Medical Genetics
Molecular variation of Sporisorium scitamineum in Mainland China revealed by internal transcribed spacers
Authors: Y.Y. Zhang, N. Huang, X.H. Xiao, L. Huang, F. Liu, W.H. Su and Y.X. Que
Sugarcane smut caused by the fungus Sporisorium scitamineum is a worldwide disease and also one of the most prevalent diseases in sugarcane production in mainland China. To study molecular variation in S. scitamineum, 23 S. scitamineum isolates from the 6 primary sugarcane production areas in mainland, China (Guangxi, Yunnan, Guangdong, Hainan, Fujian, an.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.14.15
- DOI:
- 10.4238/2015.July.14.15
Gene expression profiling of Duchenne muscular dystrophy reveals characteristics along disease progression.
Authors: L.J. Tian, J.H. Cao, X.Q. Deng, C.L. Zhang, T. Qian, X.X. Song and B.S. Huang
Duchenne muscular dystrophy (DMD) is the most common form of muscular dystrophy with no cure currently available. In this study, using two microarray data sets obtained from the Gene Expression Omnibus database, we conducted a dysfunctional pathway-enrichment analysis and investigated deregulated genes that are specific to dif.. Read More»
- Genet. Mol. Res. 13(1):
- http://dx.doi.org/2014.February.28.13
- DOI:
- http://dx.doi.org/10.4238/2014.February.28.13
Expression of a novel splicing variant of Pcp2 in closely related laboratory rodents
Authors: M.A. PrzybyÃ?Â?a, M.M. Nowacka-Chmielewska and J.J. Barski
Purkinje cell protein-2 (PCP2), also known as L7, is a member of the GoLoco protein family with highly cell-specific expression, being restricted to cerebellar Purkinje cells and retinal bipolar neurons in various species. However, its function in these tissues is unknown. Previous studies have suggested that PCP2 is a guanine nucleotide dissociation inhi.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038228
- DOI:
- 10.4238/gmr.15038228
Clinical significance of SHMT1 rs1979277 polymorphism in Asian solid tumors: evidence from a meta-analysis
Authors: T.T. Zhao, L.L. Shen, X.L. Zhang, D.Y. Gu, Q. Zhang, X.Y. Huo, C.J. Tang and J.F. Chen
Published data regarding the association between the cytosolic serine hydroxymethyltransferase (SHMT1) C1420T (Leu474Phe) polymorphism and solid tumor risk have shown inconclusive results. To derive a more precise estimation of the relationship, we performed a meta-analysis of 23 published studies that included 14,409 cancer cases and 16,996 controls. A c.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.25.12
- DOI:
- 10.4238/2015.May.25.12
Autophagy in drug resistance of the multiple myeloma cell line RPMI8226 to doxorubicin
Authors: Y.-Z. Pan, X. Wang, H. Bai, C.-B. Wang, Q. Zhang and R. Xi
We investigated the effect of autophagy on drug resistance of multiple myeloma (MM) to doxorubicin (DOX). A DOX-resistant MM cell line (RPMI8226/DOX) was developed by progressively increasing the DOX concentration gradient. The drug resistance index was determined using the MTT method. Transmission electron microscopy, anti-light chain 3-fluorescein isoth.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.25.14
- DOI:
- 10.4238/2015.May.25.14
Ara-C and anti-CD47 antibody combination therapy eliminates acute monocytic leukemia THP-1 cells in vivo and in vitro
Authors: Y. Wang, C. Yin, L. Feng, C. Wang and G. Sheng
Leukemia stem cells (LSCs) are regarded as the origin of leukemia and its recurrence. Side population (SP) cells possess some intrinsic stem cell properties and contain numerous LSCs. In this study, we examined the prognostic significance of cluster differentiation 47 (CD47) and identified the appropriate target for eliminating LSCs. We determined the per.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.25.15
- DOI:
- 10.4238/2015.May.25.15
In vitro study of the cytotoxic and genotoxic effects of indomethacin-loaded Eudragit�® L 100 nanocapsules
Authors: J.G. Froder, D. Dupeyr�³n, J.C.T. Carvalho and E.L. Maistro
Indomethacin is a non-steroidal anti-inflammatory agent included in one of the most commonly used drug classes worldwide. The use of this drug results in certain side effects, including gastrointestinal complications. Therefore, there exists a need to develop better methods for the delivery of such drugs into the body, such as those employing nanoparticle.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038727
- DOI:
- 10.4238/gmr.15038727
EPSPS variability, gene expression, and enzymatic activity in glyphosate-resistant biotypes of Digitaria insularis
Authors: E. Galeano, A.A.M. Barroso, T.S. Vasconcelos, A. L�³pez-Rubio, A.J.P. Albrecht, R. Victoria Filho and H. Carrer
Weed resistance to herbicides is a natural phenomenon that exerts selection on individuals in a population. In Brazil, glyphosate resistance was recently detected in Digitaria insularis. The objective of this study was to elucidate mechanisms of weed resistance in this plant, including genetic variability, allelism, amino acid substitutions, gene expressi.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038730
- DOI:
- 10.4238/gmr.15038730
Proteome analysis of the liver in the Chinese fire-bellied newt Cynops orientalis
Authors: X.Y. Zang, J.L. Guo1, X.F. Geng, P.F. Li, J.Y. Sun, Q.W. Wang and C.S. Xu
The Chinese fire-bellied newt, Cynops orientalis, belonging to Amphibia, Caudata, Salamandridae is a species endemic to China. The liver, which is an important digestive gland and the largest amphibian organ, has various functions, including detoxification, glycogen storage, protein synthesis, and hormone production. However, the newt liver has rarely bee.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15037993
- DOI:
- 10.4238/gmr.15037993
Porcine MAP3K5 analysis: molecular cloning, characterization, tissue expression pattern, and copy number variations associated with residual feed intake
Authors: L. Pu, L.C. Zhang, J.S. Zhang, X. Song, L.G. Wang, J. Liang, Y.B. Zhang, X. Liu, H. Yan, T. Zhang, J.W. Yue, N. Li, Q.Q. Wu and L.X. Wang
Mitogen-activated protein kinase kinase kinase 5 (MAP3K5) is essential for apoptosis, proliferation, differentiation, and immune responses, and is a candidate marker for residual feed intake (RFI) in pig. We cloned the full-length cDNA sequence of porcine MAP3K5 by rapid-amplification of cDNA ends. The 5451-bp gene contains a 5'-untranslated region (UTR) .. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15037998
- DOI:
- 10.4238/gmr.15037998