Medical Genetics
Vascular endothelial growth factor gene polymorphisms and colorectal cancer risk: a meta-analysis
Authors: L.P. Zhou, H. Luan, X.H. Dong, G.J. Jin, D.L. Man and H. Shang
Vascular endothelial growth factor (VEGF) is an endothelial cell-specific mitogen involved in a number of pathologic processes, including angiogenesis, tumor growth and metastasis. Polymorphisms of the VEGF gene have been associated with susceptibility to colorectal cancer (CRC). However, the specific association still remains.. Read More»
- Genet. Mol. Res. 10(4):
- 2011.October.31.13
- DOI:
- 10.4238/2011.October.31.13
Influence of glutathione S-transferase polymorphisms on type-2 diabetes mellitus risk
Authors: M.A. Amer, M.H. Ghattas, D.M. Abo-ElMatty and S.H. Abou-El-Ela
Glutathione S-transferase (GST) protects cells against oxidative stress. We evaluated the effect of genetic polymorphisms of the GST gene family on the risk of developing type-2 diabetes mellitus and on glycemic control. We also investigated the effects of smoking combined with these polymorphisms on type-2 diabetes mellitus r.. Read More»
- Genet. Mol. Res. 10(4):
- 2011.October.31.14
- DOI:
- 10.4238/2011.October.31.14
Phenotypic correlations between ovum pick-up in vitro production traits and pregnancy rates in Zebu cows
Authors: W.H.O. Vega, C.R. Quirino, R.V. Serapi�£o, C.S. Oliveira and A. Pacheco
The growth of the Gyr breed in Brazil in terms of genetic gain for milk, along with conditions for market, has led to the use of ovum pick-up in vitro production (OPU-IVP) as a leader in biotechnology for the multiplication of genetic material. The aim of this study was to investigate phenotypic correlations between OPU-IVP-linked characteristics and preg.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.3.9
- DOI:
- 10.4238/2015.July.3.9
Investigation of the value of miR-21 in the diagnosis of early stage HCC and its prognosis: a meta-analysis
Authors: S.R. Yan, Z.J. Liu, S. Yu and Y.X. Bao
The diagnostic and prognostic value of miR-21 has been examined for hepatocellular carcinoma (HCC), with inconsistent results. Present meta-analysis summarized the diagnostic accuracy and the predictive role for survival of miR-21 in patients with HCC. All eligible studies were searched using PubMed, EMBASE, and Chinese National Knowledge Infrastructure (.. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.28.9
- DOI:
- http://dx.doi.org/10.4238/2015.September.28.9
Elimination of breast tumor-associated chondroitin sulfate promotes metastasis
Authors: R.D. Prinz, C.M. Willis, A. Viloria-Petit and M. Kl�¼ppel
Breast cancer is one of the leading causes of cancer-related deaths amongst women in the USA. The tumor microenvironment has been suggested to be an attractive therapeutic target for treatment of cancers. The glycosaminoglycan chondroitin sulfate, as part of the cellular microenvironment, consists of long linear chains of repe.. Read More»
- Genet. Mol. Res. 10(4):
- 2011.December.8.9
- DOI:
- 10.4238/2011.December.8.9
Correlation between the BRAF V600E mutation status and the clinicopathologic features of papillary thyroid carcinoma
Authors: C.L. Shi, Y. Sun, C. Ding, Y.C. Lv and H.D. Qin
This study sought to investigate the correlations of V-raf murine sarcoma viral oncogene homolog B1 (BRAF) gene mutations with the clinicopathologic features of papillary thyroid carcinoma and central lymph node metastasis. We retrospectively analyzed the 2-year medical records of patients who underwent surgery for papillary thyroid carcinoma. After scree.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.3.13
- DOI:
- 10.4238/2015.July.3.13
Genomic structure, polymorphism and expression analysis of growth hormone-releasing hormone and pituitary adenylate cyclase activating polypeptide genes in the half-smooth tongue sole (Cynoglossus semilaevis)
Authors: Q. Ma, S.F. Liu, Z.M. Zhuang, L. Lin, Z.Z. Sun, C.L. Liu, Y.Q. Su and Q.S. Tang
Growth hormone-releasing hormone (GHRH) and pituitary adenylate cyclase activating polypeptide (PACAP) regulate development and somatic growth in teleosts; they may be associated with sexual growth dimorphism in the half-smooth tongue sole (Cynoglossus semilaevis). We found that the full-length GHRH and PACAP gene sequences ob.. Read More»
- Genet. Mol. Res. 10(4):
- 2011.December.12.1
- DOI:
- 10.4238/2011.December.12.1
Genetic variability of genes involved in DNA repair influence treatment outcome in osteosarcoma
Authors: M.J. Wang, Y. Zhu, X.J. Guo and Z.Z. Tian
We conducted a perspective study to investigate the role of ERCC1 (rs11615), ERCC2 (rs13181 and rs1799793), ERCC4 (rs1800067), and ERCC5 (rs17655) in NER pathway in the prognosis of osteosarcoma patients. In total, 146 osteosarcoma patients were recruited between 2008 and 2013. ERCC1 rs11615, ERCC2 rs13181 and rs1799793, ERCC4 rs1800067, and ERCC5 rs17655.. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.28.17
- DOI:
- http://dx.doi.org/10.4238/2015.September.28.17
Identification of critical TF-miRNA-mRNA regulation loops for colorectal cancer metastasis.
Authors: C. Wang, D.Z. Hu and J.Z. Liu
To explore the potential cause of colorectal cancer metastasis, gene expression profiles, GSE21510, and miRNA expression profiles, GSE48074, were downloaded from the Gene Expression Omnibus database. Differentially expressed genes in metastatic colorectal and non metastatic colorectal cancer compared with the normal samples were identified via the limma p.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.22.19
- DOI:
- 10.4238/2015.May.22.19
Meta-analysis of the association between the HNF1B rs4430796 (A>G) polymorphism and risk of prostate cancer based on case-control studies
Authors: Y. Zhao, J. Liang, J.G. Qi, N. Yang, G. Wu, Y.L. Lin, J.Y. Cao, Q. Wang and Q.C. Wang
Genome-wide studies have reported an association between the HNF1B rs4430796 (A>G) polymorphism and prostate cancer risk, but results have been inconsistent and recent meta-analyses have been inadequate. This study aimed to integrate previous results and explore the validity of this association. Electronic searches for all relevant publications through.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.3.18
- DOI:
- 10.4238/2015.July.3.18