Medical Genetics
Association of serum adipose triglyceride lipase levels with obesity and diabetes
Authors: L. Yang, S.J. Chen, G.Y. Yuan, L.B. Zhou, D. Wang, X.Z. Wang and J.J. Chen
The aim of this study was to detect the serum adipose triglyceride lipase (ATGL) levels in obesity and newly diagnosed type 2 diabetes patients, and to explore the association between ATGL with glucose and lipid metabolism. We enrolled 66 patients with type 2 diabetes and 48 patients with normal glucose regulation, who were di.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.August.28.18
- DOI:
- 10.4238/2014.August.28.18
Genetic variability for iron and zinc content in common bean lines and interaction with water availability
Authors: H.S. Pereira, M.J. Del Peloso, P.Z. Bassinello, C.M. Guimar�£es, L.C. Melo and L.C. Faria
The common bean is an important source of iron and zinc in humans. Increases in the contents of these minerals can combat mineral deficiencies, but these contents are influenced by environmental conditions. Thus, the objectives of this study were to investigate the interaction between common bean lines and water availability o.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.August.28.21
- DOI:
- 10.4238/2014.August.28.21
Visualization and body distribution of [131I]-herceptin in nude mice with BT-474 breast carcinoma
Authors: Z.X. Yang, H. Cao*, C.G. Xing, S.H. Wei, G.Q. Jiang and Z.L. Liu
The study aimed to investigate the bio-distribution and radio-immuno-imaging features of [131I]-herceptin in nude mice with BT-474 breast carcinoma. [131I]-Herceptin was administrated by tail intravenous injection to the nude mice with BT-474 breast carcinoma. Radiocounting was performed at 4, 12, 24, 48,.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.August.29.1
- DOI:
- 10.4238/2014.August.29.1
Effects of high thoracic epidural anesthesia on ischemic cardiomyopathy cardiac function and autonomic neural function
Authors: X. Wang, G.Y. Chen, S.S. Yang, Y. Tian, T. Ge2, H. Qin, W. Han and H.Y. Chang
We aimed at observing the effects of high thoracic epidural anesthesia (HTEA) on cardiac structure and function, heart rate variability (HRV), and QT interval variation (QTV) in ischemic cardiomyopathy (ICM) patients with chronic heart failure. We divided 30 ICM patients into HTEA (N = 16) and control (N = 14) groups.The contr.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.August.29.2
- DOI:
- 10.4238/2014.August.29.2
Association between the c.1564A>T genetic polymorphism of the MDR1 gene and hepatocellular carcinoma in Chinese population
Authors: Y.Y. Wan, X.W. Wang, H.X. Hui and L. Wan
The objective of this study was to evaluate the influence of c.1564A>T genetic polymorphisms in the multidrug resistance 1 gene (MDR1) on hepatocellular carcinoma (HCC) susceptibility through association analysis. A total of 632 HCC patients and 645 cancer-free controls were enrolled in this study. The c.1564A>T genetic .. Read More»
- Genet. Mol. Res. 13(3):
- 2014.August.29.3
- DOI:
- 10.4238/2014.August.29.3
Magnetic resonance spectroscopic imaging of brain injury after nasopharyngeal cancer radiation in early delayed reaction
Authors: W.-S. Chen, J.-J. Li, J.-H. Zhang, L. Hong, Z.-B. Xing, F. Wang and C.-Q. Li
This study aimed to investigate the value of magnetic resonance spectroscopy (MRS) imaging in assessing nasopharyngeal carcinoma radiotherapy during the early delayed reaction period. Eighty cases of nasopharyngeal cancer treated with radiotherapy within the same period underwent MRS imaging before or after radiotherapy. Of th.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.August.29.6
- DOI:
- 10.4238/2014.August.29.6
Ultrasonic imaging characteristics of transplanted kidneys with delayed graft function
Authors: W.X. Liang, M.J. Cai, L. Jiang, Y.Q. Xie, W.L. Yuan and H. Zhang
We investigated the ultrasonic imaging characteristics of transplanted kidneys with delayed graft function (DGF). Ultrasonography was performed in 44 patients after kidney transplantation, and a time-intensity analysis was performed to compare the differences between patients with normal graft function (NGF) and those with DGF.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.August.29.9
- DOI:
- 10.4238/2014.August.29.9
Cytotoxicity and DNA damage in mouse macrophages exposed to silica nanoparticles
Authors: H. Yang1, Q.Y. Wu1,2, C.S. Lao1, M.Y. Li1, Y. Gao1, Y. Zheng1 and B. Shi3
Silica (SiO2) nanoparticles are being progressively applied in various applications, including cosmetics, food technology, and medical diagnostics. Although crystalline SiO2 is a known carcinogen, the carcinogenicity of SiO2 nanoparticles remains unclear. Here, we assessed the cytotoxic effects and DNA injury induced by exposu.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15039005
- DOI:
- 10.4238/gmr.15039005
Reduction of galectin-3 expression reduces pituitary tumor cell progression
Authors: C.X. Huang, J.N. Zhao, W.H. Zou, J.J. Li, P.C. Wang, C.H. Liu and Y.B. Wang
We investigated the role of galectin 3 in the development and progression of pituitary tumors. We used RNA interference to depress Gal-3 gene expression; MTT and flow cytometry were applied to detect changes in cell proliferation and apoptosis levels in pituitary tumor cells. Expression of apoptosis-associated genes, Bcl-2 and.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.August.29.11
- DOI:
- 10.4238/2014.August.29.11
Novel single nucleotide polymorphisms in the 5' regulatory region of the duck SCD1 gene and their associations with serum biochemical levels and fatty acid composition
Authors: W.-G. Li, Y.-Y. Zhang and D.-D. Wang
Stearoyl-coenzyme A desaturase 1 (SCD1) is the key limiting enzyme in the synthesis of monounsaturated fatty acids, and plays a crucial role in the regulation of oleic acid. In this study, 165 ten-week-old Cherry Valley ducks were used to investigate single nucleotide polymorphisms (SNPs) in the 5' regulatory region of the SCD.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15039007
- DOI:
- 10.4238/gmr.15039007