Medical Genetics
Effect of leukocyte filtration on the P-selectin expression of apheresis platelets
Authors: Z.T. Xie, C. Chen, S.H. Zhang, H.M. Yang and Z.H. Tao
The aim of this study was to investigate the effect of leukocyte filtration on the P-selectin (CD62P) surface expression of apheresis platelets during the retention period. Ten bags of apheresis platelets stored for 1 day (0-24 h) and 10 bags of apheresis platelets stored for 2 days (24-48 h) were used for leukocyte filtration (experimental group). Ten ba.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.1.15
- DOI:
- 10.4238/2015.June.1.15
IL-6-174G/C and IL-6-572C/G polymorphisms are associated with increased risk of coronary artery disease
Authors: L. Li, E. Li, L.H. Zhang, L.G. Jian, H.P. Liu and T. Wang
We conducted this case-control study to investigate the genetic role of IL-1β+3954C/T, IL-6-174G/C, IL-6-572C/G, IL-10-1082A/G, and IL-10-819C/T in the development of coronary artery disease (CAD) in a Chinese population. Polymorphisms IL-1β+3954C/T, IL-6-174G/C, IL-6-572C/G, IL-10-1082A/G, and IL-10-819C/T were determined by polymerase chain re.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.28.12
- DOI:
- 10.4238/2015.July.28.12
Interleukin-6 gene -174G>C polymorphism and chronic obstructive pulmonary disease risk: a meta-analysis
Authors: X.M. Xie, R. Ke, Y.H. Zhang, G.Z. Wang, Y.T. Zhu, T. Hussian, L. Yang and M.X. Li
Association studies of interleukin-6 (IL-6) -174G>C polymorphism and chronic obstructive pulmonary disease (COPD) have yielded inconsistent results, possibly because single studies often lack sufficient statistical power. A comprehensive search was performed in the PubMed, Embase, Elsevier, Web of Science databases, Wanfang, and the Chinese National Kn.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.28.21
- DOI:
- 10.4238/2015.July.28.21
Smoking, aging, and expression of proteins related to the FOXO3 signaling pathway in lung tissues
Authors: Y.M. Yuan, L. Luo, Z. Guo, M. Yang, Y.F. Lin and C. Luo
We investigated the effects of smoking and aging on proteins involved in the forkhead box O3 (FOXO3) signaling pathways in the lungs. Sixteen senescence-accelerated mouse-resistant 1 (SAMR1) and senescence-accelerated mouse-prone 8 (SAMP8) mice at 3 months of age were divided into a normally aged, smoke-exposed group (4 SAMR1 mice), a normally aged, air-e.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.31.2
- DOI:
- 10.4238/2015.July.31.2
Curative effect and costs of surgical and gamma knife treatments on intractable epilepsy caused by temporal-hippocampal sclerosis
Authors: Z.T. Han and Q.X. Chen
This study aimed to investigate the curative effect and costs of surgical and gamma knife treatments on intractable epilepsy caused by temporal-hippocampal sclerosis. The subjects comprised patients who suffered from intractable epilepsy caused by temporal-hippocampal sclerosis and received treatment in the Department of Neurosurgery of our hospital betwe.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.31.3
- DOI:
- 10.4238/2015.July.31.3
Integrated miRNA-mRNA analysis of Epstein-Barr virus-positive nasopharyngeal carcinoma
Authors: L.H. Zhu, X.T. Miao and N.Y. Wang
This study aims to identify the crucial miRNAs in Epstein-Barr virus-positive nasopharyngeal carcinoma (NPC) and their target genes. Gene expression profile data (GSE12452) that included 31 NPC and 10 normal nasopharyngeal tissue specimens were downloaded. Differentially expressed genes (DEGs) were identified using significance analysis of microarrays. Th.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.1.20
- DOI:
- 10.4238/2015.June.1.20
Expression and antibody generation of the cancer-testis antigen, BIOT2-S
Authors: J.-Y. Wang, M. Cao, M.-R. Guo, S. Li, X.-F. Yang, M. Wang, J. Fang and J. Zhao
Biot2-S is a mouse cancer-testis antigen gene that was identified using the cross-reactive serological analysis of recombinant cDNA expression libraries (SEREX) technique in the State Key Laboratory of Biotherapy, West China Hospital, Sichuan University. To express BIOT2-S and generate its antibody for further investigation, the Biot2-S prokaryotic recomb.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.31.17
- DOI:
- 10.4238/2015.July.31.17
Cytogenetic characterization of species of the family Heptapteridae (Teleostei: Siluriformes) from the Cuiab�¡ and Iva� River Basins, Brazil
Authors: L.M. Barbosa, G.E.B. Ferreira, A.C. Prizon, A.L.B. Portela-Castro and I.C. Martins-Santos
We cytogenetically characterized three species of Heptapteridae (Pimelodella sp, Pimelodella taenioptera, and Imparfinis schubarti) by investigating the distribution of constitutive heterochromatin and nucleolar organizer regions by silver nitrate impregnation (Ag-NOR) and fluorescence in situ hybridization. Pimelodella sp showed had a diploid number (2n).. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.31.12
- DOI:
- 10.4238/2015.July.31.12
Study on the correlation between the expression of Ki67 and FasL and prognosis of cervical carcinoma
Authors: S.N. Liang, Y.J. Huang, L.L. Liu and X. Liu
This study aimed to investigate the correlation between the expression of Ki67 and FasL and prognosis of cervical carcinoma and to explore the biological processes and signal pathways related to cervical carcinoma. Cervical carcinoma tissue specimens from 200 patients and normal tissue specimens adjacent to lesions from 30 cases were collected in this stu.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.31.11
- DOI:
- 10.4238/2015.July.31.11
Adjuvant chemotherapy may improve survival of patients with luminal A breast cancer and positive lymph nodes
Authors: Y. Han, Q. Li, B.H. Xu, P. Zhang, P. Yuan, J.Y. Wang, F. Ma, R.G. Cai and Y. Fan
The study examined the clinicopathological characteristics and treatment options in patients with luminal A breast cancer. This retrospective cohort included 1580 patients with luminal A breast cancer treated between January 2005 and June 2007. Patients were divided into four subgroups according to lymph node status. Prognostic factors and 5-year overall .. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.31.4
- DOI:
- 10.4238/2015.July.31.4