Medical Genetics

Accurate monitoring of promoter gene methylation with high-resolution melting polymerase chain reaction using the ABCB1 gene as a model

Authors: A.L. Mencalha, E.F. Rodrigues, E. Abdelhay and T.S. Fernandez

Multidrug resistance is the major cause of cancer chemotherapy failure. This phenotype is mainly due to the overexpression of the human ABCB1 gene. Several studies have shown that the transcriptional regulation of this gene is complex. Yet, the impact of this transcriptional regulation has not been well studied in a clinical setting. The acquired expressi.. Read More»

Genet. Mol. Res. 12(1):

2013

DOI:

10.4238/2013

Scar trek: follicular frontiers in skin replacement therapy

Authors: Pereira CT, Herndon DN, Perez-Polo JR, Burke AS and Jeschke MG

Genet. Mol. Res. 6(1):

Genomic identification, phylogeny, and expression analysis of MLO genes involved in susceptibility to powdery mildew in Fragaria vesca

Authors: L.X. Miao, M. Jiang, Y.C. Zhang, X.F. Yang, H.Q. Zhang, Z.F. Zhang, Y.Z. Wang and G.H. Jiang

The MLO (powdery mildew locus O) gene family is important in resistance to powdery mildew (PM). In this study, all of the members of the MLO family were identified and analyzed in the strawberry (Fragaria vesca) genome. The strawberry contains at least 20 members of the MLO family, and the protein sequence contained between 171 and 1485 amino acids, with .. Read More»

Genet. Mol. Res. 15(3):

gmr.15038400

DOI:

10.4238/gmr.15038400

Expected coalescence times and segregating sites in a model of glacial cycles

Authors: F.F. Jesus, J.F. Wilkins, V.N. Solferini and J. Wakeley

The climatic fluctuations of the Quaternary have influenced the distribution of numerous plant and animal species. Several species suffer population reduction and fragmentation, becoming restricted to refugia during glacial periods and expanding again during interglacials. The reduction in population size may reduce the effect.. Read More»

Genet. Mol. Res. 5(3):

Association between G-217A polymorphism in the AGT gene and essential hypertension: a meta-analysis

Authors: R. Yao, Y.Y. Du, Y.Z. Zhang, Q.H. Chen, L.S. Zhao and L. Li

Numerous studies have evaluated the association between the angiotensinogen ( AGT ) G-217A gene polymorphism and essential hypertension risk. However, the results have been inconsistent. We examined whether the AGT G-217A gene polymorphism confers essential hypertension risk by conducting a meta-analysis. We conducted a literature sea.. Read More»

Genet. Mol. Res. 14(2):

2015.May.25.4

DOI:

10.4238/2015.May.25.4

Effects of forkhead box C2 on carcinogenesis and lymphatic metastasis in endometrial carcinoma

Authors: Y.Y. Fan, W.G. Deng, Y.N. Liu, Y.Y. Li, S.L. Deng and Y. Fu

We investigated the distribution of endometrial lymphatic vessels and expression of forkhead box C2 (FOXC2) in normal endometrium during menstrual cycle and in endometrial adenocarcinoma. Full-thickness uterine samples and endometrial adenocarcinoma samples were collected for immunohistochemical analysis using D2-40 and FOXC2 mouse monoclonal antibodies. .. Read More»

Genet. Mol. Res. 14(2):

2015.May.25.5

DOI:

10.4238/2015.May.25.5

Characteristics of cathelicidin-Bg, a novel gene expressed in the ear-side gland of Bufo gargarizans

Authors: F. Gao, W.F. Xu, L.P. Tang, M.M. Wang, X.J. Wang and Y.C. Qian

The traditional Chinese medicine Chan Su (toad venom) comprises dried secretions of the ear-side gland of Bufo gargarizans. Chan Su is known for its small molecular components, which include telocinobufagin, marinobufagin, and bufalin, while in other amphibians, studies mainly focus on peptide components. Until recently, no genes expressed in the ear-side.. Read More»

Genet. Mol. Res. 15(3):

gmr.15038481

DOI:

10.4238/gmr.15038481

Associations between TNF-�± polymorphisms and susceptibility to rheumatoid arthritis and vitiligo: a meta-analysis

Authors: Y.H. Lee and S.C. Bae

We investigated whether the tumor necrosis factor-a (TNF-α) promoter -238 A/G and -308 A/G polymorphisms are associated with rheumatoid arthritis (RA) and vitiligo susceptibility. MEDLINE and EMBASE databases and a manual search were used to identify articles in which TNF-α polymorphisms were determined in RA or vitiligo patients and controls... Read More»

Genet. Mol. Res. 14(2):

2015.May.25.6

DOI:

10.4238/2015.May.25.6

Effect of hydroxy safflower yellow A on myocardial apoptosis after acute myocardial infarction in rats

Authors: M.X. Zhou, J.H. Fu, Q. Zhang and J.Q. Wang

This study aimed to investigate the effect of hydroxy safflower yellow A (HSYA) on myocardial apoptosis after acute myocardial infarction (AMI) in rats. We randomly divided 170 male Wistar rats into 6 groups (N = 23): normal control, sham, control, SY (90 mg/kg), HSYA high-dose (HSYA-H, 40 mg/kg), and HSYA low-dose groups (HSYA-L, 20 mg/kg). Myocardial is.. Read More»

Genet. Mol. Res. 14(2):

http://dx.doi.org/2015.April.10.24

DOI:

http://dx.doi.org/10.4238/2015.April.10.24

Expression differences in TEL-AML1 fusion gene in leukemia glucocorticoid-sensitive and -resistant cell lines

Authors: X.W. Wang and Y.H. Xu

We investigated the expression differences of the TEL-AML1 fusion gene in a leukemia glucocorticoid (GC)-sensitive cell line (CEM) and a GC-resistant cell line (Jurkat). Changes in TEL-AML1 expression before and after GC exposure were analyzed. Expression of GC-sensitive and GC-resistant leukemia cells following initial diagnosis and during treatment was .. Read More»

Genet. Mol. Res. 14(3):

2015.July.14.14

DOI:

10.4238/2015.July.14.14