Medical Genetics
Regulatory effect of iron regulatory protein-2 on iron metabolism in lung cancer
Authors: Z. Cheng, L.L. Dai, Y.N. Song, Y. Kang, J.M. Si, J. Xia and Y.F. Liu
Iron metabolism plays an important role in the pathogenesis of lung cancer. This study aimed to investigate the effect of gene silencing of iron regulatory protein-2 (IRP2) on mRNA and protein expression of transferrin (Tf), transferrin receptor (TfR), and ferritin (Fn) in A549 lung cancer cells. A549 cells were cultured and d.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.July.25.5
- DOI:
- 10.4238/2014.July.25.5
Treatment of seawater immersion-complicated open-knee joint fracture
Authors: J.G. Ai, F. Zhao, Z.M. Gao, W. Dai, L. Zhang, H.B. Chen and J.G. Zhou
The current study aimed to select suitable remedies for seawater immersion-complicated open-knee joint fracture by exploring the effects of different treatment methods. Forty adult rabbits weighing 2.20 ± 0.25 kg were divided equally into internal fracture fixation group (A), seawater-immersed group with primary interna.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.July.25.6
- DOI:
- 10.4238/2014.July.25.6
Prostate stem cell antigen rs2294008 (C>T) polymorphism and bladder cancer risk: a meta-analysis based on cases and controls
Authors: Y. Zhao, Z.L. Gui, S. Liao, F. Gao, Y.Z. Ge and R.P. Jia
Several published articles have evaluated the association between the prostate stem cell antigen (PSCA) rs2294008 (C>T) polymorphism and bladder cancer risk, but the results remain inconclusive. In order to derive a more precise estimation of the association, we performed a meta-analysis of four case-control studies that in.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.July.25.7
- DOI:
- 10.4238/2014.July.25.7
Genetic polymorphism in sex hormone metabolism and prostate cancer risk
Authors: E. Ersekerci, M. Sofikerim, S. Taheri, A. Demirtas and F. Halis
We compared single-nucleotide polymorphisms for point mutations in cytochrome P450 genes, including cytochrome P450c17α (CYP17), cytochrome P450 aromatase (CYP19), steroid-5-a-reductase (SRD5A2), and prostate-specific antigen (PSA) involved in androgen and estrogen production. Between January 2008 and January 2010, 90 patients were enrolled in the s.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.3.8
- DOI:
- 10.4238/2015.July.3.8
Association between EGF and VEGF functional polymorphisms and sporadic colorectal cancer in the Malaysian population
Authors: T.P. Lau, A.C. Roslani, L.H. Lian, P.C. Lee, I. Hilmi, K.L. Goh and K.H. Chua
Growth factors are polypeptides that are critical for the initiation, progression, and metastasis of cancer. Most tumor cells are capable of synthesizing particular growth factors leading to constitutive pathway activation in these cells through autocrine signaling. Epidermal growth factor (EGF) is a potent mitogenic peptide t.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.July.25.9
- DOI:
- 10.4238/2014.July.25.9
Proton pump inhibitor use and risk of spontaneous bacterial peritonitis in cirrhotic patients: a systematic review and meta-analysis
Authors: H.B. Xu, H.D. Wang, C.H. Li, S. Ye, M.S. Dong, Q.J. Xia, A.Q. Zhang, K. Pan, X.L. Ge and J.H. Dong
We used a meta-analysis approach to investigate the association between proton pump inhibitor (PPI) use and risk of spontaneous bacterial peritonitis (SBP) in cirrhotic patients. We searched Ovid Medline, Embase, and the Cochrane Library to identify eligible studies. We included studies that compared cirrhotic patients who did or did not use PPIs. The pri.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.3.25
- DOI:
- 10.4238/2015.July.3.25
Comparison of methods for estimates of molecular genetic diversity in genus Croton: influence of coefficients, clustering strategies and data projection
Authors: M.M. Scaldaferri, J.S. Freitas, J.G.P. Vieira, Z.S. Gon�§alves, A.M. Souza and C.B.M. Cerqueira-Silva
We investigated 10 similarity (and disimilarity) coefficients in a set of 40 wild genotypes of Croton linearifolius subjected to analyses using hierarchical grouping methods, grouping methods by optimization and data projection in two-dimensional space. Genotypes were characterized by analyzing DNA polymorphism with t.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.July.25.11
- DOI:
- 10.4238/2014.July.25.11
Key pathways involved in prostate cancer based on gene set enrichment analysis and meta analysis
Authors: Q.Y. Ning, J.Z. Wu, N. Zang, J. Liang, Y.L. Hu and Z.N. Mo
Prostate cancer is one of the most common male malignant neoplasms; however, its causes are not completely understood. A few recent studies have used gene expression profiling of prostate cancer to identify differentially expressed genes and possible relevant pathways. However, few studies have examined the genetic mechanics o.. Read More»
- Genet. Mol. Res. 10(4):
- 2011.December.14.10
- DOI:
- 10.4238/2011.December.14.10
Implications of microRNA-197 downregulated expression in esophageal cancer with poor prognosis
Authors: T.-Y. Wang, S.-G. Liu, B.-S. Zhao, B. Qi, X.-G. Qin and W.-J. Yao
The aim of this study was to investigate the significance of the microRNA miR-197 expression level in relation to clinicopathological factors and prognoses of esophageal cancer (EC). MicroRNA was extracted using the Taqman® MicroRNA Assay from 46 EC patients at the same tumor node metastasis (TNM) stage, but with different.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.July.25.12
- DOI:
- 10.4238/2014.July.25.12
A potential protective role for thiamine in glucose-driven oxidative stress
Authors: B. Palabiyik, F. Jafari Ghods and E. Onay Ucar
The relationship between glucose repression and the oxidative stress response was investigated in Schizosaccharomyces pombe wild type cells (972h-) and glucose repression resistant mutant type cells (ird11). We aimed to reveal the mechanism of simultaneous resistance to glucose repression and oxidati.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.July.25.13
- DOI:
- 10.4238/2014.July.25.13