Medical Genetics
Effects of simulated weightlessness on cellular morphology and biological characteristics of cell lines SGC-7901 and HFE-145
Authors: M. Zhu, X.W. Jin, B.Y. Wu, J.L. Nie and Y.H. Li
We investigated the effects of simulated weightlessness on cellular morphology, proliferation, cell cycle, and apoptosis of the human gastric carcinoma cell line SGC-7901 and the human gastric normal cell line HFE-145. A rotating clinostat was used to simulate weightlessness. The Image-Pro4.5 image analysis system was used for.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.August.7.20
- DOI:
- 10.4238/2014.August.7.20
Relationship between a lipoprotein lipase gene polymorphism in placental tissue and insulin resistance in patients with gestational diabetes mellitus
Authors: D.D. Li, D.Y. Su, L. Xue, W. Gao and W.Y. Pang
The aim of this study was to investigate the relationship between a lipoprotein lipase (LPL) gene polymorphism in placental tissue and insulin resistance (IR) in patients with gestational diabetes mellitus. Using polymerase chain reaction-restriction enzyme fragment length polymorphism (PCR-RFLP) analysis, the LPL HindIII RFLP was examined in the placenta.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.14.1
- DOI:
- 10.4238/2015.July.14.1
Protective effect and mechanism of probucol in the treatment of spinal cord injury
Authors: W.B. Zhu, Y.H. Wang, G.F. Sun and J.H. Wu
To investigate the effects of probucol on the treatment of spinal cord injury in rat, 80 rats were randomly divided into two groups of 40: a group treated with probucol and a control group. Allen’s method was used to establish a rat model of spinal cord injury. After establishment, probucol (500 mg·kg-1·day-1) was intraperitoneally inj.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.17.11
- DOI:
- 10.4238/2015.July.17.11
Isolation and characterization of cancer stem cells from medulloblastoma
Authors: J. Liu, N. Chi, J.Y. Zhang, W. Zhu, Y.S. Bian and H.G. Chen
Brain cancer stem cells are a subset of tumor cells present in several types of brain tumor that evade treatment regimens and are responsible for tumor recurrence. Recent reports on several tumors have suggested that Hoechst 33342 dye exclusion is a powerful technique for isolating cancer stem cell-like side population (SP) cells. In the present study, we.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.13.15
- DOI:
- http://dx.doi.org/10.4238/2015.April.13.15
Changes to the migratory inhibitory factor, IL-17, and IL-10 levels in serum from chronic hepatitis B patients and clinical significance following Baraclude�® treatment
Authors: X.-H. Yu, J.-C. Zhang, X.-Y. Li and T. Chen
This study aimed to determine the relationship between changes in the serum levels of macrophage migratory inhibitory factor (MIF), interleukin (IL) 17, and IL-10 during chronic hepatitis B treatment via Baraclude® (Bristol-Meyers Squibb). Thirty-six patients with chronic hepatitis B and 24 healthy individuals were selected as the experimental and con.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.13.16
- DOI:
- http://dx.doi.org/10.4238/2015.April.13.16
Reduced cortisol in the absence of bacterial infection in patients with hepatitis B virus cirrhosis
Authors: J. Zhang, H.-W. Yu, J. Li, Y.-K. Zhu, K.-F. Wang, L. Jia and Q.-H. Meng
In liver cirrhosis with bacterial infection, hepatoadrenal syndrome has been described recently as a progressive impairment in the adrenocortical reserve, with deficient production or action of glucocorticoids resulting in adrenal insufficiency. The aim of this study was to explore the characteristics of cortisol in hepatitis B virus (HBV) cirrhosis patie.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.17.3
- DOI:
- 10.4238/2015.July.17.3
Mutation analysis of PVRL1 in patients with non-syndromic cleft of the lip and/or palate in Guangdong
Authors: S.Y. Shu, M.J. Zhang, H.Q. Cheng, S.J. Tang, W.L. Chen, S.R. Wu,Y. Lin and Q.S. Chen
Non-syndromic cleft of the lip and/or palate (NSCLP) is a very common birth defect; the poliovirus receptor-like 1 gene (PVRL1) has been identified as a genetic risk factor for NSCLP in patients from Norway, the Philippines, and South America. Given the considerable variation in allele frequencies across these geographical regions, this study explored the.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.15.3
- DOI:
- http://dx.doi.org/10.4238/2015.April.15.3
Discovery of clubroot-resistant genes in Brassica napus by transcriptome sequencing
Authors: S.W. Chen T. Liu, Y. Gao, C. Zhang, S.D. Peng, M.B. Bai, S.J. Li, L. Xu, X.Y. Zhou and L.B. Lin
Clubroot significantly affects plants of the Brassicaceae family and is one of the main diseases causing serious losses in B. napus yield. Few studies have investigated the clubroot-resistance mechanism in B. napus. Identification of clubroot-resistant genes may be used in clubroot-resistant breeding, as well as to elucidate the molecular mechanism behind.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038243
- DOI:
- 10.4238/gmr.15038243
Study of the influence of ethanol on basic fibroblast growth factor structure
Authors: G.H. Brancaleoni, M.R. Lourenzoni and L. Degr�¨ve
The growth of cells is controlled by stimulatory or inhibitory factors. More than twenty different families of polypeptide growth factors have been structurally and functionally characterized. Basic fibroblast growth factor (bFGF) of the fibroblast growth factor family was characterized in 1974 as having proliferative activity.. Read More»
- Genet. Mol. Res. 5(2):
Rehmannia glutinosa oligosaccharide induces differentiation of bone marrow mesenchymal stem cells into cardiomyocyte-like cells
Authors: X.H. Wang, H.W. Du, X.H. Guo, S.W. Wang, R.B. Zhou, Y. Li, Z.B. Li, Y.S. Zhao and Q.L. Zhu
The aim of this study was to observe the effect of Rehmannia glutinosa oligosaccharide (RGO) on differentiation of bone marrow mesenchymal stem cells (MSCs) into cardiomyocyte-like cells . Rat MSCs were isolated, treated, and grouped as follows: RGO treatment group, 5-azacytidine (5-aza) treatment group, RGO + 5-aza treatment .. Read More»
- Genet. Mol. Res. 15(4):
- gmr15047795
- DOI:
- 10.4238/gmr15047795