Medical Genetics
Common polymorphisms of the microRNA genes (miR-146a and miR-196a-2) and gastric cancer risk: an updated meta-analysis
Authors: Z.F. Chen, L.L. Ma and H.B. Xue
The associations between two common polymorphisms in microRNA genes (miR-146a, dbSNP: rs2910164; miR-196a-2, dbSNP: rs11614913) and gastric cancer risk have frequently been examined; however, the results have often been controversial. This meta-analysis was performed to clarify the association between the two polymorphisms and gastric cancer risk. The lit.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.31.7
- DOI:
- 10.4238/2015.July.31.7
Relationship among physiological quality, heterosis, and amylase gene expression in maize seeds
Authors: G.E. Oliveira, E.V.R. Von Pinho, T. Andrade, J.C. Souza, F. Caixeta and R.A.D.C. Ferreira
In this study, we analyzed heterosis, amylase enzyme gene expression, and the physiological quality of maize seeds with different genotypes and sizes, which were subjected to aging and not subjected to aging. We used seeds from 2 maize lines that differed with regard to physiological quality, the hybrid, and the reciprocal hybrid; they were classified int.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.31.10
- DOI:
- 10.4238/2015.July.31.10
BORIS and CTCF are overexpressed in squamous intraepithelial lesions and cervical cancer
Authors: N. Vel?¡zquez-Hern?¡ndez, M.A. Reyes-Romero, M. Barrag?¡n-Hern?¡ndez, F. Guerrero-Romero, M. Rodr?guez-Moran, M. Aguilar-Dur?¡n and B. Lazalde Medina
We investigated the expression of Brother of Regulator of Imprinted Sites (BORIS) and CCCTC-binding factor (CTCF) in squamous intraepithelial lesions and cervical cancer. To analyze BORIS and CTCF expression, an endocervical cytobrush sample was taken for total RNA isolation. CTCF and BORIS mRNA was quantified from total RNA using quantitative reverse tra.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.8.7
- DOI:
- 10.4238/2015.June.8.7
Transplantation of umbilical cord blood mononuclear cells increases levels of nerve growth factor in the cerebrospinal fluid of patients with autism
Authors: Q. Li1,, C.-F. Chen, D.-Y. Wang, Y.-T. L?¼, Y. Huan, M. Liu, R.-C. Ge, X.-W. Chen, H.-S. Qi, L. An and X. Hu
We aimed to evaluate the levels of growth factors in the cerebrospinal fluid (CSF) of patients with autism after transplantation of umbilical cord blood mononuclear cells (CBMNCs). Fourteen subjects diagnosed with autism received transplantation of CBMNCs first through intravenous infusion, and three times subsequently through intrathecal injections. A 2-.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.31.21
- DOI:
- 10.4238/2015.July.31.21
Vitamin D receptor FokI gene polymorphism and tuberculosis susceptibility: a meta-analysis
Authors: Y.P. Sun and Q.S. Cai
Numerous studies have evaluated the association between FokI polymorphisms in the vitamin D receptor (VDR) gene and tuberculosis risk. However, the specific association remains controversial. In this study, we performed a meta-analysis to assess the association between the VDR gene FokI polymorphism and tuberculosis. Published studies from the PubMed and .. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.9.1
- DOI:
- 10.4238/2015.June.9.1
Association of the g.19074G>A genetic variant in the osteoprotegerin gene with bone mineral density in Chinese postmenopausal women
Authors: Y.D. Zhang, Z. Zhang, N.F. Zhou, W.T. Jia, X.G. Cheng and X.J. Wei
Primary osteoporosis is a common health problem in postmenopausal women. This study aimed to detect the association of the g.19074G>A genetic variant in the osteoprotegerin gene (OPG) with bone mineral density (BMD) and primary osteoporosis. The created restriction site-polymerase chain reaction method was used to .. Read More»
- Genet. Mol. Res. 13(3):
- 2014.August.28.9
- DOI:
- 10.4238/2014.August.28.9
Characterization of EST-derived and non-EST simple sequence repeats in an F1 hybrid population of Vitis vinifera L.
Authors: E. Kayesh, N. Bilkish, G.S. Liu, W. Chen, X.P. Leng and J.G. Fang
Among different classes of molecular markers, expressed sequence tags (ESTs) are a new resource for developing simple sequence repeat (SSR) functional markers for genotyping and genetic mapping in F1 hybrid populations of Vitis vinifera L. Recently, because of the availability of an enormous amount of data for ESTs in the publ.. Read More»
- Genet. Mol. Res. 13(1):
- 2014.March.31.2
- DOI:
- 10.4238/2014.March.31.2
One â??8â?-shaped scleral suture to treat rhegmatogenous retinal detachment: a refined procedure of minimal scleral buckling
Authors: H.Y. Min, D. Chen, Y. Chen and F.T. Dong
The aim of this study was to investigate the outcomes of one “8”-shaped scleral suture of minimal scleral buckling (MSB) surgery without sub-retinal drainage for rhegmatogenous retinal detachment (RRD) treatment. Thirty patients (30 eyes) with RRD were recruited. Thirty eyes with RRD were repaired by one “8&r.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.August.28.11
- DOI:
- 10.4238/2014.August.28.11
A novel missense mutation T101N in the melanocortin-4 receptor gene associated with obesity
Authors: S. Buchbinder, U. B?¤rtsch, M. M?¼ller, M. Zorn, P.P. Nawroth and T. Schilling
Mutations in the melanocortin-4 receptor (MC4R) are associated with severe obesity, independent of their effect on cortisol or thyroid-stimulating hormone levels. We examined a morbidly obese male (BMI = 62 kg/m2) with a binge-eating disorder and eight family members for mutations in the MC4R gene and potential differences in .. Read More»
- Genet. Mol. Res. 10(2):
- vol10-2gmr948
- DOI:
- 10.4238/vol10-2gmr948
Efficient delivery of connective tissue growth factor shRNA using PAMAM nanoparticles
Authors: Z.J. Huang, B. Yi, H. Yuan and G.P. Yang
The aim of this study was to detect the anti-fibrosis activity of connective tissue growth factor (CTGF) small hairpin RNA (shRNA) mediated by polyamidoamine dendrimer nanoparticles in rat myocardial cell lines and myocardium. CTGF shRNAs were constructed from inverted oligonucleotides and a polyamidoamine nanoparticle vector .. Read More»
- Genet. Mol. Res. 13(3):
- 2014.August.28.15
- DOI:
- 10.4238/2014.August.28.15