, X.P. Xu, Q.M. Guo, X.C. Xu, Q.Y. Liu, S.H. An, J.L. Xu, F. Su and J.B. Tai
Drug resistance in cells is a major impedance to successful treatment of lung cancer. Taxus chinensis var. inhibits the growth of tumor cells and promotes the synthesis of interleukins 1 and 2 and tumor necrosis factor, enhancing immune function. In this study, T. chinensis var.-induced cell death was analyzed in lung cancer c.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038336
- DOI:
- 10.4238/gmr.15038336
Effects of ginsenoside Rg1 on the senescence of vascular smooth muscle cells
Authors: S.G. Li, M.Z. Yan, D. Zhang, M. Ye and J.J. Deng
The development of age-related cardiovascular disease is associated with the senescence of vascular cells. This study aimed to investigate the effect of ginsenoside Rg1 on vascular smooth muscle cell (VSMC) senescence. Primary VSMCs were cultured and divided into control, D-galactose (D-gal), Rg1-L, and Rg1-H groups, which wer.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038409
- DOI:
- 10.4238/gmr.15038409
Characterization and comparison of EST-SSR and TRAP markers for genetic analysis of the Japanese persimmon Diospyros kaki
Authors: C. Luo, F. Zhang, Q.L. Zhang, D.Y. Guo and Z.R. Luo
We developed and characterized expressed sequence tags (ESTs)-simple sequence repeats (SSRs) and targeted region amplified polymorphism (TRAP) markers to examine genetic relationships in the persimmon genus Diospyros gene pool. In total, we characterized 14 EST-SSR primer pairs and 36 TRAP primer combinations, which were amplified across 20 germplasms of .. Read More»
- Genet. Mol. Res. 12(3):
- 2013.January.9.3
- DOI:
- 10.4238/2013.January.9.3
Antimutagenicity and antigenotoxicity of Aloe arborescens Miller and Aloe barbadensis Miller in Aspergillus nidulans and Wistar rats
Authors: A.P. Berti, G.F. Palioto and C.L.M.S.C. Rocha
Medicinal plants such as Aloe arborescens Miller and Aloe barbadensis Miller are used by the general population to treat various diseases. Therefore, the aim of this study was to evaluate the antimutagenicity of these two species using a methG1 system in Aspergillus nidulans and the comet assay in rats. The animals were treate.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038522
- DOI:
- 10.4238/gmr.15038522
Role of miR-149C>T polymorphisms on the risk of hepatocellular carcinoma in a Chinese population
Authors: M.F. Liu, W.Q. Chen, Y.Z. He and Y.L. Gu
MicroRNAs (miRNAs) are thought to play a role in cancer development. We conducted a case-control study to investigate the association between polymorphisms in miR-149C>T and hepatocellular carcinoma (HCC) risk. Duplex polymerase chain reaction with the confronting 2-pair primers were taken to genotype miR-149C>T. The ass.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.5.4
- DOI:
- 10.4238/2014.September.5.4
Association of c.461G>A genetic variant of OGG1 gene with pancreatic cancer susceptibility in Chinese
Authors: Z.M. Zhao, C.G. Li, M.G. Hu, G.D. Zhao and R. Liu
This study aimed to evaluate the potential association of single nucleotide polymorphisms of the 8-oxoguanine DNA glycosylase gene (OGG1) with susceptibility to pancreatic cancer (PC). A total of 764 Chinese Han subjects were recruited in this study. The polymerase chain reaction-restriction fragment length polymorphism and DN.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.5.10
- DOI:
- 10.4238/2014.September.5.10
Torasemide reduces dilated cardiomyopathy, complication of arrhythmia, and progression to heart failure
Authors: L.N. Han, S.L. Guo, X.M. Lin, X.M. Shi, C.B. Zang, L.M. Yang and G.L. Ding
The aim of this study was to analyze the incidence and types of arrhythmia and their relationship with the severity and prognosis of chronic heart failure (CHF) in patients with dilated cardiomyopathy (DCM), and to investigate the therapeutic effect of torasemide versus furosemide on CHF and incidence of arrhythmia. DCM patien.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.5.11
- DOI:
- 10.4238/2014.September.5.11