Medical Genetics
Cross-leg repair of large soft-tissue defects in distal sites of the feet by distally based neuro-fasciocutaneous flaps with perforating vessels
Authors: Z.Q. Wang, Y.L. Cao, Y.F. Huang, D.Q. Liu and X.F. Li
The objective of this study was to introduce a method for repairing large soft-tissue defects on the foot. Distally based neuro-fasciocutaneous flaps with perforating vessels were designed along the saphenous and sural neurovascular axes. The cutaneous perforating branches of the major arteries of the lower extremities were us.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.July.25.1
- DOI:
- 10.4238/2014.July.25.1
Identification of critical TF-miRNA-mRNA regulation loops for colorectal cancer metastasis
Authors: C. Wang D.Z. Hu and J.Z. Liu
To explore the potential cause of colorectal cancer metastasis, gene expression profiles, GSE21510, and miRNA expression profiles, GSE48074, were downloaded from the Gene Expression Omnibus database. Differentially expressed genes in metastatic colorectal and non metastatic colorectal cancer compared with the normal samples were identified via the limma p.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.22.19
- DOI:
- 10.4238/2015.May.22.19
Anastomosis groups and molecular variation in Pseudocercospora griseola
Authors: K.J. Damasceno-Silva, E.A. Souza, C.N.S. Freire and F.H. Ishikawa
The fungus Pseudocercospora griseola is the causal agent of angular leaf spot, a common bean (Phaseolus vulgaris L.) disease. The successful development of angular leaf spot-resistant cultivars depends on understanding the levels of variability in pathogen populations. P. griseola shows great pathogenic and genetic variation using inoculation on different.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.3.19
- DOI:
- 10.4238/2015.July.3.19
Ebp1 protein expression in cervical cancer tissue and its significance
Authors: L. Liu, D.Y. Xu, S.S. Yang and X.D. Li
The objectives of this study were to observe the changes in expression of ErbB-3 binding protein (Ebp1) in cervical cancer and to investigate their clinic significance. We detected the expression level of Ebp1 in cancerous and adjacent tissues from 56 patients with cervical cancer. We identified 21 Ebp1 positive samples (37.5%) from among the 56 cervical .. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.22.20
- DOI:
- 10.4238/2015.May.22.20
Correlation of CD4+ CD25+ Foxp3+ Treg with the recovery of joint function after total knee replacement in rats with osteoarthritis
Authors: S.-Y. Guo*, Y.-J. Ding, L. Li, T. Zhang, Z.-Z. Zhang and E.-S. Zhang
In this study, we observed changes in CD4+ CD25+ Foxp3+ Treg expression in rats with osteoarthritis (OA) to explore the role that CD4+ CD25+ Foxp3+ Treg plays in the decline in the condition of OA rats. Thirty rats were randomly divided into 2 groups equally and OA was induced in rats in the model group by injection of papain and l-cysteine into the right.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.3.4
- DOI:
- 10.4238/2015.July.3.4
Lack of clinical significance of the ImmuKnowTM-Cylex assay for the detection of cellular immune function in patients with renal cell carcinoma
Authors: K. Zheng, J.P. Zhang, J.M. Tan, W.Z. Wu, S.L. Yang and D.D. Ke
This study aimed to explore the clinical value of the CD4+ T cell ATP levels in patients with renal cell carcinoma through the application of the ImmuKnowTM-Cylex® assay. We recruited 104 patients with renal cancer who had undergone surgery at Fuzhou General Hospital from March 2009 to June 2012, and were subsequently treated by dendritic cell and cyt.. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.28.6
- DOI:
- http://dx.doi.org/10.4238/2015.September.28.6
Allele frequencies of combined DNA index system (CODIS) and non-CODIS short tandem repeat loci in Goi�¡s, Central Brazil
Authors: R.G. Rodovalho, G.S. Santos, L.M. Cavalcanti, B.F.S.M. Moura, E.L. Rodrigues, P.R. Lima, M.A.D. Gigonzac and T.C. Vieira
In studies of human identification, obtaining a high standard of outcomes and satisfactory conclusions are directly related to the use of highly polymorphic molecular markers. In addition to the combined DNA index system (CODIS) group, it is also important to implement non-CODIS markers into the analysis, as they increase the power of discrimination. Duri.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.3.6
- DOI:
- 10.4238/2015.July.3.6
Effects of isoflurane preconditioning in the delayed phase on myocardial tumor necrosis factor alpha levels and caspase-3 protein expression in a rabbit model of ischemia-reperfusion injury
Authors: K. Ran, D.Q. Zou, Y.Y. Xiao, Y.T. Chang, K.M. Duan , Y.W. Ou and Z.J. Li
This study aimed to investigate the protective effects and the mechanisms underlying these effects of isoflurane preconditioning in the delayed phase of myocardial ischemia-reperfusion injury. We randomly divided 30 healthy male New Zealand white rabbits into three groups with 10 rabbits in each group as follows: sham operation group (C group), ischemia-r.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.3.1
- DOI:
- 10.4238/2015.July.3.1
Serum level of endothelial cell-specific molecule-1 and prognosis of colorectal cancer.
Authors: H. Jiang, X.G. Fu and Y.T. Chen
We evaluated the clinical significance and explored the prognostic value of serum endothelial cell-specific molecule-1 (ESM-1) expression in colorectal cancer (CRC) in a Chinese population. Serum samples were obtained from 89 CRC patients undergoing surgical treatment and 90 healthy volunteers (control group). ESM-1 levels in serum samples from CRC patien.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.25.3
- DOI:
- 10.4238/2015.May.25.3
Molecular identification of Amazonian stingless bees using polymerase chain reaction single-strand conformation polymorphism
Authors: M.T. Souza and G.A. Carvalho-Zilse
In countries containing a mega diversity of wildlife, such as Brazil, identifying and characterizing biological diversity is a continuous process for the scientific community, even in face of technological and scientific advances. This activity demands initiatives for the taxonomic identification of highly diverse groups, such.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.July.25.4
- DOI:
- 10.4238/2014.July.25.4